Preconcentration and sensitive determination of the anti-inflammatory drug diclofenac on a paper-based electroanalytical platform

Detalhes bibliográficos
Autor(a) principal: Costa-Rama, E.
Data de Publicação: 2019
Outros Autores: Nouws, H., Delerue-Matos, Cristina, Blanco-López, M.C., Fernández-Abedul, M.T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/16091
Resumo: This work describes the development of a paper-based platform for highly sensitive detection of diclofenac. The quantification of this anti-inflammatory drug is of importance in clinical (e.g. quality and therapeutic control) and environmental (e.g. emerging contaminant determination) areas. The easy-to-handle platform here described consists of a carbon-ink paper-based working electrode and two metallic wires, provided by a gold-plated standard connector, as reference and counter electrodes. The porous paper matrix enables the preconcentration of the sample, decoupling sample and detection solutions. Thus, relatively large sample volumes can be used, which significantly improves the sensitivity of the method. A wide dynamic range of four orders of magnitude, between 0.10 and 100 μM, was obtained for diclofenac determination. Due to the predominance of adsorption at the lowest concentrations, there were two linear concentration ranges: one comprised between 0.10 and 5.0 μM (with a slope of 0.85 μA μM-1) and the other between 5.0 and 100 μM (with a slope of 0.48 μA μM-1). A limit of detection of 70 nM was achieved with this simple device that provided accurate results with an RSD of ca. 5%. The platform was applied for diclofenac quantification in spiked tap water samples. The versatility of this design enabled the fabrication of a multiplexed platform containing eight electrochemical cells that work independently. The low cost, small size and simplicity of the device allow on-site analysis, which is very useful for environmental monitoring.
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spelling Preconcentration and sensitive determination of the anti-inflammatory drug diclofenac on a paper-based electroanalytical platformPaper-based electroanalysisElectroanalytical platformsMultiplexingLow-cost analysisAnti-inflammatory drugsDiclofenacThis work describes the development of a paper-based platform for highly sensitive detection of diclofenac. The quantification of this anti-inflammatory drug is of importance in clinical (e.g. quality and therapeutic control) and environmental (e.g. emerging contaminant determination) areas. The easy-to-handle platform here described consists of a carbon-ink paper-based working electrode and two metallic wires, provided by a gold-plated standard connector, as reference and counter electrodes. The porous paper matrix enables the preconcentration of the sample, decoupling sample and detection solutions. Thus, relatively large sample volumes can be used, which significantly improves the sensitivity of the method. A wide dynamic range of four orders of magnitude, between 0.10 and 100 μM, was obtained for diclofenac determination. Due to the predominance of adsorption at the lowest concentrations, there were two linear concentration ranges: one comprised between 0.10 and 5.0 μM (with a slope of 0.85 μA μM-1) and the other between 5.0 and 100 μM (with a slope of 0.48 μA μM-1). A limit of detection of 70 nM was achieved with this simple device that provided accurate results with an RSD of ca. 5%. The platform was applied for diclofenac quantification in spiked tap water samples. The versatility of this design enabled the fabrication of a multiplexed platform containing eight electrochemical cells that work independently. The low cost, small size and simplicity of the device allow on-site analysis, which is very useful for environmental monitoring.The authors would like to thank the EU and FCT/UEFISCDI/FORMAS for funding, in the frame of the collaborative internationalconsortium REWATERfinanced under the ERA-NET CofundWaterWorks 2015 Call. This ERA-NET is an integral part of the 2016Joint Activities developed by the Water Challenges for a ChangingWorld Joint Programme Initiative (Water JPI). This work was alsosupported by the EU (FEDER funds through COMPETE) and FCT(project FOODnanoHEALTH, Portugal2020, Norte-01-0145-FEDER-000011 and project UID/QUI/50006/2013) and by the SpanishMinistry of Economy and Competitiveness (MINECO, projectCTQ2014-58826-R). Estefanía Costa Rama thanks the Governmentof Principado de Asturias and Marie Curie-Cofund Actions for thepost-doctoral grant“Clarín-Cofund”ACA17-20.Repositório Científico do Instituto Politécnico do PortoCosta-Rama, E.Nouws, H.Delerue-Matos, CristinaBlanco-López, M.C.Fernández-Abedul, M.T.2020-07-10T13:06:10Z2019-10-032019-10-03T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/16091eng10.1016/j.aca.2019.05.016info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T13:01:34Zoai:recipp.ipp.pt:10400.22/16091Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:35:43.510892Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Preconcentration and sensitive determination of the anti-inflammatory drug diclofenac on a paper-based electroanalytical platform
title Preconcentration and sensitive determination of the anti-inflammatory drug diclofenac on a paper-based electroanalytical platform
spellingShingle Preconcentration and sensitive determination of the anti-inflammatory drug diclofenac on a paper-based electroanalytical platform
Costa-Rama, E.
Paper-based electroanalysis
Electroanalytical platforms
Multiplexing
Low-cost analysis
Anti-inflammatory drugs
Diclofenac
title_short Preconcentration and sensitive determination of the anti-inflammatory drug diclofenac on a paper-based electroanalytical platform
title_full Preconcentration and sensitive determination of the anti-inflammatory drug diclofenac on a paper-based electroanalytical platform
title_fullStr Preconcentration and sensitive determination of the anti-inflammatory drug diclofenac on a paper-based electroanalytical platform
title_full_unstemmed Preconcentration and sensitive determination of the anti-inflammatory drug diclofenac on a paper-based electroanalytical platform
title_sort Preconcentration and sensitive determination of the anti-inflammatory drug diclofenac on a paper-based electroanalytical platform
author Costa-Rama, E.
author_facet Costa-Rama, E.
Nouws, H.
Delerue-Matos, Cristina
Blanco-López, M.C.
Fernández-Abedul, M.T.
author_role author
author2 Nouws, H.
Delerue-Matos, Cristina
Blanco-López, M.C.
Fernández-Abedul, M.T.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Costa-Rama, E.
Nouws, H.
Delerue-Matos, Cristina
Blanco-López, M.C.
Fernández-Abedul, M.T.
dc.subject.por.fl_str_mv Paper-based electroanalysis
Electroanalytical platforms
Multiplexing
Low-cost analysis
Anti-inflammatory drugs
Diclofenac
topic Paper-based electroanalysis
Electroanalytical platforms
Multiplexing
Low-cost analysis
Anti-inflammatory drugs
Diclofenac
description This work describes the development of a paper-based platform for highly sensitive detection of diclofenac. The quantification of this anti-inflammatory drug is of importance in clinical (e.g. quality and therapeutic control) and environmental (e.g. emerging contaminant determination) areas. The easy-to-handle platform here described consists of a carbon-ink paper-based working electrode and two metallic wires, provided by a gold-plated standard connector, as reference and counter electrodes. The porous paper matrix enables the preconcentration of the sample, decoupling sample and detection solutions. Thus, relatively large sample volumes can be used, which significantly improves the sensitivity of the method. A wide dynamic range of four orders of magnitude, between 0.10 and 100 μM, was obtained for diclofenac determination. Due to the predominance of adsorption at the lowest concentrations, there were two linear concentration ranges: one comprised between 0.10 and 5.0 μM (with a slope of 0.85 μA μM-1) and the other between 5.0 and 100 μM (with a slope of 0.48 μA μM-1). A limit of detection of 70 nM was achieved with this simple device that provided accurate results with an RSD of ca. 5%. The platform was applied for diclofenac quantification in spiked tap water samples. The versatility of this design enabled the fabrication of a multiplexed platform containing eight electrochemical cells that work independently. The low cost, small size and simplicity of the device allow on-site analysis, which is very useful for environmental monitoring.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-03
2019-10-03T00:00:00Z
2020-07-10T13:06:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/16091
url http://hdl.handle.net/10400.22/16091
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.aca.2019.05.016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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