Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes

Detalhes bibliográficos
Autor(a) principal: Viveiros, Raquel
Data de Publicação: 2022
Outros Autores: Maia, Luísa B., Corvo, Marta C., Bonifácio, Vasco D. B., Heggie, William, Casimiro, Teresa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/145600
Resumo: Principal Investigator contract IF/00915/2014 (T.C.), and a doctoral grant , a partnership from FCT/MCTES and the pharmaceutical company HOVIONE (R.V.). L.B.M. would like to acknowledge for FCT/MCTES funding with reference CEECIND/03810/2017. The NMR spectrometers in LabNMR@Cenimat are part of the National NMR Facility, supported by FCT (ROTEIRO/0031/2013 - PINFRA/22161/2016 ), co-financed by FEDER through COMPETE 2020, POCI, and PORL and FCT through PIDDAC ( POCI-01-0145-FEDER-007688 ; UID/CTM/50025/2020-2023 ). The Associate Laboratory Research Unit for Green Chemistry - Clean Technologies and Processes - LAQV is financed by national funds from FCT/MCTES ( UIDB/QUI/50006/2020 ) and cofunded by the ERDF under the PT2020 Partnership Agreement ( POCI-01-0145-FEDER-007265 ). We also acknowledge Dr. Luz Fernandes, REQUIMTE analytical services, for GC analysis. Publisher Copyright: © 2022
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spelling Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processesArtificial enzymesCatalysisGreen chemistryMolecular recognitionMolecularly imprinted polymersTEMPOCatalysisChemistry(all)Process Chemistry and TechnologyPrincipal Investigator contract IF/00915/2014 (T.C.), and a doctoral grant , a partnership from FCT/MCTES and the pharmaceutical company HOVIONE (R.V.). L.B.M. would like to acknowledge for FCT/MCTES funding with reference CEECIND/03810/2017. The NMR spectrometers in LabNMR@Cenimat are part of the National NMR Facility, supported by FCT (ROTEIRO/0031/2013 - PINFRA/22161/2016 ), co-financed by FEDER through COMPETE 2020, POCI, and PORL and FCT through PIDDAC ( POCI-01-0145-FEDER-007688 ; UID/CTM/50025/2020-2023 ). The Associate Laboratory Research Unit for Green Chemistry - Clean Technologies and Processes - LAQV is financed by national funds from FCT/MCTES ( UIDB/QUI/50006/2020 ) and cofunded by the ERDF under the PT2020 Partnership Agreement ( POCI-01-0145-FEDER-007265 ). We also acknowledge Dr. Luz Fernandes, REQUIMTE analytical services, for GC analysis. Publisher Copyright: © 2022Catalysis in pharma manufacturing processes is typically homogeneous, expensive and with hard catalyst recovery/regeneration. Herein an enzyme-inspired dry-powder molecularly imprinted polymeric (MIP) system was designed for fast, selective oxidation of a cholesterol derivative and easy catalyst regeneration. The strategy involved the synthesis of a template-monomer (T:M) complex followed by the crosslinked polymerization in supercritical carbon dioxide (scCO2). A 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-MIP catalyst is obtained after the template cleavage from the matrix, and the oxidation of the N[sbnd]H groups turns available TEMPO moieties within the MIP. The oxidation of benzyl alcohol, 5α-cholestan-3β-ol and cholic acid was fast, in high yield and with selective oxidation capacity.LAQV@REQUIMTEDQ - Departamento de QuímicaDCM - Departamento de Ciência dos MateriaisCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)RUNViveiros, RaquelMaia, Luísa B.Corvo, Marta C.Bonifácio, Vasco D. B.Heggie, WilliamCasimiro, Teresa2022-11-17T22:13:18Z2022-122022-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://hdl.handle.net/10362/145600eng1566-7367PURE: 47408938https://doi.org/10.1016/j.catcom.2022.106537info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:26:08Zoai:run.unl.pt:10362/145600Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:52:10.195577Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes
title Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes
spellingShingle Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes
Viveiros, Raquel
Artificial enzymes
Catalysis
Green chemistry
Molecular recognition
Molecularly imprinted polymers
TEMPO
Catalysis
Chemistry(all)
Process Chemistry and Technology
title_short Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes
title_full Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes
title_fullStr Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes
title_full_unstemmed Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes
title_sort Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes
author Viveiros, Raquel
author_facet Viveiros, Raquel
Maia, Luísa B.
Corvo, Marta C.
Bonifácio, Vasco D. B.
Heggie, William
Casimiro, Teresa
author_role author
author2 Maia, Luísa B.
Corvo, Marta C.
Bonifácio, Vasco D. B.
Heggie, William
Casimiro, Teresa
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
DCM - Departamento de Ciência dos Materiais
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
RUN
dc.contributor.author.fl_str_mv Viveiros, Raquel
Maia, Luísa B.
Corvo, Marta C.
Bonifácio, Vasco D. B.
Heggie, William
Casimiro, Teresa
dc.subject.por.fl_str_mv Artificial enzymes
Catalysis
Green chemistry
Molecular recognition
Molecularly imprinted polymers
TEMPO
Catalysis
Chemistry(all)
Process Chemistry and Technology
topic Artificial enzymes
Catalysis
Green chemistry
Molecular recognition
Molecularly imprinted polymers
TEMPO
Catalysis
Chemistry(all)
Process Chemistry and Technology
description Principal Investigator contract IF/00915/2014 (T.C.), and a doctoral grant , a partnership from FCT/MCTES and the pharmaceutical company HOVIONE (R.V.). L.B.M. would like to acknowledge for FCT/MCTES funding with reference CEECIND/03810/2017. The NMR spectrometers in LabNMR@Cenimat are part of the National NMR Facility, supported by FCT (ROTEIRO/0031/2013 - PINFRA/22161/2016 ), co-financed by FEDER through COMPETE 2020, POCI, and PORL and FCT through PIDDAC ( POCI-01-0145-FEDER-007688 ; UID/CTM/50025/2020-2023 ). The Associate Laboratory Research Unit for Green Chemistry - Clean Technologies and Processes - LAQV is financed by national funds from FCT/MCTES ( UIDB/QUI/50006/2020 ) and cofunded by the ERDF under the PT2020 Partnership Agreement ( POCI-01-0145-FEDER-007265 ). We also acknowledge Dr. Luz Fernandes, REQUIMTE analytical services, for GC analysis. Publisher Copyright: © 2022
publishDate 2022
dc.date.none.fl_str_mv 2022-11-17T22:13:18Z
2022-12
2022-12-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/145600
url http://hdl.handle.net/10362/145600
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1566-7367
PURE: 47408938
https://doi.org/10.1016/j.catcom.2022.106537
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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