Serum iodine and bromine in chronic hemodialysis patients—an observational study in a cohort of portuguese patients
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/23077 |
Resumo: | Patients on chronic hemodialysis therapy are at high risk of disturbances in trace element status due to both the underlying disease and the hemodialysis process itself. Data on iodine and bromine levels in these patients are scarce. Using an ICP-MS analytical procedure, serum iodine and bromine levels were determined in a cohort (n = 57) of end-stage renal disease patients on chronic hemodialysis. The results were compared with those of a control group (n = 59). Results: Hemodialysis patients presented serum iodine levels within the normal range, slightly lower than in controls, but without reaching a statistically significant difference (67.6 ± 17.1 µg/L vs. 72.2 ± 14.8 µg/L; p = 0.1252). In contrast, serum bromine levels were much lower in patients (1086 ± 244 µg/L vs. 4137 ± 770 µg/L; p < 0.0001), at values only about 26% of the values observed in controls. Hemodialysis patients had normal serum iodine levels, but highly decreased serum bromine levels. The clinical significance of this finding requires further investigation, but it may be associated with sleep disturbances and fatigue that affect hemodialysis patients. |
id |
RCAP_d2019c1d54be000c0118f91d2220fc6c |
---|---|
oai_identifier_str |
oai:recipp.ipp.pt:10400.22/23077 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Serum iodine and bromine in chronic hemodialysis patients—an observational study in a cohort of portuguese patientsIodineBromineSerum levelsERSDHemodialysis patientsPatients on chronic hemodialysis therapy are at high risk of disturbances in trace element status due to both the underlying disease and the hemodialysis process itself. Data on iodine and bromine levels in these patients are scarce. Using an ICP-MS analytical procedure, serum iodine and bromine levels were determined in a cohort (n = 57) of end-stage renal disease patients on chronic hemodialysis. The results were compared with those of a control group (n = 59). Results: Hemodialysis patients presented serum iodine levels within the normal range, slightly lower than in controls, but without reaching a statistically significant difference (67.6 ± 17.1 µg/L vs. 72.2 ± 14.8 µg/L; p = 0.1252). In contrast, serum bromine levels were much lower in patients (1086 ± 244 µg/L vs. 4137 ± 770 µg/L; p < 0.0001), at values only about 26% of the values observed in controls. Hemodialysis patients had normal serum iodine levels, but highly decreased serum bromine levels. The clinical significance of this finding requires further investigation, but it may be associated with sleep disturbances and fatigue that affect hemodialysis patients.MDPIRepositório Científico do Instituto Politécnico do PortoNovakova, GerganaBonev, PresianDuro, MaryAzevedo, RuiCouto, CristinaPinto, EdgarAlmeida, Agostinho2023-06-05T15:44:16Z2023-03-062023-03-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/23077engNovakova, G., Bonev, P., Duro, M., Azevedo, R., Couto, C., Pinto, E., & Almeida, A. (2023). Serum Iodine and Bromine in Chronic Hemodialysis Patients—An Observational Study in a Cohort of Portuguese Patients. Toxics, 11(3), 247. https://doi.org/10.3390/toxics1103024710.3390/toxics110302472305-6304info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-06-07T01:46:55Zoai:recipp.ipp.pt:10400.22/23077Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:59:56.862571Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Serum iodine and bromine in chronic hemodialysis patients—an observational study in a cohort of portuguese patients |
title |
Serum iodine and bromine in chronic hemodialysis patients—an observational study in a cohort of portuguese patients |
spellingShingle |
Serum iodine and bromine in chronic hemodialysis patients—an observational study in a cohort of portuguese patients Novakova, Gergana Iodine Bromine Serum levels ERSD Hemodialysis patients |
title_short |
Serum iodine and bromine in chronic hemodialysis patients—an observational study in a cohort of portuguese patients |
title_full |
Serum iodine and bromine in chronic hemodialysis patients—an observational study in a cohort of portuguese patients |
title_fullStr |
Serum iodine and bromine in chronic hemodialysis patients—an observational study in a cohort of portuguese patients |
title_full_unstemmed |
Serum iodine and bromine in chronic hemodialysis patients—an observational study in a cohort of portuguese patients |
title_sort |
Serum iodine and bromine in chronic hemodialysis patients—an observational study in a cohort of portuguese patients |
author |
Novakova, Gergana |
author_facet |
Novakova, Gergana Bonev, Presian Duro, Mary Azevedo, Rui Couto, Cristina Pinto, Edgar Almeida, Agostinho |
author_role |
author |
author2 |
Bonev, Presian Duro, Mary Azevedo, Rui Couto, Cristina Pinto, Edgar Almeida, Agostinho |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Novakova, Gergana Bonev, Presian Duro, Mary Azevedo, Rui Couto, Cristina Pinto, Edgar Almeida, Agostinho |
dc.subject.por.fl_str_mv |
Iodine Bromine Serum levels ERSD Hemodialysis patients |
topic |
Iodine Bromine Serum levels ERSD Hemodialysis patients |
description |
Patients on chronic hemodialysis therapy are at high risk of disturbances in trace element status due to both the underlying disease and the hemodialysis process itself. Data on iodine and bromine levels in these patients are scarce. Using an ICP-MS analytical procedure, serum iodine and bromine levels were determined in a cohort (n = 57) of end-stage renal disease patients on chronic hemodialysis. The results were compared with those of a control group (n = 59). Results: Hemodialysis patients presented serum iodine levels within the normal range, slightly lower than in controls, but without reaching a statistically significant difference (67.6 ± 17.1 µg/L vs. 72.2 ± 14.8 µg/L; p = 0.1252). In contrast, serum bromine levels were much lower in patients (1086 ± 244 µg/L vs. 4137 ± 770 µg/L; p < 0.0001), at values only about 26% of the values observed in controls. Hemodialysis patients had normal serum iodine levels, but highly decreased serum bromine levels. The clinical significance of this finding requires further investigation, but it may be associated with sleep disturbances and fatigue that affect hemodialysis patients. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-06-05T15:44:16Z 2023-03-06 2023-03-06T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/23077 |
url |
http://hdl.handle.net/10400.22/23077 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Novakova, G., Bonev, P., Duro, M., Azevedo, R., Couto, C., Pinto, E., & Almeida, A. (2023). Serum Iodine and Bromine in Chronic Hemodialysis Patients—An Observational Study in a Cohort of Portuguese Patients. Toxics, 11(3), 247. https://doi.org/10.3390/toxics11030247 10.3390/toxics11030247 2305-6304 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799131668823408640 |