Zinc Deficiency Interacts with Intestinal/Urogenital Parasites in the Pathway to Anemia in Preschool Children, Bengo-Angola

Detalhes bibliográficos
Autor(a) principal: Fançony, Cláudia
Data de Publicação: 2022
Outros Autores: Soares, Ânia, Lavinha, João, Brito, Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8408
Resumo: This article belongs to the Section Micronutrients and Human Health.
id RCAP_d4fb6c2572ed9314b9aaee1fe4269de3
oai_identifier_str oai:repositorio.insa.pt:10400.18/8408
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Zinc Deficiency Interacts with Intestinal/Urogenital Parasites in the Pathway to Anemia in Preschool Children, Bengo-AngolaAnemiaInfectionsInflammationZinc DeficiencyAngolaDoenças GenéticasZincoInfeçãoInflamaçãoThis article belongs to the Section Micronutrients and Human Health.In host organisms with normal micronutrient status, nutritional immunity is a strongly regulated response aiming at decreasing the progression and severity of infections. Zinc deficiency may disturb this balance, impairing immune responses to infections, which may indirectly increase infection-related anemia. Since zinc deficiency may associate directly with anemia, the role of infections is often overlooked. Herein, we investigated the participation of infections (or inflammation) in the causal pathway between zinc deficiency and anemia. This transversal study, conducted in 2015 in Bengo-Angola, enrolled 852 under-3-year-old children. Logistic regression models were used to investigate interaction and mediation effects, and significance was confirmed by the Sobel test. In sum, 6.8% of children had zinc deficiency, 45.9% had anemia, and 15.6% had at least one intestinal/urogenital parasite. Furthermore, we found (1) no evidence that inflammation mediates or interacts with zinc deficiency to cause anemia, and (2) zinc deficiency interacts with infections, significantly increasing the odds of anemia (OR: 13.26, p = 0.022). This interaction was stronger among children with iron deficiency anemia (OR: 46.66, p = 0.003). Our results suggest that zinc deficiency may impair the immune response to infections and/or that intestinal parasites could have developed mechanisms to avoid zinc-limited environments. Further studies are needed to corroborate these suggestions.This study had financial support from the Fundação Calouste Gulbenkian and Camões IP, Instituto da Cooperação e da Língua from PortugalMDPIRepositório Científico do Instituto Nacional de SaúdeFançony, CláudiaSoares, ÂniaLavinha, JoãoBrito, Miguel2023-01-09T14:59:39Z2022-03-272022-03-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8408engNutrients. 2022 Mar 27;14(7):1392. doi: 10.3390/nu14071392.2072-6643doi.org/10.3390/nu14071392info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:34Zoai:repositorio.insa.pt:10400.18/8408Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:43:05.394953Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Zinc Deficiency Interacts with Intestinal/Urogenital Parasites in the Pathway to Anemia in Preschool Children, Bengo-Angola
title Zinc Deficiency Interacts with Intestinal/Urogenital Parasites in the Pathway to Anemia in Preschool Children, Bengo-Angola
spellingShingle Zinc Deficiency Interacts with Intestinal/Urogenital Parasites in the Pathway to Anemia in Preschool Children, Bengo-Angola
Fançony, Cláudia
Anemia
Infections
Inflammation
Zinc Deficiency
Angola
Doenças Genéticas
Zinco
Infeção
Inflamação
title_short Zinc Deficiency Interacts with Intestinal/Urogenital Parasites in the Pathway to Anemia in Preschool Children, Bengo-Angola
title_full Zinc Deficiency Interacts with Intestinal/Urogenital Parasites in the Pathway to Anemia in Preschool Children, Bengo-Angola
title_fullStr Zinc Deficiency Interacts with Intestinal/Urogenital Parasites in the Pathway to Anemia in Preschool Children, Bengo-Angola
title_full_unstemmed Zinc Deficiency Interacts with Intestinal/Urogenital Parasites in the Pathway to Anemia in Preschool Children, Bengo-Angola
title_sort Zinc Deficiency Interacts with Intestinal/Urogenital Parasites in the Pathway to Anemia in Preschool Children, Bengo-Angola
author Fançony, Cláudia
author_facet Fançony, Cláudia
Soares, Ânia
Lavinha, João
Brito, Miguel
author_role author
author2 Soares, Ânia
Lavinha, João
Brito, Miguel
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Fançony, Cláudia
Soares, Ânia
Lavinha, João
Brito, Miguel
dc.subject.por.fl_str_mv Anemia
Infections
Inflammation
Zinc Deficiency
Angola
Doenças Genéticas
Zinco
Infeção
Inflamação
topic Anemia
Infections
Inflammation
Zinc Deficiency
Angola
Doenças Genéticas
Zinco
Infeção
Inflamação
description This article belongs to the Section Micronutrients and Human Health.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-27
2022-03-27T00:00:00Z
2023-01-09T14:59:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8408
url http://hdl.handle.net/10400.18/8408
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nutrients. 2022 Mar 27;14(7):1392. doi: 10.3390/nu14071392.
2072-6643
doi.org/10.3390/nu14071392
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132176726360064

Registros relacionados