Endocytosis and intracellular trafficking of nanomaterials

Detalhes bibliográficos
Autor(a) principal: Ferreira, L. A. B.
Data de Publicação: 2015
Outros Autores: Radaic, A., Pugliese, G. O., Valentini, M. B., Oliveira, M. R., de Jesus, M. B.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://actafarmaceuticaportuguesa.com/index.php/afp/article/view/54
Resumo: Recent advances in nanotechnology have increased the use of nanomaterials and nanodevices for diagnostic, therapeutic and other technological applications. The knowledge about the interaction between nanomaterials and biological media allows the development of more rational applications, as well understand and anticipate adverse and toxic effects resulting from this interaction. Endocytosis is an energy-dependent biological process responsible for internalization of nanoparticles, which depends on orchestrated events that require lipids and plasma membrane proteins functioning. Studies that aim to investigate in detail the endocytosis and intracellular trafficking of nanoparticles are essential for understanding cellular mechanisms, which in turn help to select its biomedical applications. In this context, this review aims to conceptualize the main routes of endocytosis used to study the internalization of nanomaterials in eukaryotic cells. In addition, we discuss some intracellular trafficking of nanomaterials to aid in studies of the cellular processing and development of new therapeutic tools.
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spelling Endocytosis and intracellular trafficking of nanomaterialsEndocitose e tráfego intracelular de nanomateriaisendocytosis nanoparticleintracellular traffickingEndocitosenanopartículatráfego intracelularRecent advances in nanotechnology have increased the use of nanomaterials and nanodevices for diagnostic, therapeutic and other technological applications. The knowledge about the interaction between nanomaterials and biological media allows the development of more rational applications, as well understand and anticipate adverse and toxic effects resulting from this interaction. Endocytosis is an energy-dependent biological process responsible for internalization of nanoparticles, which depends on orchestrated events that require lipids and plasma membrane proteins functioning. Studies that aim to investigate in detail the endocytosis and intracellular trafficking of nanoparticles are essential for understanding cellular mechanisms, which in turn help to select its biomedical applications. In this context, this review aims to conceptualize the main routes of endocytosis used to study the internalization of nanomaterials in eukaryotic cells. In addition, we discuss some intracellular trafficking of nanomaterials to aid in studies of the cellular processing and development of new therapeutic tools.Os avanços recentes da nanotecnologia têm aumentado a utilização de nanomateriais e nanodispositivos para diagnose, terapias e outros fins tecnológicos. O conhecimento da interação entre nanomateriais e meios biológicos permite a descoberta de aplicações mais racionais, podendo ajudar a entender e antever seus efeitos adversos e citotóxicos. A endocitose é um processo biológico dependente de energia que está envolvida na internalização de nanopartículas pelas células, e depende de eventos orquestrados que requerem o funcionamento coordenado dos lipídios e proteínas da membrana plasmática. Estudos que visam investigar em detalhes a endocitose e o tráfego intracelular de nanopartículas são indispensáveis para compreensão de mecanismos celulares ainda inexplorados e permitem projetar novas funções, que consequentemente auxiliam na escolha de aplicações biomédicas da nanotecnologia. Nesse contexto, esta revisão visa conceituar as principais vias de endocitose utilizadas no estudo da internalização de nanomateriais em células eucarióticas. Além disso, alguns destinos intracelulares de nanomateriais serão discutidos para auxiliar nos estudos do processamento celular de nanopartículas e desenvolvimento de novas ferramentas terapêuticas.Acta Farmacêutica Portuguesa2015-03-01T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://actafarmaceuticaportuguesa.com/index.php/afp/article/view/54oai:ojs.actafarmaceuticaportuguesa.com:article/54Acta Farmacêutica Portuguesa; v. 3 n. 2 (2014); 149-1662182-3340reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://actafarmaceuticaportuguesa.com/index.php/afp/article/view/54https://actafarmaceuticaportuguesa.com/index.php/afp/article/view/54/89Ferreira, L. A. B.Radaic, A.Pugliese, G. O.Valentini, M. B.Oliveira, M. R.de Jesus, M. B.info:eu-repo/semantics/openAccess2022-09-05T12:29:46Zoai:ojs.actafarmaceuticaportuguesa.com:article/54Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T14:59:54.540096Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Endocytosis and intracellular trafficking of nanomaterials
Endocitose e tráfego intracelular de nanomateriais
title Endocytosis and intracellular trafficking of nanomaterials
spellingShingle Endocytosis and intracellular trafficking of nanomaterials
Ferreira, L. A. B.
endocytosis nanoparticle
intracellular trafficking
Endocitose
nanopartícula
tráfego intracelular
title_short Endocytosis and intracellular trafficking of nanomaterials
title_full Endocytosis and intracellular trafficking of nanomaterials
title_fullStr Endocytosis and intracellular trafficking of nanomaterials
title_full_unstemmed Endocytosis and intracellular trafficking of nanomaterials
title_sort Endocytosis and intracellular trafficking of nanomaterials
author Ferreira, L. A. B.
author_facet Ferreira, L. A. B.
Radaic, A.
Pugliese, G. O.
Valentini, M. B.
Oliveira, M. R.
de Jesus, M. B.
author_role author
author2 Radaic, A.
Pugliese, G. O.
Valentini, M. B.
Oliveira, M. R.
de Jesus, M. B.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, L. A. B.
Radaic, A.
Pugliese, G. O.
Valentini, M. B.
Oliveira, M. R.
de Jesus, M. B.
dc.subject.por.fl_str_mv endocytosis nanoparticle
intracellular trafficking
Endocitose
nanopartícula
tráfego intracelular
topic endocytosis nanoparticle
intracellular trafficking
Endocitose
nanopartícula
tráfego intracelular
description Recent advances in nanotechnology have increased the use of nanomaterials and nanodevices for diagnostic, therapeutic and other technological applications. The knowledge about the interaction between nanomaterials and biological media allows the development of more rational applications, as well understand and anticipate adverse and toxic effects resulting from this interaction. Endocytosis is an energy-dependent biological process responsible for internalization of nanoparticles, which depends on orchestrated events that require lipids and plasma membrane proteins functioning. Studies that aim to investigate in detail the endocytosis and intracellular trafficking of nanoparticles are essential for understanding cellular mechanisms, which in turn help to select its biomedical applications. In this context, this review aims to conceptualize the main routes of endocytosis used to study the internalization of nanomaterials in eukaryotic cells. In addition, we discuss some intracellular trafficking of nanomaterials to aid in studies of the cellular processing and development of new therapeutic tools.
publishDate 2015
dc.date.none.fl_str_mv 2015-03-01T00:00:00Z
dc.type.driver.fl_str_mv journal article
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://actafarmaceuticaportuguesa.com/index.php/afp/article/view/54
oai:ojs.actafarmaceuticaportuguesa.com:article/54
url https://actafarmaceuticaportuguesa.com/index.php/afp/article/view/54
identifier_str_mv oai:ojs.actafarmaceuticaportuguesa.com:article/54
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://actafarmaceuticaportuguesa.com/index.php/afp/article/view/54
https://actafarmaceuticaportuguesa.com/index.php/afp/article/view/54/89
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Acta Farmacêutica Portuguesa
publisher.none.fl_str_mv Acta Farmacêutica Portuguesa
dc.source.none.fl_str_mv Acta Farmacêutica Portuguesa; v. 3 n. 2 (2014); 149-166
2182-3340
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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