Highlights of the 2nd international symposium on tribbles and diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/12538 |
Resumo: | The Tribbles (TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2nd International Symposium on Tribbles and Diseases held on May 7-9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. (C) 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. |
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Highlights of the 2nd international symposium on tribbles and diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancerTribblesImmunologyMetabolismCell biologyKinase inhibitorTumorigenesisMetastasisTRIB1TRIB2TRIB3PseudokinaseInflammationAtomic structureProtein quality controlUbiqutinThe Tribbles (TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2nd International Symposium on Tribbles and Diseases held on May 7-9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. (C) 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.Agência financiadora / Número do subsídio National Key R&D Program of China (China) 2017YFA0205400 National Natural Science Foundation of China (China) 81530093 81773781 81874316 81503128 81400140 81400286 81703564 81603129 81472717 81673474 Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (China) 2016-12M-1-007 CAMS Central Public-interest Scientific Institution Basic Research Fund (China) 2017PT3104 CAMS Innovation Fund for Medical Sciences (China) 2016-I2M-3-008 201642M-1-008 201642M-1-007 201642M-1-011 201642M-1-010 BBSRC (UK) 1088 1097 NWCR (UK) 1088 1097 NSF (USA) IOS-1456023 NIH (USA) NIH R21 CA197317 Ministry of Education, Singapore (Singapore) MOE2014-T2-1-012 2012-T1-001-036 Health Research Council of New Zealand Rutherford Discovery Fellowship from the New Zealand government Fundacao para a Ciencia e a Tecnologia (FCT) UID/KM/04773/2013 Liga Portuguesa Contra o Cancro NUcleo Regional do Sul (LPCC/NRS, Portugal) FCT 2014 research grant (Portugal) SFRH/BPD/100434/2014 ProRegem grant (Portugal) PD/BD/114258/2016 European Marie Sklodowska Curie ITN Project TRAIN-TRIBBLES Research and Innovation Network (EU) 721532 British Heart Foundation (UK) PG/16/44/32146 Howat Foundation Ltd. (UK) Children with Cancer UK (UK) Bloodwise (UK) Friends of Paul O' Gorman (UK) grants of P-CREATE from Japan Agency for Medical Research and Development NIH (NIAID, USA) Alex' s Lemonade Stand Foundation (USA) Samuel Waxman Cancer Research Foundation (USA) French government (France) ANR-10-IBHU-005 ANR-11-LABX-0016-01 European Marie Sklodowska Curie ITN Project TRAIN-TRIBBLES Research and Innovation Network (UK) 721532 A* Star Institute (UK) University of Sheffield (UK) National Institutes of Health National Heart, Lung, and Blood Institute (USA) R01HL141745 National Institute of Health (USA) NS R01-035546 Spanish Ministry of Economy and Competitiveness (MINECO) (Spain) INNPACTO/IPT-2012-0614-010000 Fondo Europeo de desarrollo Regional (FEDER) (Spain) INNPACTO/IPT-2012-0614-010000 PerkinElmer Innovent Biologics Nantes Metropole (France) Region Pays de la Loire (France) Beijing Natural Science Foundation (China) 7162133ElsevierSapientiaCui, BingEyers, Patrick A.Dobens, Leonard L.Tan, Nguan SoonMace, Peter D.Link, WolfgangKiss-Toth, EndreKeeshan, KarenNakamura, TakuroPear, Warren S.Feseha, YoditJohnston, JessicaCarracedo, ArkatizScheideler, Marcelllyas, ZabranBauer, Robert C.Erusalimsky, Jorge D.Grzesik, DominikaSalamanca-Viloria, JuanLv, XiaoxiJin, YishiLi, KeVelasco, GuillermoShang, ShuangLizcano, Jose M.Zhang, XiaoweiZhou, JichaoYu, JiaojiaoHua, FangWang, FengLiu, ShanshanYu, JinmeiHu, Zhuowei2019-05-21T14:22:27Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/12538eng2211-383510.1016/j.apsb.2018.12.007info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:24:31Zoai:sapientia.ualg.pt:10400.1/12538Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:03:52.554530Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Highlights of the 2nd international symposium on tribbles and diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer |
title |
Highlights of the 2nd international symposium on tribbles and diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer |
spellingShingle |
Highlights of the 2nd international symposium on tribbles and diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer Cui, Bing Tribbles Immunology Metabolism Cell biology Kinase inhibitor Tumorigenesis Metastasis TRIB1 TRIB2 TRIB3 Pseudokinase Inflammation Atomic structure Protein quality control Ubiqutin |
title_short |
Highlights of the 2nd international symposium on tribbles and diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer |
title_full |
Highlights of the 2nd international symposium on tribbles and diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer |
title_fullStr |
Highlights of the 2nd international symposium on tribbles and diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer |
title_full_unstemmed |
Highlights of the 2nd international symposium on tribbles and diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer |
title_sort |
Highlights of the 2nd international symposium on tribbles and diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer |
author |
Cui, Bing |
author_facet |
Cui, Bing Eyers, Patrick A. Dobens, Leonard L. Tan, Nguan Soon Mace, Peter D. Link, Wolfgang Kiss-Toth, Endre Keeshan, Karen Nakamura, Takuro Pear, Warren S. Feseha, Yodit Johnston, Jessica Carracedo, Arkatiz Scheideler, Marcel llyas, Zabran Bauer, Robert C. Erusalimsky, Jorge D. Grzesik, Dominika Salamanca-Viloria, Juan Lv, Xiaoxi Jin, Yishi Li, Ke Velasco, Guillermo Shang, Shuang Lizcano, Jose M. Zhang, Xiaowei Zhou, Jichao Yu, Jiaojiao Hua, Fang Wang, Feng Liu, Shanshan Yu, Jinmei Hu, Zhuowei |
author_role |
author |
author2 |
Eyers, Patrick A. Dobens, Leonard L. Tan, Nguan Soon Mace, Peter D. Link, Wolfgang Kiss-Toth, Endre Keeshan, Karen Nakamura, Takuro Pear, Warren S. Feseha, Yodit Johnston, Jessica Carracedo, Arkatiz Scheideler, Marcel llyas, Zabran Bauer, Robert C. Erusalimsky, Jorge D. Grzesik, Dominika Salamanca-Viloria, Juan Lv, Xiaoxi Jin, Yishi Li, Ke Velasco, Guillermo Shang, Shuang Lizcano, Jose M. Zhang, Xiaowei Zhou, Jichao Yu, Jiaojiao Hua, Fang Wang, Feng Liu, Shanshan Yu, Jinmei Hu, Zhuowei |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Cui, Bing Eyers, Patrick A. Dobens, Leonard L. Tan, Nguan Soon Mace, Peter D. Link, Wolfgang Kiss-Toth, Endre Keeshan, Karen Nakamura, Takuro Pear, Warren S. Feseha, Yodit Johnston, Jessica Carracedo, Arkatiz Scheideler, Marcel llyas, Zabran Bauer, Robert C. Erusalimsky, Jorge D. Grzesik, Dominika Salamanca-Viloria, Juan Lv, Xiaoxi Jin, Yishi Li, Ke Velasco, Guillermo Shang, Shuang Lizcano, Jose M. Zhang, Xiaowei Zhou, Jichao Yu, Jiaojiao Hua, Fang Wang, Feng Liu, Shanshan Yu, Jinmei Hu, Zhuowei |
dc.subject.por.fl_str_mv |
Tribbles Immunology Metabolism Cell biology Kinase inhibitor Tumorigenesis Metastasis TRIB1 TRIB2 TRIB3 Pseudokinase Inflammation Atomic structure Protein quality control Ubiqutin |
topic |
Tribbles Immunology Metabolism Cell biology Kinase inhibitor Tumorigenesis Metastasis TRIB1 TRIB2 TRIB3 Pseudokinase Inflammation Atomic structure Protein quality control Ubiqutin |
description |
The Tribbles (TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2nd International Symposium on Tribbles and Diseases held on May 7-9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. (C) 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-05-21T14:22:27Z 2019 2019-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/12538 |
url |
http://hdl.handle.net/10400.1/12538 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2211-3835 10.1016/j.apsb.2018.12.007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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