DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death

Bonassi, Stefano; Ceppi, Marcello; Møller, Peter; Azqueta, Amaya; Milić, Mirta; Neri, Monica; Brunborg, Gunnar; Godschalk, Roger; Koppen, Gudrun; Langie, Sabine A.S.; Teixeira, João Paulo; Bruzzone, Marco; Da Silva, Juliana; Benedetti, Danieli; Cavallo, Delia; Ursini, Cinzia Lucia; Giovannelli, Lisa; Moretti, Silvia; Riso, Patrizia; Del Bo’, Cristian; Russo, Patrizia; Dobrzyńska, Malgorzata; Goroshinskaya, Irina A.; Surikova, Ekaterina I.; Staruchova, Marta; Barančokova, Magdalena; Volkovova, Katarina; Kažimirova, Alena; Smolkova, Bozena; Laffon, Blanca; Valdiglesias, Vanessa; Pastor, Susana; Marcos, Ricard; Hernández, Alba; Gajski, Goran; Spremo-Potparević, Biljana; Živković, Lada; Boutet-Robinet, Elisa; Perdry, Hervé; Lebailly, Pierre; Perez, Carlos L.; Basaran, Nursen; Nemeth, Zsuzsanna; Safar, Anna; Dusinska, Maria; Collins, Andrew; Anderson, Diana; Andrade, Vanessa; Pereira, Cristiana Costa; Costa, Solange; Gutzkow, Kristine B.; Ladeira, Carina; Moretti, Massimo; Costa, Carla; Orlow, Irene; Rojas, Emilio; Pourrut, Bertrand; Kruszewski, Marcin; Knasmueller, Siegfried; Shaposhnikov, Sergey; Žegura, Bojana; Stopper, Helga

DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death

Detalhes bibliográficos
Autor(a) principal:	Bonassi, Stefano
Data de Publicação:	2021
Outros Autores:	Ceppi, Marcello, Møller, Peter, Azqueta, Amaya, Milić, Mirta, Neri, Monica, Brunborg, Gunnar, Godschalk, Roger, Koppen, Gudrun, Langie, Sabine A.S., Teixeira, João Paulo, Bruzzone, Marco, Da Silva, Juliana, Benedetti, Danieli, Cavallo, Delia, Ursini, Cinzia Lucia, Giovannelli, Lisa, Moretti, Silvia, Riso, Patrizia, Del Bo’, Cristian, Russo, Patrizia, Dobrzyńska, Malgorzata, Goroshinskaya, Irina A., Surikova, Ekaterina I., Staruchova, Marta, Barančokova, Magdalena, Volkovova, Katarina, Kažimirova, Alena, Smolkova, Bozena, Laffon, Blanca, Valdiglesias, Vanessa, Pastor, Susana, Marcos, Ricard, Hernández, Alba, Gajski, Goran, Spremo-Potparević, Biljana, Živković, Lada, Boutet-Robinet, Elisa, Perdry, Hervé, Lebailly, Pierre, Perez, Carlos L., Basaran, Nursen, Nemeth, Zsuzsanna, Safar, Anna, Dusinska, Maria, Collins, Andrew, Anderson, Diana, Andrade, Vanessa, Pereira, Cristiana Costa, Costa, Solange, Gutzkow, Kristine B., Ladeira, Carina, Moretti, Massimo, Costa, Carla, Orlow, Irene, Rojas, Emilio, Pourrut, Bertrand, Kruszewski, Marcin, Knasmueller, Siegfried, Shaposhnikov, Sergey, Žegura, Bojana, Stopper, Helga
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo:	http://hdl.handle.net/10400.18/8225
Resumo:	Collaborators hCOMET project: Diana Anderson, Vanessa Andrade, Cristiana Costa Pereira, Solange Costa, Kristine B Gutzkow, Carina Ladeira, Massimo Moretti, Carla Costa, Irene Orlow, Emilio Rojas, Bertrand Pourrut, Marcin Kruszewski, Siegfried Knasmueller, Sergey Shaposhnikov, Bojana Žegura, Helga Stopper.

Metadados do item

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network_name_str	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str	7160
spelling	DNA damage in circulating leukocytes measured with the comet assay may predict the risk of deathCell-Free Nucleic AcidsComet AssayDNA DamageLeukocytesNeoplasmsGenotoxicidade AmbientalCollaborators hCOMET project: Diana Anderson, Vanessa Andrade, Cristiana Costa Pereira, Solange Costa, Kristine B Gutzkow, Carina Ladeira, Massimo Moretti, Carla Costa, Irene Orlow, Emilio Rojas, Bertrand Pourrut, Marcin Kruszewski, Siegfried Knasmueller, Sergey Shaposhnikov, Bojana Žegura, Helga Stopper.Erratum in - Author Correction. Sci Rep. 2021 Sep 20;11(1):19043. doi: 10.1038/s41598-021-98620-6.The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2,403 healthy individuals (25,978 person-years) screened in 16 laboratories using the comet assay between 1996 and 2016 was followed-up. Kaplan-Meier analysis indicated a worse overall survival in the medium and high tertile of DNA damage (p < 0.001). The effect of DNA damage on survival was modelled according to Cox proportional hazard regression model. The adjusted hazard ratio (HR) was 1.42 (1.06-1.90) for overall mortality, and 1.94 (1.04-3.59) for diseases of the circulatory system in subjects with the highest tertile of DNA damage. The findings of this study provide epidemiological evidence encouraging the implementation of the comet assay in preventive strategies for non-communicable diseases.Nature ResearchRepositório Científico do Instituto Nacional de SaúdeBonassi, StefanoCeppi, MarcelloMøller, PeterAzqueta, AmayaMilić, MirtaNeri, MonicaBrunborg, GunnarGodschalk, RogerKoppen, GudrunLangie, Sabine A.S.Teixeira, João PauloBruzzone, MarcoDa Silva, JulianaBenedetti, DanieliCavallo, DeliaUrsini, Cinzia LuciaGiovannelli, LisaMoretti, SilviaRiso, PatriziaDel Bo’, CristianRusso, PatriziaDobrzyńska, MalgorzataGoroshinskaya, Irina A.Surikova, Ekaterina I.Staruchova, MartaBarančokova, MagdalenaVolkovova, KatarinaKažimirova, AlenaSmolkova, BozenaLaffon, BlancaValdiglesias, VanessaPastor, SusanaMarcos, RicardHernández, AlbaGajski, GoranSpremo-Potparević, BiljanaŽivković, LadaBoutet-Robinet, ElisaPerdry, HervéLebailly, PierrePerez, Carlos L.Basaran, NursenNemeth, ZsuzsannaSafar, AnnaDusinska, MariaCollins, AndrewAnderson, DianaAndrade, VanessaPereira, Cristiana CostaCosta, SolangeGutzkow, Kristine B.Ladeira, CarinaMoretti, MassimoCosta, CarlaOrlow, IreneRojas, EmilioPourrut, BertrandKruszewski, MarcinKnasmueller, SiegfriedShaposhnikov, SergeyŽegura, BojanaStopper, Helga2022-07-11T16:20:37Z2021-08-182021-08-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.18/8225engSci Rep. 2021 Aug 18;11(1):16793. doi: 10.1038/s41598-021-95976-72045-232210.1038/s41598-021-95976-7info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:25Zoai:repositorio.insa.pt:10400.18/8225Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:48.712132Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv	DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
title	DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
spellingShingle	DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death Bonassi, Stefano Cell-Free Nucleic Acids Comet Assay DNA Damage Leukocytes Neoplasms Genotoxicidade Ambiental
title_short	DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
title_full	DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
title_fullStr	DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
title_full_unstemmed	DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
title_sort	DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
author	Bonassi, Stefano
author_facet	Bonassi, Stefano Ceppi, Marcello Møller, Peter Azqueta, Amaya Milić, Mirta Neri, Monica Brunborg, Gunnar Godschalk, Roger Koppen, Gudrun Langie, Sabine A.S. Teixeira, João Paulo Bruzzone, Marco Da Silva, Juliana Benedetti, Danieli Cavallo, Delia Ursini, Cinzia Lucia Giovannelli, Lisa Moretti, Silvia Riso, Patrizia Del Bo’, Cristian Russo, Patrizia Dobrzyńska, Malgorzata Goroshinskaya, Irina A. Surikova, Ekaterina I. Staruchova, Marta Barančokova, Magdalena Volkovova, Katarina Kažimirova, Alena Smolkova, Bozena Laffon, Blanca Valdiglesias, Vanessa Pastor, Susana Marcos, Ricard Hernández, Alba Gajski, Goran Spremo-Potparević, Biljana Živković, Lada Boutet-Robinet, Elisa Perdry, Hervé Lebailly, Pierre Perez, Carlos L. Basaran, Nursen Nemeth, Zsuzsanna Safar, Anna Dusinska, Maria Collins, Andrew Anderson, Diana Andrade, Vanessa Pereira, Cristiana Costa Costa, Solange Gutzkow, Kristine B. Ladeira, Carina Moretti, Massimo Costa, Carla Orlow, Irene Rojas, Emilio Pourrut, Bertrand Kruszewski, Marcin Knasmueller, Siegfried Shaposhnikov, Sergey Žegura, Bojana Stopper, Helga
author_role	author
author2	Ceppi, Marcello Møller, Peter Azqueta, Amaya Milić, Mirta Neri, Monica Brunborg, Gunnar Godschalk, Roger Koppen, Gudrun Langie, Sabine A.S. Teixeira, João Paulo Bruzzone, Marco Da Silva, Juliana Benedetti, Danieli Cavallo, Delia Ursini, Cinzia Lucia Giovannelli, Lisa Moretti, Silvia Riso, Patrizia Del Bo’, Cristian Russo, Patrizia Dobrzyńska, Malgorzata Goroshinskaya, Irina A. Surikova, Ekaterina I. Staruchova, Marta Barančokova, Magdalena Volkovova, Katarina Kažimirova, Alena Smolkova, Bozena Laffon, Blanca Valdiglesias, Vanessa Pastor, Susana Marcos, Ricard Hernández, Alba Gajski, Goran Spremo-Potparević, Biljana Živković, Lada Boutet-Robinet, Elisa Perdry, Hervé Lebailly, Pierre Perez, Carlos L. Basaran, Nursen Nemeth, Zsuzsanna Safar, Anna Dusinska, Maria Collins, Andrew Anderson, Diana Andrade, Vanessa Pereira, Cristiana Costa Costa, Solange Gutzkow, Kristine B. Ladeira, Carina Moretti, Massimo Costa, Carla Orlow, Irene Rojas, Emilio Pourrut, Bertrand Kruszewski, Marcin Knasmueller, Siegfried Shaposhnikov, Sergey Žegura, Bojana Stopper, Helga
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv	Bonassi, Stefano Ceppi, Marcello Møller, Peter Azqueta, Amaya Milić, Mirta Neri, Monica Brunborg, Gunnar Godschalk, Roger Koppen, Gudrun Langie, Sabine A.S. Teixeira, João Paulo Bruzzone, Marco Da Silva, Juliana Benedetti, Danieli Cavallo, Delia Ursini, Cinzia Lucia Giovannelli, Lisa Moretti, Silvia Riso, Patrizia Del Bo’, Cristian Russo, Patrizia Dobrzyńska, Malgorzata Goroshinskaya, Irina A. Surikova, Ekaterina I. Staruchova, Marta Barančokova, Magdalena Volkovova, Katarina Kažimirova, Alena Smolkova, Bozena Laffon, Blanca Valdiglesias, Vanessa Pastor, Susana Marcos, Ricard Hernández, Alba Gajski, Goran Spremo-Potparević, Biljana Živković, Lada Boutet-Robinet, Elisa Perdry, Hervé Lebailly, Pierre Perez, Carlos L. Basaran, Nursen Nemeth, Zsuzsanna Safar, Anna Dusinska, Maria Collins, Andrew Anderson, Diana Andrade, Vanessa Pereira, Cristiana Costa Costa, Solange Gutzkow, Kristine B. Ladeira, Carina Moretti, Massimo Costa, Carla Orlow, Irene Rojas, Emilio Pourrut, Bertrand Kruszewski, Marcin Knasmueller, Siegfried Shaposhnikov, Sergey Žegura, Bojana Stopper, Helga
dc.subject.por.fl_str_mv	Cell-Free Nucleic Acids Comet Assay DNA Damage Leukocytes Neoplasms Genotoxicidade Ambiental
topic	Cell-Free Nucleic Acids Comet Assay DNA Damage Leukocytes Neoplasms Genotoxicidade Ambiental
description	Collaborators hCOMET project: Diana Anderson, Vanessa Andrade, Cristiana Costa Pereira, Solange Costa, Kristine B Gutzkow, Carina Ladeira, Massimo Moretti, Carla Costa, Irene Orlow, Emilio Rojas, Bertrand Pourrut, Marcin Kruszewski, Siegfried Knasmueller, Sergey Shaposhnikov, Bojana Žegura, Helga Stopper.
publishDate	2021
dc.date.none.fl_str_mv	2021-08-18 2021-08-18T00:00:00Z 2022-07-11T16:20:37Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://hdl.handle.net/10400.18/8225
url	http://hdl.handle.net/10400.18/8225
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	Sci Rep. 2021 Aug 18;11(1):16793. doi: 10.1038/s41598-021-95976-7 2045-2322 10.1038/s41598-021-95976-7
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	Nature Research
publisher.none.fl_str_mv	Nature Research
dc.source.none.fl_str_mv	reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP
instname_str	Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str	RCAAP
institution	RCAAP
reponame_str	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death

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