On the progress of hydrogel-based 3D printing: Correlating rheological properties with printing behaviour
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/58913 |
Resumo: | One of the exciting future directions in the 3D printing field is the development of innovative personalized smart constructions for bio-applications, including drug delivery, namely high-throughput drug screening and customized topical/oral administration of pharmaceuticals, as well as tissue engineering. In this context, hydrogels have emerged as a promising material that, when combined with extrusion 3D printing, allow the creation of soft-material structures with defined spatial locations, that can be printed at room temperature and customized by tuning the geometric design and/or the formulation components. Thus, the efficacy and quality of such vehicles is dependent on formulation, design, and printing process parameters. However, hydrogel inks are often designed and characterized using different methods and this lack of uniformity impairs. Characterization techniques are usually arbitrary and differ among research groups, challenging the inference of possible conclusions on hydrogel behaviour and potential applications. Therefore, to properly analyse the potential of a particular hydrogel ink formulation, we review, for the first time, the most frequently employed characterization procedures, from rheological approaches to printing parameters and settings, and discuss their relevance, limitations and drawbacks, and highlight future perspectives. Overall, to accelerate the development of high-quality 3D constructs, comprehensive characterization protocols for both pre-printing and printing assays should be adopted. Furthermore, their transversal adoption could serve as a boost in terms of quality requirements and regulatory aspects. |
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On the progress of hydrogel-based 3D printing: Correlating rheological properties with printing behaviourPrintabilityExtrudabilityPrinting accuracyShape fidelityPrinting precisionOne of the exciting future directions in the 3D printing field is the development of innovative personalized smart constructions for bio-applications, including drug delivery, namely high-throughput drug screening and customized topical/oral administration of pharmaceuticals, as well as tissue engineering. In this context, hydrogels have emerged as a promising material that, when combined with extrusion 3D printing, allow the creation of soft-material structures with defined spatial locations, that can be printed at room temperature and customized by tuning the geometric design and/or the formulation components. Thus, the efficacy and quality of such vehicles is dependent on formulation, design, and printing process parameters. However, hydrogel inks are often designed and characterized using different methods and this lack of uniformity impairs. Characterization techniques are usually arbitrary and differ among research groups, challenging the inference of possible conclusions on hydrogel behaviour and potential applications. Therefore, to properly analyse the potential of a particular hydrogel ink formulation, we review, for the first time, the most frequently employed characterization procedures, from rheological approaches to printing parameters and settings, and discuss their relevance, limitations and drawbacks, and highlight future perspectives. Overall, to accelerate the development of high-quality 3D constructs, comprehensive characterization protocols for both pre-printing and printing assays should be adopted. Furthermore, their transversal adoption could serve as a boost in terms of quality requirements and regulatory aspects.This research was funded by the Fundação para a Ciência e Tecnologia, Portugal (UIDB/04138/2020 and UIDP/04138/2020 to iMed.ULisboa, PTDC/MEC-DER/30198/2017 and CEECINST/00145/2018 to J.Marto, and CQE UIDB/QUI/00100/2020 to C.Santos. S.Bom was supported by a PhD fellowship (3DGelComp project) from Instituto Politécnico de Setubal.ElsevierRepositório da Universidade de LisboaBom, SaraRibeiro, RicardoRibeiro, HelenaSantos, CatarinaMarto, Joana2023-08-17T14:55:55Z2022-032022-12-17T15:52:47Z2022-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/58913engBom S, Ribeiro R, Ribeiro HM, Santos C, Marto J. On the progress of hydrogel-based 3D printing: Correlating rheological properties with printing behaviour. International Journal of Pharmaceutics [Internet]. 5 de março de 2022;615:121506. Disponível em: https://www.sciencedirect.com/science/article/pii/S037851732200059X0378-5173cv-prod-285189010.1016/j.ijpharm.2022.121506info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:02:25Zoai:repositorio.ul.pt:10451/58913Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:06:06.083374Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
On the progress of hydrogel-based 3D printing: Correlating rheological properties with printing behaviour |
title |
On the progress of hydrogel-based 3D printing: Correlating rheological properties with printing behaviour |
spellingShingle |
On the progress of hydrogel-based 3D printing: Correlating rheological properties with printing behaviour Bom, Sara Printability Extrudability Printing accuracy Shape fidelity Printing precision |
title_short |
On the progress of hydrogel-based 3D printing: Correlating rheological properties with printing behaviour |
title_full |
On the progress of hydrogel-based 3D printing: Correlating rheological properties with printing behaviour |
title_fullStr |
On the progress of hydrogel-based 3D printing: Correlating rheological properties with printing behaviour |
title_full_unstemmed |
On the progress of hydrogel-based 3D printing: Correlating rheological properties with printing behaviour |
title_sort |
On the progress of hydrogel-based 3D printing: Correlating rheological properties with printing behaviour |
author |
Bom, Sara |
author_facet |
Bom, Sara Ribeiro, Ricardo Ribeiro, Helena Santos, Catarina Marto, Joana |
author_role |
author |
author2 |
Ribeiro, Ricardo Ribeiro, Helena Santos, Catarina Marto, Joana |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Bom, Sara Ribeiro, Ricardo Ribeiro, Helena Santos, Catarina Marto, Joana |
dc.subject.por.fl_str_mv |
Printability Extrudability Printing accuracy Shape fidelity Printing precision |
topic |
Printability Extrudability Printing accuracy Shape fidelity Printing precision |
description |
One of the exciting future directions in the 3D printing field is the development of innovative personalized smart constructions for bio-applications, including drug delivery, namely high-throughput drug screening and customized topical/oral administration of pharmaceuticals, as well as tissue engineering. In this context, hydrogels have emerged as a promising material that, when combined with extrusion 3D printing, allow the creation of soft-material structures with defined spatial locations, that can be printed at room temperature and customized by tuning the geometric design and/or the formulation components. Thus, the efficacy and quality of such vehicles is dependent on formulation, design, and printing process parameters. However, hydrogel inks are often designed and characterized using different methods and this lack of uniformity impairs. Characterization techniques are usually arbitrary and differ among research groups, challenging the inference of possible conclusions on hydrogel behaviour and potential applications. Therefore, to properly analyse the potential of a particular hydrogel ink formulation, we review, for the first time, the most frequently employed characterization procedures, from rheological approaches to printing parameters and settings, and discuss their relevance, limitations and drawbacks, and highlight future perspectives. Overall, to accelerate the development of high-quality 3D constructs, comprehensive characterization protocols for both pre-printing and printing assays should be adopted. Furthermore, their transversal adoption could serve as a boost in terms of quality requirements and regulatory aspects. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03 2022-12-17T15:52:47Z 2022-03-01T00:00:00Z 2023-08-17T14:55:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/58913 |
url |
http://hdl.handle.net/10451/58913 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Bom S, Ribeiro R, Ribeiro HM, Santos C, Marto J. On the progress of hydrogel-based 3D printing: Correlating rheological properties with printing behaviour. International Journal of Pharmaceutics [Internet]. 5 de março de 2022;615:121506. Disponível em: https://www.sciencedirect.com/science/article/pii/S037851732200059X 0378-5173 cv-prod-2851890 10.1016/j.ijpharm.2022.121506 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134613841379328 |