The state of the art in immuno-allergology: histamine releasing factors (HRF).

Detalhes bibliográficos
Autor(a) principal: Carlos, A G
Data de Publicação: 1989
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4619
Resumo: The present concepts on histamine releasing factors are discussed, their cellular origins, their effect on the target cells and its importance in asthma immunopathology. Personal results on the production of HRF by alveolar macrophages stimulated by allergen and its action on non atopic basophils are presented. Alveolar macrophages from atopic asthmatics release HRF in presence of allergen. Macrophage from non atopic do not. HRF has been tested in a Human Basophil Degranulation Test (HBDT) preparation, a significant degranulation induced by HRF from atopic patient being only observed when atopic basophils are used in HBDT. These results confirm that allergen could induce HRF production from alveolar macrophages and that this HRF could degranulate basophils in atopic and induce mediators release.
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spelling The state of the art in immuno-allergology: histamine releasing factors (HRF).State of the art em imuno-alergologia: os factores libertadores da histamina (HRF).The present concepts on histamine releasing factors are discussed, their cellular origins, their effect on the target cells and its importance in asthma immunopathology. Personal results on the production of HRF by alveolar macrophages stimulated by allergen and its action on non atopic basophils are presented. Alveolar macrophages from atopic asthmatics release HRF in presence of allergen. Macrophage from non atopic do not. HRF has been tested in a Human Basophil Degranulation Test (HBDT) preparation, a significant degranulation induced by HRF from atopic patient being only observed when atopic basophils are used in HBDT. These results confirm that allergen could induce HRF production from alveolar macrophages and that this HRF could degranulate basophils in atopic and induce mediators release.The present concepts on histamine releasing factors are discussed, their cellular origins, their effect on the target cells and its importance in asthma immunopathology. Personal results on the production of HRF by alveolar macrophages stimulated by allergen and its action on non atopic basophils are presented. Alveolar macrophages from atopic asthmatics release HRF in presence of allergen. Macrophage from non atopic do not. HRF has been tested in a Human Basophil Degranulation Test (HBDT) preparation, a significant degranulation induced by HRF from atopic patient being only observed when atopic basophils are used in HBDT. These results confirm that allergen could induce HRF production from alveolar macrophages and that this HRF could degranulate basophils in atopic and induce mediators release.Ordem dos Médicos1989-12-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4619oai:ojs.www.actamedicaportuguesa.com:article/4619Acta Médica Portuguesa; Vol. 2 (1989): Suplemento 2; S34-8Acta Médica Portuguesa; Vol. 2 (1989): Suplemento 2; S34-81646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4619https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4619/3631Carlos, A Ginfo:eu-repo/semantics/openAccess2022-12-20T11:03:55Zoai:ojs.www.actamedicaportuguesa.com:article/4619Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:18:56.549988Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The state of the art in immuno-allergology: histamine releasing factors (HRF).
State of the art em imuno-alergologia: os factores libertadores da histamina (HRF).
title The state of the art in immuno-allergology: histamine releasing factors (HRF).
spellingShingle The state of the art in immuno-allergology: histamine releasing factors (HRF).
Carlos, A G
title_short The state of the art in immuno-allergology: histamine releasing factors (HRF).
title_full The state of the art in immuno-allergology: histamine releasing factors (HRF).
title_fullStr The state of the art in immuno-allergology: histamine releasing factors (HRF).
title_full_unstemmed The state of the art in immuno-allergology: histamine releasing factors (HRF).
title_sort The state of the art in immuno-allergology: histamine releasing factors (HRF).
author Carlos, A G
author_facet Carlos, A G
author_role author
dc.contributor.author.fl_str_mv Carlos, A G
description The present concepts on histamine releasing factors are discussed, their cellular origins, their effect on the target cells and its importance in asthma immunopathology. Personal results on the production of HRF by alveolar macrophages stimulated by allergen and its action on non atopic basophils are presented. Alveolar macrophages from atopic asthmatics release HRF in presence of allergen. Macrophage from non atopic do not. HRF has been tested in a Human Basophil Degranulation Test (HBDT) preparation, a significant degranulation induced by HRF from atopic patient being only observed when atopic basophils are used in HBDT. These results confirm that allergen could induce HRF production from alveolar macrophages and that this HRF could degranulate basophils in atopic and induce mediators release.
publishDate 1989
dc.date.none.fl_str_mv 1989-12-31
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4619
oai:ojs.www.actamedicaportuguesa.com:article/4619
url https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4619
identifier_str_mv oai:ojs.www.actamedicaportuguesa.com:article/4619
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4619
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4619/3631
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 2 (1989): Suplemento 2; S34-8
Acta Médica Portuguesa; Vol. 2 (1989): Suplemento 2; S34-8
1646-0758
0870-399X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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