Epithelioid Trophoblastic Tumour

Detalhes bibliográficos
Autor(a) principal: Pisani, David
Data de Publicação: 2021
Outros Autores: Calleja-Agius, Jean, Di Fiore, Riccardo, O'Leary, John J, Beirne, James P, O'Toole, Sharon A, Felix, Ana, Said-Huntingford, Ian
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/131479
Resumo: Funding: This article is based upon work from COST Action CA18117—European network for Gynaecological Rare Cancer research: From Concept to Cure (GYNOCARE), supported by COST (European Cooperation in Science and Technology). COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. www.cost.eu (accessed on 25 October 2021).
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spelling Epithelioid Trophoblastic TumourA Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated with Surgery and PembrolizumabEpithelioid trophoblastic tumourGestational trophoblastic tumourRare gynaecological tumourFunding: This article is based upon work from COST Action CA18117—European network for Gynaecological Rare Cancer research: From Concept to Cure (GYNOCARE), supported by COST (European Cooperation in Science and Technology). COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. www.cost.eu (accessed on 25 October 2021).Epithelioid trophoblastic tumours are rare neoplasms showing differentiation towards the chorion leave-type intermediate cytotrophoblast, with only a handful of cases being reported in the literature. These tumours are slow-growing and are typically confined to the uterus for extended periods of time. While the pathogenesis is unclear, they are thought to arise from a remnant intermediate trophoblast originating from prior normal pregnancies or, less frequently, gestational trophoblastic tumours. A protracted time period between the gestational event and tumour development is typical. This case describes a 49-year-old previously healthy female who presented with a completely asymptomatic uterine mass, discovered incidentally during a routine gynaecological assessment. The pathological analysis of the hysterectomy specimen confirmed an epithelioid trophoblastic tumour, involving the uterus and cervix. This is a rare gynaecological tumour. A comparative short tandem repeat analysis revealed genetic similarities to a previous healthy gestation seventeen years prior. She was successful treated with adjuvant pembrolizumab, with no evidence of disease recurrence to date.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNPisani, DavidCalleja-Agius, JeanDi Fiore, RiccardoO'Leary, John JBeirne, James PO'Toole, Sharon AFelix, AnaSaid-Huntingford, Ian2022-01-25T03:30:21Z2021-12-132021-12-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttp://hdl.handle.net/10362/131479eng1198-0052PURE: 36219532https://doi.org/10.3390/curroncol28060446info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:10:03Zoai:run.unl.pt:10362/131479Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:47:04.805256Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Epithelioid Trophoblastic Tumour
A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated with Surgery and Pembrolizumab
title Epithelioid Trophoblastic Tumour
spellingShingle Epithelioid Trophoblastic Tumour
Pisani, David
Epithelioid trophoblastic tumour
Gestational trophoblastic tumour
Rare gynaecological tumour
title_short Epithelioid Trophoblastic Tumour
title_full Epithelioid Trophoblastic Tumour
title_fullStr Epithelioid Trophoblastic Tumour
title_full_unstemmed Epithelioid Trophoblastic Tumour
title_sort Epithelioid Trophoblastic Tumour
author Pisani, David
author_facet Pisani, David
Calleja-Agius, Jean
Di Fiore, Riccardo
O'Leary, John J
Beirne, James P
O'Toole, Sharon A
Felix, Ana
Said-Huntingford, Ian
author_role author
author2 Calleja-Agius, Jean
Di Fiore, Riccardo
O'Leary, John J
Beirne, James P
O'Toole, Sharon A
Felix, Ana
Said-Huntingford, Ian
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Pisani, David
Calleja-Agius, Jean
Di Fiore, Riccardo
O'Leary, John J
Beirne, James P
O'Toole, Sharon A
Felix, Ana
Said-Huntingford, Ian
dc.subject.por.fl_str_mv Epithelioid trophoblastic tumour
Gestational trophoblastic tumour
Rare gynaecological tumour
topic Epithelioid trophoblastic tumour
Gestational trophoblastic tumour
Rare gynaecological tumour
description Funding: This article is based upon work from COST Action CA18117—European network for Gynaecological Rare Cancer research: From Concept to Cure (GYNOCARE), supported by COST (European Cooperation in Science and Technology). COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. www.cost.eu (accessed on 25 October 2021).
publishDate 2021
dc.date.none.fl_str_mv 2021-12-13
2021-12-13T00:00:00Z
2022-01-25T03:30:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/131479
url http://hdl.handle.net/10362/131479
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1198-0052
PURE: 36219532
https://doi.org/10.3390/curroncol28060446
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10
application/pdf
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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