Lysine-based surfactants as chemical permeation enhancers for dermal delivery of local anesthetics

Detalhes bibliográficos
Autor(a) principal: Teixeira, Raquel S.
Data de Publicação: 2014
Outros Autores: Cova, Tânia F.G.G., Silva, Sérgio M.C., Oliveira, Rita, Araújo, Maria J., Marques, Eduardo F., Pais, Alberto A.C.C., Veiga, Francisco J.B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10284/10670
Resumo: The aim of this study is to investigate the efficacy of new, biocompatible, lysine-based surfactants as chemical permeation enhancers for two different local anesthetics, tetracaine and ropivacaine hydrochloride, topically administered. Results show that this class of surfactants strongly influences permeation, especially in the case of the hydrophilic and ionized drug, ropivacaine hydrochloride, that is not easily administered through the stratum corneum. It is also seen that the selected permeation enhancers do not have significant deleterious effects on the skin structure. A cytotoxicity profile for each compound was established from cytotoxicity studies. Molecular dynamics simulation results provided a rationale for the experimental observations, introducing a mechanistic view of the action of the surfactants molecules upon lipid membranes.
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spelling Lysine-based surfactants as chemical permeation enhancers for dermal delivery of local anestheticsDermal drug deliveryChemical permeation enhancersCytotoxicityTetracaineRopivacaineMolecular dynamic simulationThe aim of this study is to investigate the efficacy of new, biocompatible, lysine-based surfactants as chemical permeation enhancers for two different local anesthetics, tetracaine and ropivacaine hydrochloride, topically administered. Results show that this class of surfactants strongly influences permeation, especially in the case of the hydrophilic and ionized drug, ropivacaine hydrochloride, that is not easily administered through the stratum corneum. It is also seen that the selected permeation enhancers do not have significant deleterious effects on the skin structure. A cytotoxicity profile for each compound was established from cytotoxicity studies. Molecular dynamics simulation results provided a rationale for the experimental observations, introducing a mechanistic view of the action of the surfactants molecules upon lipid membranes.ElsevierRepositório Institucional da Universidade Fernando PessoaTeixeira, Raquel S.Cova, Tânia F.G.G.Silva, Sérgio M.C.Oliveira, RitaAraújo, Maria J.Marques, Eduardo F.Pais, Alberto A.C.C.Veiga, Francisco J.B.2022-01-27T12:36:38Z2014-01-01T00:00:00Z2014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10284/10670eng0378-517310.1016/j.ijpharm.2014.08.002metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-06T02:09:56Zoai:bdigital.ufp.pt:10284/10670Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:47:26.106813Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Lysine-based surfactants as chemical permeation enhancers for dermal delivery of local anesthetics
title Lysine-based surfactants as chemical permeation enhancers for dermal delivery of local anesthetics
spellingShingle Lysine-based surfactants as chemical permeation enhancers for dermal delivery of local anesthetics
Teixeira, Raquel S.
Dermal drug delivery
Chemical permeation enhancers
Cytotoxicity
Tetracaine
Ropivacaine
Molecular dynamic simulation
title_short Lysine-based surfactants as chemical permeation enhancers for dermal delivery of local anesthetics
title_full Lysine-based surfactants as chemical permeation enhancers for dermal delivery of local anesthetics
title_fullStr Lysine-based surfactants as chemical permeation enhancers for dermal delivery of local anesthetics
title_full_unstemmed Lysine-based surfactants as chemical permeation enhancers for dermal delivery of local anesthetics
title_sort Lysine-based surfactants as chemical permeation enhancers for dermal delivery of local anesthetics
author Teixeira, Raquel S.
author_facet Teixeira, Raquel S.
Cova, Tânia F.G.G.
Silva, Sérgio M.C.
Oliveira, Rita
Araújo, Maria J.
Marques, Eduardo F.
Pais, Alberto A.C.C.
Veiga, Francisco J.B.
author_role author
author2 Cova, Tânia F.G.G.
Silva, Sérgio M.C.
Oliveira, Rita
Araújo, Maria J.
Marques, Eduardo F.
Pais, Alberto A.C.C.
Veiga, Francisco J.B.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Institucional da Universidade Fernando Pessoa
dc.contributor.author.fl_str_mv Teixeira, Raquel S.
Cova, Tânia F.G.G.
Silva, Sérgio M.C.
Oliveira, Rita
Araújo, Maria J.
Marques, Eduardo F.
Pais, Alberto A.C.C.
Veiga, Francisco J.B.
dc.subject.por.fl_str_mv Dermal drug delivery
Chemical permeation enhancers
Cytotoxicity
Tetracaine
Ropivacaine
Molecular dynamic simulation
topic Dermal drug delivery
Chemical permeation enhancers
Cytotoxicity
Tetracaine
Ropivacaine
Molecular dynamic simulation
description The aim of this study is to investigate the efficacy of new, biocompatible, lysine-based surfactants as chemical permeation enhancers for two different local anesthetics, tetracaine and ropivacaine hydrochloride, topically administered. Results show that this class of surfactants strongly influences permeation, especially in the case of the hydrophilic and ionized drug, ropivacaine hydrochloride, that is not easily administered through the stratum corneum. It is also seen that the selected permeation enhancers do not have significant deleterious effects on the skin structure. A cytotoxicity profile for each compound was established from cytotoxicity studies. Molecular dynamics simulation results provided a rationale for the experimental observations, introducing a mechanistic view of the action of the surfactants molecules upon lipid membranes.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01T00:00:00Z
2014-01-01T00:00:00Z
2022-01-27T12:36:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10284/10670
url http://hdl.handle.net/10284/10670
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0378-5173
10.1016/j.ijpharm.2014.08.002
dc.rights.driver.fl_str_mv metadata only access
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rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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