Indeterminate cell histiocytosis in association with acute myeloid leukemia

Detalhes bibliográficos
Autor(a) principal: Ventura, F
Data de Publicação: 2010
Outros Autores: Pereira, T, Duarte, ML, Marques, H, Pardal, F, Brito, C
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.23/103
Resumo: Indeterminate cell histiocytosis (ICH) is a rare proliferative disorder, in which the predominant cells share morphologic and immunophenotypic features from both Langerhans and non-Langerhans cell histiocytosis. We describe a 62-year-old man presenting a 2-month history of firm nodular lesions on the upper lip. Histopathology, immunohistochemical, and ultrastructural analysis showed typical findings of ICH. The patient was treated with thalidomide and almost complete regression of the lesions was reached within 7 months. Nevertheless, one month after remission, he developed an acute myeloid leukemia of the subtype monocytic leukemia (M5). The patient's condition rapidly worsened and he died due to a respiratory failure four weeks later. We present this case because apart of being rare it joins the effectiveness of thalidomide and the association with an acute monocytic leukemia. A review of the literature is made.
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spelling Indeterminate cell histiocytosis in association with acute myeloid leukemiaHistiocitoseLeucemia Mielóide AgudaIndeterminate cell histiocytosis (ICH) is a rare proliferative disorder, in which the predominant cells share morphologic and immunophenotypic features from both Langerhans and non-Langerhans cell histiocytosis. We describe a 62-year-old man presenting a 2-month history of firm nodular lesions on the upper lip. Histopathology, immunohistochemical, and ultrastructural analysis showed typical findings of ICH. The patient was treated with thalidomide and almost complete regression of the lesions was reached within 7 months. Nevertheless, one month after remission, he developed an acute myeloid leukemia of the subtype monocytic leukemia (M5). The patient's condition rapidly worsened and he died due to a respiratory failure four weeks later. We present this case because apart of being rare it joins the effectiveness of thalidomide and the association with an acute monocytic leukemia. A review of the literature is made.HindawiRepositório Científico do Hospital de BragaVentura, FPereira, TDuarte, MLMarques, HPardal, FBrito, C2012-01-13T14:15:28Z2010-01-01T00:00:00Z2010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.23/103engDermatol Res Pract. 2010:569345info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-21T09:01:35Zoai:repositorio.hospitaldebraga.pt:10400.23/103Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:54:08.990489Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Indeterminate cell histiocytosis in association with acute myeloid leukemia
title Indeterminate cell histiocytosis in association with acute myeloid leukemia
spellingShingle Indeterminate cell histiocytosis in association with acute myeloid leukemia
Ventura, F
Histiocitose
Leucemia Mielóide Aguda
title_short Indeterminate cell histiocytosis in association with acute myeloid leukemia
title_full Indeterminate cell histiocytosis in association with acute myeloid leukemia
title_fullStr Indeterminate cell histiocytosis in association with acute myeloid leukemia
title_full_unstemmed Indeterminate cell histiocytosis in association with acute myeloid leukemia
title_sort Indeterminate cell histiocytosis in association with acute myeloid leukemia
author Ventura, F
author_facet Ventura, F
Pereira, T
Duarte, ML
Marques, H
Pardal, F
Brito, C
author_role author
author2 Pereira, T
Duarte, ML
Marques, H
Pardal, F
Brito, C
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Hospital de Braga
dc.contributor.author.fl_str_mv Ventura, F
Pereira, T
Duarte, ML
Marques, H
Pardal, F
Brito, C
dc.subject.por.fl_str_mv Histiocitose
Leucemia Mielóide Aguda
topic Histiocitose
Leucemia Mielóide Aguda
description Indeterminate cell histiocytosis (ICH) is a rare proliferative disorder, in which the predominant cells share morphologic and immunophenotypic features from both Langerhans and non-Langerhans cell histiocytosis. We describe a 62-year-old man presenting a 2-month history of firm nodular lesions on the upper lip. Histopathology, immunohistochemical, and ultrastructural analysis showed typical findings of ICH. The patient was treated with thalidomide and almost complete regression of the lesions was reached within 7 months. Nevertheless, one month after remission, he developed an acute myeloid leukemia of the subtype monocytic leukemia (M5). The patient's condition rapidly worsened and he died due to a respiratory failure four weeks later. We present this case because apart of being rare it joins the effectiveness of thalidomide and the association with an acute monocytic leukemia. A review of the literature is made.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01T00:00:00Z
2010-01-01T00:00:00Z
2012-01-13T14:15:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.23/103
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv Dermatol Res Pract. 2010:569345
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dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
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