Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/4798 |
Resumo: | BACKGROUND: A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis. Therefore, the study of ultrafine particles (UFP, <100 nm in diameter) provides an opportunity to identify plausible health effects for NMs, and the study of NMs provides an opportunity to facilitate the understanding of the mechanism of toxicity of UFP. METHODS: A workshop of experts systematically analyzed the available information and identified 19 key lessons that can facilitate knowledge exchange between these discipline areas. DISCUSSION: Key lessons range from the availability of specific techniques and standard protocols for physicochemical characterization and toxicology assessment to understanding and defining dose and the molecular mechanisms of toxicity. This review identifies a number of key areas in which additional research prioritization would facilitate both research fields simultaneously. CONCLUSION: There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa. |
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Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledgeNanomaterialsToxicologyAmbient Ultrafine ParticlesHealth RiskReview of LiteratureBACKGROUND: A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis. Therefore, the study of ultrafine particles (UFP, <100 nm in diameter) provides an opportunity to identify plausible health effects for NMs, and the study of NMs provides an opportunity to facilitate the understanding of the mechanism of toxicity of UFP. METHODS: A workshop of experts systematically analyzed the available information and identified 19 key lessons that can facilitate knowledge exchange between these discipline areas. DISCUSSION: Key lessons range from the availability of specific techniques and standard protocols for physicochemical characterization and toxicology assessment to understanding and defining dose and the molecular mechanisms of toxicity. This review identifies a number of key areas in which additional research prioritization would facilitate both research fields simultaneously. CONCLUSION: There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa.National Institute of Environmental Health Sciences (NIEHS)Repositório Científico do Instituto Nacional de SaúdeStone, VickiMiller, Mark R.Clift, Martin J.D.Elder, AlisonMills, Nicholas L.Møller, PeterSchins, Roel P.F.Vogel, UllaKreyling, Wolfgang G.Alstrup Jensen, KeldKuhlbusch, Thomas A.J.Schwarze, Per E.Hoet, PeterPietroiusti, AntonioDe Vizcaya-Ruiz, AndreaBaeza-Squiban, ArmelleTeixeira, João PauloTran, C. LangCassee, Flemming R.2017-10-26T12:37:53Z2017-10-102017-10-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4798engEnviron Health Perspect. 2017 Oct 10;125(10):106002. doi: 10.1289/EHP4240091-676510.1289/EHP424info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:34Zoai:repositorio.insa.pt:10400.18/4798Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:37.708821Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge |
title |
Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge |
spellingShingle |
Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge Stone, Vicki Nanomaterials Toxicology Ambient Ultrafine Particles Health Risk Review of Literature |
title_short |
Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge |
title_full |
Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge |
title_fullStr |
Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge |
title_full_unstemmed |
Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge |
title_sort |
Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge |
author |
Stone, Vicki |
author_facet |
Stone, Vicki Miller, Mark R. Clift, Martin J.D. Elder, Alison Mills, Nicholas L. Møller, Peter Schins, Roel P.F. Vogel, Ulla Kreyling, Wolfgang G. Alstrup Jensen, Keld Kuhlbusch, Thomas A.J. Schwarze, Per E. Hoet, Peter Pietroiusti, Antonio De Vizcaya-Ruiz, Andrea Baeza-Squiban, Armelle Teixeira, João Paulo Tran, C. Lang Cassee, Flemming R. |
author_role |
author |
author2 |
Miller, Mark R. Clift, Martin J.D. Elder, Alison Mills, Nicholas L. Møller, Peter Schins, Roel P.F. Vogel, Ulla Kreyling, Wolfgang G. Alstrup Jensen, Keld Kuhlbusch, Thomas A.J. Schwarze, Per E. Hoet, Peter Pietroiusti, Antonio De Vizcaya-Ruiz, Andrea Baeza-Squiban, Armelle Teixeira, João Paulo Tran, C. Lang Cassee, Flemming R. |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Stone, Vicki Miller, Mark R. Clift, Martin J.D. Elder, Alison Mills, Nicholas L. Møller, Peter Schins, Roel P.F. Vogel, Ulla Kreyling, Wolfgang G. Alstrup Jensen, Keld Kuhlbusch, Thomas A.J. Schwarze, Per E. Hoet, Peter Pietroiusti, Antonio De Vizcaya-Ruiz, Andrea Baeza-Squiban, Armelle Teixeira, João Paulo Tran, C. Lang Cassee, Flemming R. |
dc.subject.por.fl_str_mv |
Nanomaterials Toxicology Ambient Ultrafine Particles Health Risk Review of Literature |
topic |
Nanomaterials Toxicology Ambient Ultrafine Particles Health Risk Review of Literature |
description |
BACKGROUND: A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis. Therefore, the study of ultrafine particles (UFP, <100 nm in diameter) provides an opportunity to identify plausible health effects for NMs, and the study of NMs provides an opportunity to facilitate the understanding of the mechanism of toxicity of UFP. METHODS: A workshop of experts systematically analyzed the available information and identified 19 key lessons that can facilitate knowledge exchange between these discipline areas. DISCUSSION: Key lessons range from the availability of specific techniques and standard protocols for physicochemical characterization and toxicology assessment to understanding and defining dose and the molecular mechanisms of toxicity. This review identifies a number of key areas in which additional research prioritization would facilitate both research fields simultaneously. CONCLUSION: There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-26T12:37:53Z 2017-10-10 2017-10-10T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/4798 |
url |
http://hdl.handle.net/10400.18/4798 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Environ Health Perspect. 2017 Oct 10;125(10):106002. doi: 10.1289/EHP424 0091-6765 10.1289/EHP424 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
National Institute of Environmental Health Sciences (NIEHS) |
publisher.none.fl_str_mv |
National Institute of Environmental Health Sciences (NIEHS) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132135662026752 |