Femoral cortical bone in a Portuguese reference skeletal collection

• Autor(a) principal: Cunha, E.
• Data de Publicação: 2017
• Outros Autores: Curate, Francisco
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/108097; https://doi.org/10.14195/2182-7982_34_5
• topic: Radiogrammetry; dual x-ray absorptiometry; periosteal apposition; endosteal resorption; Coimbra Identified Skeletal Collection; Radiogrametria; absorciometria radiológica de dupla energia; aposição periosteal; absorção endosteal; Colecção de Esqueletos Identificados

This study aims to investigate patterns of femoral cortical bone fragility with age (at death) and to evaluate its associations with sex and bone mineral density. Radiogrammetric parameters of the femur and bone mineral density at the proximal femur were assessed in an adult sample (N=98) from the Coimbra Identified Skeletal Collection (Portugal). Diaphysis total width (DTW), femoral cortical index (FEMCI) and bone mineral density (BMD) are significantly higher in males, while medullary width (MW) is not statistically different between sexes. Cortical bone parameters of the femoral diaphysis are associated with age only in women, whereas BMD decreases with age in both sexes. The evaluation of femoral cortical bone reveals sex-specific trajectories of endosteal bone loss and periosteal apposition, stemming from sexual differences in the rate and pattern of bone loss, and in bone size. In females, endocortical bone loss rises with age, particularly in peri- and postmenopausal years, decelerating later in life. Concomitantly, accretion of bone in the subperiosteal surface persists throughout adulthood — partially offsetting bone fragility in women. Strength in the femoral mid-diaphysis appears to be preserved throughout most of the life course in both sexes.