Drug resistance in tuberculosis - a reinfection model

Detalhes bibliográficos
Autor(a) principal: Rodrigues, P.
Data de Publicação: 2007
Outros Autores: Gomes, M. G. M., Rebelo, C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/48
Resumo: There is increasing recognition that reinfection is an important component of TB transmission. Moreover, it has been shown that partial immunity has significant epidemiological consequences, particularly in what concerns disease prevalence and effectiveness of control measures. We address the problem of drug resistance as a competition between two types of strains of Mycobacterium tuberculosis: those that are sensitive to anti-tuberculosis drugs and those that are resistant. Our objective is to characterise the role of reinfection in the transmission of drug-resistant tuberculosis. The long-term behaviour of our model reflects how reinfection modifies the conditions for coexistence of sensitive and resistant strains. This sets the scene for discussing how strain prevalence is affected by different control strategies. It is shown that intervention effectiveness is highly sensitive to the baseline epidemiological setting.
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spelling Drug resistance in tuberculosis - a reinfection modelreinfectiondrug resistancetuberculosiscontrol strategiescoexistencemathematical modelsmycobacterium-tuberculosisThere is increasing recognition that reinfection is an important component of TB transmission. Moreover, it has been shown that partial immunity has significant epidemiological consequences, particularly in what concerns disease prevalence and effectiveness of control measures. We address the problem of drug resistance as a competition between two types of strains of Mycobacterium tuberculosis: those that are sensitive to anti-tuberculosis drugs and those that are resistant. Our objective is to characterise the role of reinfection in the transmission of drug-resistant tuberculosis. The long-term behaviour of our model reflects how reinfection modifies the conditions for coexistence of sensitive and resistant strains. This sets the scene for discussing how strain prevalence is affected by different control strategies. It is shown that intervention effectiveness is highly sensitive to the baseline epidemiological setting.ARCARodrigues, P.Gomes, M. G. M.Rebelo, C.2009-10-08T14:41:58Z20072007-032009-10-08T14:41:59Z2007-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/48eng0040-5809info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:34:35Zoai:arca.igc.gulbenkian.pt:10400.7/48Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:32.817411Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Drug resistance in tuberculosis - a reinfection model
title Drug resistance in tuberculosis - a reinfection model
spellingShingle Drug resistance in tuberculosis - a reinfection model
Rodrigues, P.
reinfection
drug resistance
tuberculosis
control strategies
coexistence
mathematical models
mycobacterium-tuberculosis
title_short Drug resistance in tuberculosis - a reinfection model
title_full Drug resistance in tuberculosis - a reinfection model
title_fullStr Drug resistance in tuberculosis - a reinfection model
title_full_unstemmed Drug resistance in tuberculosis - a reinfection model
title_sort Drug resistance in tuberculosis - a reinfection model
author Rodrigues, P.
author_facet Rodrigues, P.
Gomes, M. G. M.
Rebelo, C.
author_role author
author2 Gomes, M. G. M.
Rebelo, C.
author2_role author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Rodrigues, P.
Gomes, M. G. M.
Rebelo, C.
dc.subject.por.fl_str_mv reinfection
drug resistance
tuberculosis
control strategies
coexistence
mathematical models
mycobacterium-tuberculosis
topic reinfection
drug resistance
tuberculosis
control strategies
coexistence
mathematical models
mycobacterium-tuberculosis
description There is increasing recognition that reinfection is an important component of TB transmission. Moreover, it has been shown that partial immunity has significant epidemiological consequences, particularly in what concerns disease prevalence and effectiveness of control measures. We address the problem of drug resistance as a competition between two types of strains of Mycobacterium tuberculosis: those that are sensitive to anti-tuberculosis drugs and those that are resistant. Our objective is to characterise the role of reinfection in the transmission of drug-resistant tuberculosis. The long-term behaviour of our model reflects how reinfection modifies the conditions for coexistence of sensitive and resistant strains. This sets the scene for discussing how strain prevalence is affected by different control strategies. It is shown that intervention effectiveness is highly sensitive to the baseline epidemiological setting.
publishDate 2007
dc.date.none.fl_str_mv 2007
2007-03
2007-03-01T00:00:00Z
2009-10-08T14:41:58Z
2009-10-08T14:41:59Z
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