Emulsion crosslinking as a new manufacturing route to produce hydroxylapatite particulates in a network of starch
Autor(a) principal: | |
---|---|
Data de Publicação: | 2001 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/14221 |
Resumo: | Bioactive particulates with tailored resorption rates can be very useful on biomedical applications such as filling of bone and dentristy defects, carriers for controlled release of bioactive agents and reinforcement in polymer/bioceramic orthopaedic composites. The aim of the present study was to develop a new processing route to produce composite particulates based on hydroxylapatite (HA) and starch. The newly proposed processing route consists on the crosslinking of starch that is able to encapsulate the HA particles creating a composite material with different sizes (from 3000-700 um) which is resorbable and bioactive. This work also involves the characterization of the developed material, as well as the study of the in-vitro degradation and bioactive behaviour of the particulates. The particulate biomaterials have shown to be bioactive even after small immersion periods on a simulated body fluid (SBF). The obtained results (in-vitro) indicate that particulates will be expected to be resorbed when implanted. The developed materials present an interesting combination of morphological and chemical properties that make them potential biomaterials to be used as fillers of bone defects, drug delivery carriers or as reinforcement of bioactive starch-based composites. |
id |
RCAP_d42147830a06ee3373ec11464eb5781b |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/14221 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Emulsion crosslinking as a new manufacturing route to produce hydroxylapatite particulates in a network of starchBioactiveCalcium phosphateCarrier pillersParticulateReinforcementcarrierfillersScience & TechnologyBioactive particulates with tailored resorption rates can be very useful on biomedical applications such as filling of bone and dentristy defects, carriers for controlled release of bioactive agents and reinforcement in polymer/bioceramic orthopaedic composites. The aim of the present study was to develop a new processing route to produce composite particulates based on hydroxylapatite (HA) and starch. The newly proposed processing route consists on the crosslinking of starch that is able to encapsulate the HA particles creating a composite material with different sizes (from 3000-700 um) which is resorbable and bioactive. This work also involves the characterization of the developed material, as well as the study of the in-vitro degradation and bioactive behaviour of the particulates. The particulate biomaterials have shown to be bioactive even after small immersion periods on a simulated body fluid (SBF). The obtained results (in-vitro) indicate that particulates will be expected to be resorbed when implanted. The developed materials present an interesting combination of morphological and chemical properties that make them potential biomaterials to be used as fillers of bone defects, drug delivery carriers or as reinforcement of bioactive starch-based composites.(undefined)Trans Tech PublicationsUniversidade do MinhoMalafaya, P. B.Stappers, FrankReis, R. L.20012001-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/14221engMalafaya, P. B., Stappers, F., & Reis, R. L. (2000, September). Emulsion Crosslinking as a New Manufacturing Route to Produce Hydroxylapatite Particulates in a Network of Starch. Key Engineering Materials. Trans Tech Publications, Ltd. http://doi.org/10.4028/www.scientific.net/kem.192-195.243978-0-87849-866-61013-982610.4028/www.scientific.net/KEM.192-195.243https://www.scientific.net/KEM.192-195.243info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-07-27T01:23:20Zoai:repositorium.sdum.uminho.pt:1822/14221Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-07-27T01:23:20Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Emulsion crosslinking as a new manufacturing route to produce hydroxylapatite particulates in a network of starch |
title |
Emulsion crosslinking as a new manufacturing route to produce hydroxylapatite particulates in a network of starch |
spellingShingle |
Emulsion crosslinking as a new manufacturing route to produce hydroxylapatite particulates in a network of starch Malafaya, P. B. Bioactive Calcium phosphate Carrier pillers Particulate Reinforcement carrier fillers Science & Technology |
title_short |
Emulsion crosslinking as a new manufacturing route to produce hydroxylapatite particulates in a network of starch |
title_full |
Emulsion crosslinking as a new manufacturing route to produce hydroxylapatite particulates in a network of starch |
title_fullStr |
Emulsion crosslinking as a new manufacturing route to produce hydroxylapatite particulates in a network of starch |
title_full_unstemmed |
Emulsion crosslinking as a new manufacturing route to produce hydroxylapatite particulates in a network of starch |
title_sort |
Emulsion crosslinking as a new manufacturing route to produce hydroxylapatite particulates in a network of starch |
author |
Malafaya, P. B. |
author_facet |
Malafaya, P. B. Stappers, Frank Reis, R. L. |
author_role |
author |
author2 |
Stappers, Frank Reis, R. L. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Malafaya, P. B. Stappers, Frank Reis, R. L. |
dc.subject.por.fl_str_mv |
Bioactive Calcium phosphate Carrier pillers Particulate Reinforcement carrier fillers Science & Technology |
topic |
Bioactive Calcium phosphate Carrier pillers Particulate Reinforcement carrier fillers Science & Technology |
description |
Bioactive particulates with tailored resorption rates can be very useful on biomedical applications such as filling of bone and dentristy defects, carriers for controlled release of bioactive agents and reinforcement in polymer/bioceramic orthopaedic composites. The aim of the present study was to develop a new processing route to produce composite particulates based on hydroxylapatite (HA) and starch. The newly proposed processing route consists on the crosslinking of starch that is able to encapsulate the HA particles creating a composite material with different sizes (from 3000-700 um) which is resorbable and bioactive. This work also involves the characterization of the developed material, as well as the study of the in-vitro degradation and bioactive behaviour of the particulates. The particulate biomaterials have shown to be bioactive even after small immersion periods on a simulated body fluid (SBF). The obtained results (in-vitro) indicate that particulates will be expected to be resorbed when implanted. The developed materials present an interesting combination of morphological and chemical properties that make them potential biomaterials to be used as fillers of bone defects, drug delivery carriers or as reinforcement of bioactive starch-based composites. |
publishDate |
2001 |
dc.date.none.fl_str_mv |
2001 2001-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/14221 |
url |
https://hdl.handle.net/1822/14221 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Malafaya, P. B., Stappers, F., & Reis, R. L. (2000, September). Emulsion Crosslinking as a New Manufacturing Route to Produce Hydroxylapatite Particulates in a Network of Starch. Key Engineering Materials. Trans Tech Publications, Ltd. http://doi.org/10.4028/www.scientific.net/kem.192-195.243 978-0-87849-866-6 1013-9826 10.4028/www.scientific.net/KEM.192-195.243 https://www.scientific.net/KEM.192-195.243 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Trans Tech Publications |
publisher.none.fl_str_mv |
Trans Tech Publications |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
_version_ |
1817545127606878208 |