Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge

Detalhes bibliográficos
Autor(a) principal: Stone, Vicki
Data de Publicação: 2017
Outros Autores: Miller, Mark R., Clift, Martin J.D., Elder, Alison, Mills, Nicholas L., Møller, Peter, Schins, Roel P.F., Vogel, Ulla, Kreyling, Wolfgang G., Alstrup Jensen, Keld, Kuhlbusch, Thomas A.J., Schwarze, Per E., Hoet, Peter, Pietroiusti, Antonio, De Vizcaya-Ruiz, Andrea, Baeza-Squiban, Armelle, Teixeira, João Paulo, Tran, C. Lang, Cassee, Flemming R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/4798
Resumo: BACKGROUND: A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis. Therefore, the study of ultrafine particles (UFP, <100 nm in diameter) provides an opportunity to identify plausible health effects for NMs, and the study of NMs provides an opportunity to facilitate the understanding of the mechanism of toxicity of UFP. METHODS: A workshop of experts systematically analyzed the available information and identified 19 key lessons that can facilitate knowledge exchange between these discipline areas. DISCUSSION: Key lessons range from the availability of specific techniques and standard protocols for physicochemical characterization and toxicology assessment to understanding and defining dose and the molecular mechanisms of toxicity. This review identifies a number of key areas in which additional research prioritization would facilitate both research fields simultaneously. CONCLUSION: There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa.
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spelling Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledgeNanomaterialsToxicologyAmbient Ultrafine ParticlesHealth RiskReview of LiteratureBACKGROUND: A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis. Therefore, the study of ultrafine particles (UFP, <100 nm in diameter) provides an opportunity to identify plausible health effects for NMs, and the study of NMs provides an opportunity to facilitate the understanding of the mechanism of toxicity of UFP. METHODS: A workshop of experts systematically analyzed the available information and identified 19 key lessons that can facilitate knowledge exchange between these discipline areas. DISCUSSION: Key lessons range from the availability of specific techniques and standard protocols for physicochemical characterization and toxicology assessment to understanding and defining dose and the molecular mechanisms of toxicity. This review identifies a number of key areas in which additional research prioritization would facilitate both research fields simultaneously. CONCLUSION: There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa.National Institute of Environmental Health Sciences (NIEHS)Repositório Científico do Instituto Nacional de SaúdeStone, VickiMiller, Mark R.Clift, Martin J.D.Elder, AlisonMills, Nicholas L.Møller, PeterSchins, Roel P.F.Vogel, UllaKreyling, Wolfgang G.Alstrup Jensen, KeldKuhlbusch, Thomas A.J.Schwarze, Per E.Hoet, PeterPietroiusti, AntonioDe Vizcaya-Ruiz, AndreaBaeza-Squiban, ArmelleTeixeira, João PauloTran, C. LangCassee, Flemming R.2017-10-26T12:37:53Z2017-10-102017-10-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4798engEnviron Health Perspect. 2017 Oct 10;125(10):106002. doi: 10.1289/EHP4240091-676510.1289/EHP424info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:34Zoai:repositorio.insa.pt:10400.18/4798Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:37.708821Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge
title Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge
spellingShingle Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge
Stone, Vicki
Nanomaterials
Toxicology
Ambient Ultrafine Particles
Health Risk
Review of Literature
title_short Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge
title_full Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge
title_fullStr Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge
title_full_unstemmed Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge
title_sort Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge
author Stone, Vicki
author_facet Stone, Vicki
Miller, Mark R.
Clift, Martin J.D.
Elder, Alison
Mills, Nicholas L.
Møller, Peter
Schins, Roel P.F.
Vogel, Ulla
Kreyling, Wolfgang G.
Alstrup Jensen, Keld
Kuhlbusch, Thomas A.J.
Schwarze, Per E.
Hoet, Peter
Pietroiusti, Antonio
De Vizcaya-Ruiz, Andrea
Baeza-Squiban, Armelle
Teixeira, João Paulo
Tran, C. Lang
Cassee, Flemming R.
author_role author
author2 Miller, Mark R.
Clift, Martin J.D.
Elder, Alison
Mills, Nicholas L.
Møller, Peter
Schins, Roel P.F.
Vogel, Ulla
Kreyling, Wolfgang G.
Alstrup Jensen, Keld
Kuhlbusch, Thomas A.J.
Schwarze, Per E.
Hoet, Peter
Pietroiusti, Antonio
De Vizcaya-Ruiz, Andrea
Baeza-Squiban, Armelle
Teixeira, João Paulo
Tran, C. Lang
Cassee, Flemming R.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Stone, Vicki
Miller, Mark R.
Clift, Martin J.D.
Elder, Alison
Mills, Nicholas L.
Møller, Peter
Schins, Roel P.F.
Vogel, Ulla
Kreyling, Wolfgang G.
Alstrup Jensen, Keld
Kuhlbusch, Thomas A.J.
Schwarze, Per E.
Hoet, Peter
Pietroiusti, Antonio
De Vizcaya-Ruiz, Andrea
Baeza-Squiban, Armelle
Teixeira, João Paulo
Tran, C. Lang
Cassee, Flemming R.
dc.subject.por.fl_str_mv Nanomaterials
Toxicology
Ambient Ultrafine Particles
Health Risk
Review of Literature
topic Nanomaterials
Toxicology
Ambient Ultrafine Particles
Health Risk
Review of Literature
description BACKGROUND: A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis. Therefore, the study of ultrafine particles (UFP, <100 nm in diameter) provides an opportunity to identify plausible health effects for NMs, and the study of NMs provides an opportunity to facilitate the understanding of the mechanism of toxicity of UFP. METHODS: A workshop of experts systematically analyzed the available information and identified 19 key lessons that can facilitate knowledge exchange between these discipline areas. DISCUSSION: Key lessons range from the availability of specific techniques and standard protocols for physicochemical characterization and toxicology assessment to understanding and defining dose and the molecular mechanisms of toxicity. This review identifies a number of key areas in which additional research prioritization would facilitate both research fields simultaneously. CONCLUSION: There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-26T12:37:53Z
2017-10-10
2017-10-10T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/4798
url http://hdl.handle.net/10400.18/4798
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Environ Health Perspect. 2017 Oct 10;125(10):106002. doi: 10.1289/EHP424
0091-6765
10.1289/EHP424
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv National Institute of Environmental Health Sciences (NIEHS)
publisher.none.fl_str_mv National Institute of Environmental Health Sciences (NIEHS)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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