Genetic determinants and absence of breast cancer in Xavante Indians in Sangradouro Reserve, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/148758 |
Resumo: | Genetic compositions of distinct human populations are different. How genomic variants influence many common and rare genetic diseases is always of great medical and anthropological interest, and understanding of genetic architectures of population groups in relation to diseases can advance our knowledge of medicine. Here, we have studied the genomic architecture of a group of Xavante Indians, an indigenous population in Brazil, and compared them with normal populations from the 1000 Genomes Projects. Principal component analysis (PCA) indicates that the Xavante Indians are genetically distinctive when compared to other ethnic groups. No incidence of breast cancer cases has ever been reported in the population, and polygenic risk analysis indicates extremely low breast cancer risk in this population when compared with germline TCGA (The Cancer Genome Atlas) breast cancer normal control samples. Low germinal mutation burden among this population is also observed. Our findings will help to deepen the understanding of breast cancer and might also provide new approaches to study the disease. |
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Genetic determinants and absence of breast cancer in Xavante Indians in Sangradouro Reserve, BrazilAnthropologyAsian PeopleBrazilBreast NeoplasmsEthnicityFemaleHumansIndiansSouth AmericanAmerican IndianSDG 3 - Good Health and Well-beingGenetic compositions of distinct human populations are different. How genomic variants influence many common and rare genetic diseases is always of great medical and anthropological interest, and understanding of genetic architectures of population groups in relation to diseases can advance our knowledge of medicine. Here, we have studied the genomic architecture of a group of Xavante Indians, an indigenous population in Brazil, and compared them with normal populations from the 1000 Genomes Projects. Principal component analysis (PCA) indicates that the Xavante Indians are genetically distinctive when compared to other ethnic groups. No incidence of breast cancer cases has ever been reported in the population, and polygenic risk analysis indicates extremely low breast cancer risk in this population when compared with germline TCGA (The Cancer Genome Atlas) breast cancer normal control samples. Low germinal mutation burden among this population is also observed. Our findings will help to deepen the understanding of breast cancer and might also provide new approaches to study the disease.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centre for Toxicogenomics and Human Health (ToxOmics)RUNZhou, YanRusso, JoseRueff, JoséPires, Marcelo A. M.De castro, Guilherme Bezerra2023-02-06T22:18:30Z2023-01-262023-01-26T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/148758eng2045-2322PURE: 51803918https://doi.org/10.1038/s41598-023-28461-yinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-18T01:42:50Zoai:run.unl.pt:10362/148758Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:28.652014Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Genetic determinants and absence of breast cancer in Xavante Indians in Sangradouro Reserve, Brazil |
title |
Genetic determinants and absence of breast cancer in Xavante Indians in Sangradouro Reserve, Brazil |
spellingShingle |
Genetic determinants and absence of breast cancer in Xavante Indians in Sangradouro Reserve, Brazil Zhou, Yan Anthropology Asian People Brazil Breast Neoplasms Ethnicity Female Humans Indians South American American Indian SDG 3 - Good Health and Well-being |
title_short |
Genetic determinants and absence of breast cancer in Xavante Indians in Sangradouro Reserve, Brazil |
title_full |
Genetic determinants and absence of breast cancer in Xavante Indians in Sangradouro Reserve, Brazil |
title_fullStr |
Genetic determinants and absence of breast cancer in Xavante Indians in Sangradouro Reserve, Brazil |
title_full_unstemmed |
Genetic determinants and absence of breast cancer in Xavante Indians in Sangradouro Reserve, Brazil |
title_sort |
Genetic determinants and absence of breast cancer in Xavante Indians in Sangradouro Reserve, Brazil |
author |
Zhou, Yan |
author_facet |
Zhou, Yan Russo, Jose Rueff, José Pires, Marcelo A. M. De castro, Guilherme Bezerra |
author_role |
author |
author2 |
Russo, Jose Rueff, José Pires, Marcelo A. M. De castro, Guilherme Bezerra |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centre for Toxicogenomics and Human Health (ToxOmics) RUN |
dc.contributor.author.fl_str_mv |
Zhou, Yan Russo, Jose Rueff, José Pires, Marcelo A. M. De castro, Guilherme Bezerra |
dc.subject.por.fl_str_mv |
Anthropology Asian People Brazil Breast Neoplasms Ethnicity Female Humans Indians South American American Indian SDG 3 - Good Health and Well-being |
topic |
Anthropology Asian People Brazil Breast Neoplasms Ethnicity Female Humans Indians South American American Indian SDG 3 - Good Health and Well-being |
description |
Genetic compositions of distinct human populations are different. How genomic variants influence many common and rare genetic diseases is always of great medical and anthropological interest, and understanding of genetic architectures of population groups in relation to diseases can advance our knowledge of medicine. Here, we have studied the genomic architecture of a group of Xavante Indians, an indigenous population in Brazil, and compared them with normal populations from the 1000 Genomes Projects. Principal component analysis (PCA) indicates that the Xavante Indians are genetically distinctive when compared to other ethnic groups. No incidence of breast cancer cases has ever been reported in the population, and polygenic risk analysis indicates extremely low breast cancer risk in this population when compared with germline TCGA (The Cancer Genome Atlas) breast cancer normal control samples. Low germinal mutation burden among this population is also observed. Our findings will help to deepen the understanding of breast cancer and might also provide new approaches to study the disease. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-02-06T22:18:30Z 2023-01-26 2023-01-26T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/148758 |
url |
http://hdl.handle.net/10362/148758 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2045-2322 PURE: 51803918 https://doi.org/10.1038/s41598-023-28461-y |
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info:eu-repo/semantics/openAccess |
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openAccess |
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