Editorial: Advanced (gene and cell) therapies for central nervous system applications
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/19321 |
Resumo: | Advanced therapies as defined by the European Medicines Agency (EMA) comprises strategies involving gene therapy, cell therapy, and tissue engineering. Overall, these strategies offer a wide range of possibilities to treat and cure diseases, including those affecting the central nervous system (CNS). In this line, Advanced (Gene and Cell) Therapies for Central Nervous System Applications Research Topic was intended to provide a platform for researchers to publish their findings, contributing to the continuous advance of this research area. Nine papers were accepted and published in this Research Topic, from which four described original research data, two papers were reviews and two mini reviews, and one paper focused on hypothesis and theory. In the paper Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques (Arotcarena et al.), presented new data on the biodistribution and CNS transduction efficiencies after lumbar intrathecal bolus delivery of identical doses of either AAV-PH.B:CAG-EGFP or AAV-PHP.eB:CAG-EGFP in rhesus macaque monkeys. |
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Editorial: Advanced (gene and cell) therapies for central nervous system applicationsGene augmentationGene silencinggene editingViral and non-viral vectors for gene therapyCell therapycell replacement and neuroprotectionBrain experimental models-brain organoidsBrain delivery and brain diseasesAdvanced therapies as defined by the European Medicines Agency (EMA) comprises strategies involving gene therapy, cell therapy, and tissue engineering. Overall, these strategies offer a wide range of possibilities to treat and cure diseases, including those affecting the central nervous system (CNS). In this line, Advanced (Gene and Cell) Therapies for Central Nervous System Applications Research Topic was intended to provide a platform for researchers to publish their findings, contributing to the continuous advance of this research area. Nine papers were accepted and published in this Research Topic, from which four described original research data, two papers were reviews and two mini reviews, and one paper focused on hypothesis and theory. In the paper Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques (Arotcarena et al.), presented new data on the biodistribution and CNS transduction efficiencies after lumbar intrathecal bolus delivery of identical doses of either AAV-PH.B:CAG-EGFP or AAV-PHP.eB:CAG-EGFP in rhesus macaque monkeys.Frontiers MediaSapientiaMendonça, LilianaWebster, ChristopherBoltze, JohannesNóbrega, Clévio2023-03-27T10:02:16Z2023-022023-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/19321eng1662-509910.3389/fnmol.2023.1140949info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:31:46Zoai:sapientia.ualg.pt:10400.1/19321Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:08:58.587960Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Editorial: Advanced (gene and cell) therapies for central nervous system applications |
title |
Editorial: Advanced (gene and cell) therapies for central nervous system applications |
spellingShingle |
Editorial: Advanced (gene and cell) therapies for central nervous system applications Mendonça, Liliana Gene augmentation Gene silencinggene editing Viral and non-viral vectors for gene therapy Cell therapycell replacement and neuroprotection Brain experimental models-brain organoids Brain delivery and brain diseases |
title_short |
Editorial: Advanced (gene and cell) therapies for central nervous system applications |
title_full |
Editorial: Advanced (gene and cell) therapies for central nervous system applications |
title_fullStr |
Editorial: Advanced (gene and cell) therapies for central nervous system applications |
title_full_unstemmed |
Editorial: Advanced (gene and cell) therapies for central nervous system applications |
title_sort |
Editorial: Advanced (gene and cell) therapies for central nervous system applications |
author |
Mendonça, Liliana |
author_facet |
Mendonça, Liliana Webster, Christopher Boltze, Johannes Nóbrega, Clévio |
author_role |
author |
author2 |
Webster, Christopher Boltze, Johannes Nóbrega, Clévio |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Mendonça, Liliana Webster, Christopher Boltze, Johannes Nóbrega, Clévio |
dc.subject.por.fl_str_mv |
Gene augmentation Gene silencinggene editing Viral and non-viral vectors for gene therapy Cell therapycell replacement and neuroprotection Brain experimental models-brain organoids Brain delivery and brain diseases |
topic |
Gene augmentation Gene silencinggene editing Viral and non-viral vectors for gene therapy Cell therapycell replacement and neuroprotection Brain experimental models-brain organoids Brain delivery and brain diseases |
description |
Advanced therapies as defined by the European Medicines Agency (EMA) comprises strategies involving gene therapy, cell therapy, and tissue engineering. Overall, these strategies offer a wide range of possibilities to treat and cure diseases, including those affecting the central nervous system (CNS). In this line, Advanced (Gene and Cell) Therapies for Central Nervous System Applications Research Topic was intended to provide a platform for researchers to publish their findings, contributing to the continuous advance of this research area. Nine papers were accepted and published in this Research Topic, from which four described original research data, two papers were reviews and two mini reviews, and one paper focused on hypothesis and theory. In the paper Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques (Arotcarena et al.), presented new data on the biodistribution and CNS transduction efficiencies after lumbar intrathecal bolus delivery of identical doses of either AAV-PH.B:CAG-EGFP or AAV-PHP.eB:CAG-EGFP in rhesus macaque monkeys. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-27T10:02:16Z 2023-02 2023-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/19321 |
url |
http://hdl.handle.net/10400.1/19321 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1662-5099 10.3389/fnmol.2023.1140949 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133336275255296 |