Metabolic Bone Disease of Prematurity in Very Low Birthweight Infants: Retrospective Observational Study
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10994 |
Resumo: | Introduction: Metabolic bone disease of prematurity consists in a decrease of bone matrix mineral content, in comparison with the level expected for gestational age. Screening of this condition is based on serum alkaline phosphatase and phosphate levels. The aim of this study is to evaluate the prevalence of metabolic bone disease of prematurity, to assess the aspects associated with a higher risk of this disease and to describe the growth of newborns with birth weight below 1500 g and metabolic bone disease of prematurity.Material and Methods: Observational, retrospective, multicenter and descriptive study in three neonatal intensive care units in Portugal, from May 1st 2016 to April 30th 2017. A convenience sample of very low birthweight newborns was obtained. Demographic, clinical, and laboratory variables were described in newborns with and without metabolic bone disease of prematurity.Results: A total of 53 newborns were included in this study: 30 males, 16 with gestational age ≤ 28 weeks. Five cases of metabolic bone disease of prematurity were diagnosed. In this group, the majority of patients was male and presented a lower gestational age and birth weight, in comparison with the group without metabolic bone disease of prematurity. The average duration of parenteral nutrition was higher in newborns with metabolic bone disease of prematurity and the calcium/phosphate ratio was lower than the recommended values. Growth was similar in both groups. No patient with metabolic bone disease of prematurity underwent physical rehabilitation.Discussion: The prevalence of metabolic bone disease of prematurity was 9.43%, which is lower than what is described in the literature. However, only 50% of newborns completed the screening according to the recommendations. The main risk factors identified concur with the literature.Conclusion: Metabolic bone disease of prematurity is a frequent but underdiagnosed comorbidity in very low birthweight newborns. It is essential to screen newborns at risk for this condition, using biochemical markers, as well as structure nutritional interventions and physical stimulation in order to avoid short and long-term consequences of this disease. |
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Metabolic Bone Disease of Prematurity in Very Low Birthweight Infants: Retrospective Observational StudyDoença Metabólica Óssea da Prematuridade em Recém-Nascidos de Muito Baixo Peso: Estudo Observacional RetrospetivoBone DiseasesMetabolicInfantExtremely Low Birth WeightPrematureDiseasesNutritional StatusDoenças Ósseas MetabólicasDoenças do PrematuroEstado NutricionalRecém-Nascido de Peso Extremamente Baixo ao NascerRecém-Nascido PrematuroIntroduction: Metabolic bone disease of prematurity consists in a decrease of bone matrix mineral content, in comparison with the level expected for gestational age. Screening of this condition is based on serum alkaline phosphatase and phosphate levels. The aim of this study is to evaluate the prevalence of metabolic bone disease of prematurity, to assess the aspects associated with a higher risk of this disease and to describe the growth of newborns with birth weight below 1500 g and metabolic bone disease of prematurity.Material and Methods: Observational, retrospective, multicenter and descriptive study in three neonatal intensive care units in Portugal, from May 1st 2016 to April 30th 2017. A convenience sample of very low birthweight newborns was obtained. Demographic, clinical, and laboratory variables were described in newborns with and without metabolic bone disease of prematurity.Results: A total of 53 newborns were included in this study: 30 males, 16 with gestational age ≤ 28 weeks. Five cases of metabolic bone disease of prematurity were diagnosed. In this group, the majority of patients was male and presented a lower gestational age and birth weight, in comparison with the group without metabolic bone disease of prematurity. The average duration of parenteral nutrition was higher in newborns with metabolic bone disease of prematurity and the calcium/phosphate ratio was lower than the recommended values. Growth was similar in both groups. No patient with metabolic bone disease of prematurity underwent physical rehabilitation.Discussion: The prevalence of metabolic bone disease of prematurity was 9.43%, which is lower than what is described in the literature. However, only 50% of newborns completed the screening according to the recommendations. The main risk factors identified concur with the literature.Conclusion: Metabolic bone disease of prematurity is a frequent but underdiagnosed comorbidity in very low birthweight newborns. It is essential to screen newborns at risk for this condition, using biochemical markers, as well as structure nutritional interventions and physical stimulation in order to avoid short and long-term consequences of this disease.Introdução: A doença metabólica óssea da prematuridade consiste numa diminuição da matriz óssea, relativamente ao nível esperado para a idade gestacional. O rastreio baseia-se no doseamento sérico da fosfatase alcalina e fósforo. O objetivo deste estudo é avaliar a prevalência da doença metabólica óssea da prematuridade, analisar os aspetos associados a maior risco para esta doença e descrever o crescimento estaturo-ponderal dos recém-nascidos com peso ao nascer inferior a 1500 g, com doença metabólica óssea da prematuridade.Material e Métodos: Estudo multicêntrico, retrospetivo, observacional e descritivo em três unidades de apoio perinatal diferenciado, entre 1 de maio de 2016 e 30 de abril de 2017; foi obtida uma amostra de conveniência de recém-nascidos com muito baixo peso ao nascer. Descrevem-se as variáveis demográficas, clínicas e laboratoriais dos recém-nascidos com e sem doença metabólica óssea da prematuridade.Resultados: Neste estudo foram incluídos 53 recém-nascidos: 30 do sexo masculino, 16 com idade gestacional ≤ 28 semanas. Foram diagnosticados cinco casos de doença metabólica óssea da prematuridade. Neste grupo, a maioria dos doentes era do sexo masculino e apresentavam idade gestacional e peso ao nascer inferior aos do grupo sem doença metabólica óssea da prematuridade. A duração média de nutrição parentérica foi superior nos recém-nascidos com doença metabólica óssea da prematuridade e a relação cálcio/fósforo utilizada foi inferior às recomendações nacionais. A evolução estaturo-ponderal foi semelhante nos recém-nascidos com e sem doença. Nenhum doente com doença metabólica óssea da prematuridade teve intervenção por medicina física e reabilitação.Discussão: A prevalência de doença metabólica óssea da prematuridade foi de 9,43%, valor inferior ao descrito na literatura. Contudo, apenas 50% dos recém-nascidos cumpriram o rastreio de acordo com as recomendações. Os principais fatores de risco identificados estão de acordo com a literatura.Conclusão: A doença metabólica óssea da prematuridade é uma comorbilidade frequente nos recém-nascidos de muito baixo peso, mas encontra-se subdiagnosticada. É fundamental rastrear os recém-nascidos em risco para esta patologia, utilizando marcadores bioquímicos, assim como estruturar intervenções nutricionais e estimulação física para evitar as consequências da doença a curto e longo prazo.Ordem dos Médicos2019-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10994oai:ojs.www.actamedicaportuguesa.com:article/10994Acta Médica Portuguesa; Vol. 32 No. 7-8 (2019): July-August; 536-541Acta Médica Portuguesa; Vol. 32 N.º 7-8 (2019): Julho-Agosto; 536-5411646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10994https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10994/5739https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10994/6126https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10994/10492https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10994/10493Direitos de Autor (c) 2019 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessCosta, RaquelFranco, CatarinaSantos, NádiaMaio, PatríciaVieira, FilipaAntunes, SóniaMartins, LauraTuna, Madalena Lopo2022-12-20T11:06:09Zoai:ojs.www.actamedicaportuguesa.com:article/10994Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:58.812138Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Metabolic Bone Disease of Prematurity in Very Low Birthweight Infants: Retrospective Observational Study Doença Metabólica Óssea da Prematuridade em Recém-Nascidos de Muito Baixo Peso: Estudo Observacional Retrospetivo |
title |
Metabolic Bone Disease of Prematurity in Very Low Birthweight Infants: Retrospective Observational Study |
spellingShingle |
Metabolic Bone Disease of Prematurity in Very Low Birthweight Infants: Retrospective Observational Study Costa, Raquel Bone Diseases Metabolic Infant Extremely Low Birth Weight Premature Diseases Nutritional Status Doenças Ósseas Metabólicas Doenças do Prematuro Estado Nutricional Recém-Nascido de Peso Extremamente Baixo ao Nascer Recém-Nascido Prematuro |
title_short |
Metabolic Bone Disease of Prematurity in Very Low Birthweight Infants: Retrospective Observational Study |
title_full |
Metabolic Bone Disease of Prematurity in Very Low Birthweight Infants: Retrospective Observational Study |
title_fullStr |
Metabolic Bone Disease of Prematurity in Very Low Birthweight Infants: Retrospective Observational Study |
title_full_unstemmed |
Metabolic Bone Disease of Prematurity in Very Low Birthweight Infants: Retrospective Observational Study |
title_sort |
Metabolic Bone Disease of Prematurity in Very Low Birthweight Infants: Retrospective Observational Study |
author |
Costa, Raquel |
author_facet |
Costa, Raquel Franco, Catarina Santos, Nádia Maio, Patrícia Vieira, Filipa Antunes, Sónia Martins, Laura Tuna, Madalena Lopo |
author_role |
author |
author2 |
Franco, Catarina Santos, Nádia Maio, Patrícia Vieira, Filipa Antunes, Sónia Martins, Laura Tuna, Madalena Lopo |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Costa, Raquel Franco, Catarina Santos, Nádia Maio, Patrícia Vieira, Filipa Antunes, Sónia Martins, Laura Tuna, Madalena Lopo |
dc.subject.por.fl_str_mv |
Bone Diseases Metabolic Infant Extremely Low Birth Weight Premature Diseases Nutritional Status Doenças Ósseas Metabólicas Doenças do Prematuro Estado Nutricional Recém-Nascido de Peso Extremamente Baixo ao Nascer Recém-Nascido Prematuro |
topic |
Bone Diseases Metabolic Infant Extremely Low Birth Weight Premature Diseases Nutritional Status Doenças Ósseas Metabólicas Doenças do Prematuro Estado Nutricional Recém-Nascido de Peso Extremamente Baixo ao Nascer Recém-Nascido Prematuro |
description |
Introduction: Metabolic bone disease of prematurity consists in a decrease of bone matrix mineral content, in comparison with the level expected for gestational age. Screening of this condition is based on serum alkaline phosphatase and phosphate levels. The aim of this study is to evaluate the prevalence of metabolic bone disease of prematurity, to assess the aspects associated with a higher risk of this disease and to describe the growth of newborns with birth weight below 1500 g and metabolic bone disease of prematurity.Material and Methods: Observational, retrospective, multicenter and descriptive study in three neonatal intensive care units in Portugal, from May 1st 2016 to April 30th 2017. A convenience sample of very low birthweight newborns was obtained. Demographic, clinical, and laboratory variables were described in newborns with and without metabolic bone disease of prematurity.Results: A total of 53 newborns were included in this study: 30 males, 16 with gestational age ≤ 28 weeks. Five cases of metabolic bone disease of prematurity were diagnosed. In this group, the majority of patients was male and presented a lower gestational age and birth weight, in comparison with the group without metabolic bone disease of prematurity. The average duration of parenteral nutrition was higher in newborns with metabolic bone disease of prematurity and the calcium/phosphate ratio was lower than the recommended values. Growth was similar in both groups. No patient with metabolic bone disease of prematurity underwent physical rehabilitation.Discussion: The prevalence of metabolic bone disease of prematurity was 9.43%, which is lower than what is described in the literature. However, only 50% of newborns completed the screening according to the recommendations. The main risk factors identified concur with the literature.Conclusion: Metabolic bone disease of prematurity is a frequent but underdiagnosed comorbidity in very low birthweight newborns. It is essential to screen newborns at risk for this condition, using biochemical markers, as well as structure nutritional interventions and physical stimulation in order to avoid short and long-term consequences of this disease. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10994 oai:ojs.www.actamedicaportuguesa.com:article/10994 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10994 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/10994 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10994 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10994/5739 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10994/6126 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10994/10492 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10994/10493 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2019 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
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Direitos de Autor (c) 2019 Acta Médica Portuguesa |
eu_rights_str_mv |
openAccess |
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application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 32 No. 7-8 (2019): July-August; 536-541 Acta Médica Portuguesa; Vol. 32 N.º 7-8 (2019): Julho-Agosto; 536-541 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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