Fabrication of quasi-2D shape-tailored microparticles using wettability contrast-based platforms

Detalhes bibliográficos
Autor(a) principal: Neto, Mafalda D.
Data de Publicação: 2021
Outros Autores: Stoppa, Aukha, Neto, Miguel A., Oliveira, Filipe J., Gomes, Maria C., Boccaccini, Aldo R., Levkin, Pavel A., Oliveira, Mariana B., Mano, João F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/34374
Resumo: The ability to fabricate materials with ultrathin architectures enables the breakthrough of low-dimensional structures with high surface area that showcase distinctive properties from their bulk counterparts. They are exploited in a wide range of fields, including energy harvesting, catalysis, and biomedicine. Despite such versatility, the fine tuning of the lateral dimensions and geometry of these structures remains challenging. Prepatterned platforms gain significant attention as enabling technologies to process materials with highly controlled shapes and dimensions. Herein, different nanometer-thick particles of various lateral sizes and geometries (e.g., squares, circles, triangles, hexagons) are processed with high precision and definition, taking advantage of the wettability contrast of oleophilic-oleophobic patterned surfaces. Quasi-2D polymeric microparticles with high shape- and size-fidelity can be retrieved as freestanding objects in a single step. These structures show cell-mediated pliability, and their integration in gravity-enforced human adipose-derived stem cell spheroids leads to an enhanced metabolic activity and a modulated secretion of proangiogenic factors.
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spelling Fabrication of quasi-2D shape-tailored microparticles using wettability contrast-based platformsBioinspired surfacesOleophobic patterned surfacesQuasi-2D nanostructuresUltrathin microparticlesWettable–dewettable contrastThe ability to fabricate materials with ultrathin architectures enables the breakthrough of low-dimensional structures with high surface area that showcase distinctive properties from their bulk counterparts. They are exploited in a wide range of fields, including energy harvesting, catalysis, and biomedicine. Despite such versatility, the fine tuning of the lateral dimensions and geometry of these structures remains challenging. Prepatterned platforms gain significant attention as enabling technologies to process materials with highly controlled shapes and dimensions. Herein, different nanometer-thick particles of various lateral sizes and geometries (e.g., squares, circles, triangles, hexagons) are processed with high precision and definition, taking advantage of the wettability contrast of oleophilic-oleophobic patterned surfaces. Quasi-2D polymeric microparticles with high shape- and size-fidelity can be retrieved as freestanding objects in a single step. These structures show cell-mediated pliability, and their integration in gravity-enforced human adipose-derived stem cell spheroids leads to an enhanced metabolic activity and a modulated secretion of proangiogenic factors.Wiley2022-08-02T17:43:51Z2021-04-08T00:00:00Z2021-04-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/34374eng0935-964810.1002/adma.202007695Neto, Mafalda D.Stoppa, AukhaNeto, Miguel A.Oliveira, Filipe J.Gomes, Maria C.Boccaccini, Aldo R.Levkin, Pavel A.Oliveira, Mariana B.Mano, João F.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:06:25Zoai:ria.ua.pt:10773/34374Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:05:44.221206Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Fabrication of quasi-2D shape-tailored microparticles using wettability contrast-based platforms
title Fabrication of quasi-2D shape-tailored microparticles using wettability contrast-based platforms
spellingShingle Fabrication of quasi-2D shape-tailored microparticles using wettability contrast-based platforms
Neto, Mafalda D.
Bioinspired surfaces
Oleophobic patterned surfaces
Quasi-2D nanostructures
Ultrathin microparticles
Wettable–dewettable contrast
title_short Fabrication of quasi-2D shape-tailored microparticles using wettability contrast-based platforms
title_full Fabrication of quasi-2D shape-tailored microparticles using wettability contrast-based platforms
title_fullStr Fabrication of quasi-2D shape-tailored microparticles using wettability contrast-based platforms
title_full_unstemmed Fabrication of quasi-2D shape-tailored microparticles using wettability contrast-based platforms
title_sort Fabrication of quasi-2D shape-tailored microparticles using wettability contrast-based platforms
author Neto, Mafalda D.
author_facet Neto, Mafalda D.
Stoppa, Aukha
Neto, Miguel A.
Oliveira, Filipe J.
Gomes, Maria C.
Boccaccini, Aldo R.
Levkin, Pavel A.
Oliveira, Mariana B.
Mano, João F.
author_role author
author2 Stoppa, Aukha
Neto, Miguel A.
Oliveira, Filipe J.
Gomes, Maria C.
Boccaccini, Aldo R.
Levkin, Pavel A.
Oliveira, Mariana B.
Mano, João F.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Neto, Mafalda D.
Stoppa, Aukha
Neto, Miguel A.
Oliveira, Filipe J.
Gomes, Maria C.
Boccaccini, Aldo R.
Levkin, Pavel A.
Oliveira, Mariana B.
Mano, João F.
dc.subject.por.fl_str_mv Bioinspired surfaces
Oleophobic patterned surfaces
Quasi-2D nanostructures
Ultrathin microparticles
Wettable–dewettable contrast
topic Bioinspired surfaces
Oleophobic patterned surfaces
Quasi-2D nanostructures
Ultrathin microparticles
Wettable–dewettable contrast
description The ability to fabricate materials with ultrathin architectures enables the breakthrough of low-dimensional structures with high surface area that showcase distinctive properties from their bulk counterparts. They are exploited in a wide range of fields, including energy harvesting, catalysis, and biomedicine. Despite such versatility, the fine tuning of the lateral dimensions and geometry of these structures remains challenging. Prepatterned platforms gain significant attention as enabling technologies to process materials with highly controlled shapes and dimensions. Herein, different nanometer-thick particles of various lateral sizes and geometries (e.g., squares, circles, triangles, hexagons) are processed with high precision and definition, taking advantage of the wettability contrast of oleophilic-oleophobic patterned surfaces. Quasi-2D polymeric microparticles with high shape- and size-fidelity can be retrieved as freestanding objects in a single step. These structures show cell-mediated pliability, and their integration in gravity-enforced human adipose-derived stem cell spheroids leads to an enhanced metabolic activity and a modulated secretion of proangiogenic factors.
publishDate 2021
dc.date.none.fl_str_mv 2021-04-08T00:00:00Z
2021-04-08
2022-08-02T17:43:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/34374
url http://hdl.handle.net/10773/34374
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0935-9648
10.1002/adma.202007695
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
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