Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.4/226 |
Resumo: | Toxic Epidermal Necrolysis (Lyell's syndrome) is a rare but very serious dermatological lesion, characterized by the sudden onset of high fever, signs of systemic toxicity and intense mucocutaneous exfoliation. Its pathophysiology is not yet well determined, although it is almost consensual the presence of an immunological basis. It appears usually as an answer to the taking of a given drug, and, in spite of being self-limited in the absence of complications, if not well managed it is associated with great morbidity and a high mortality, due, in most cases, to the developing of sepsis. Treatment includes mainly the immediate suspension of the inducing drug and the precocious admission of the patient in a hospital facility with the capacity to provide intensive support care and to minimize the infectious risk, having also the conditions for the execution of surgical debridement and covering of the affected areas, that is to say in Burn Units. There are in study several therapeutical measures designed to lower the morbidity and mortality of this syndrome, namely the use of plasmapheresis; the administration of high doses of N-acetylcysteine; immunosuppression; hyperbaric oxygen, etc. The authors present the treatment protocol in use at the Coimbra Burns Unit, in Portugal, illustrated with a clinical case from that Unit |
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Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de QueimadosToxic Epidermal Necrolysis (Lyell syndrome): a pathology for burn unitsNecrólise Epidérmica TóxicaUnidades de QueimadosToxic Epidermal Necrolysis (Lyell's syndrome) is a rare but very serious dermatological lesion, characterized by the sudden onset of high fever, signs of systemic toxicity and intense mucocutaneous exfoliation. Its pathophysiology is not yet well determined, although it is almost consensual the presence of an immunological basis. It appears usually as an answer to the taking of a given drug, and, in spite of being self-limited in the absence of complications, if not well managed it is associated with great morbidity and a high mortality, due, in most cases, to the developing of sepsis. Treatment includes mainly the immediate suspension of the inducing drug and the precocious admission of the patient in a hospital facility with the capacity to provide intensive support care and to minimize the infectious risk, having also the conditions for the execution of surgical debridement and covering of the affected areas, that is to say in Burn Units. There are in study several therapeutical measures designed to lower the morbidity and mortality of this syndrome, namely the use of plasmapheresis; the administration of high doses of N-acetylcysteine; immunosuppression; hyperbaric oxygen, etc. The authors present the treatment protocol in use at the Coimbra Burns Unit, in Portugal, illustrated with a clinical case from that UnitCentro Editor Livreiro da Ordem dos MédicosRIHUCCabral, LDiogo, CRiobom, FTeles, LCruzeiro, C2008-11-28T12:57:32Z20042004-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.4/226porActa Med Port. 2004 Mar-Apr;17(2):129-40info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-11T14:21:22Zoai:rihuc.huc.min-saude.pt:10400.4/226Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:03:03.868578Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados Toxic Epidermal Necrolysis (Lyell syndrome): a pathology for burn units |
title |
Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados |
spellingShingle |
Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados Cabral, L Necrólise Epidérmica Tóxica Unidades de Queimados |
title_short |
Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados |
title_full |
Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados |
title_fullStr |
Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados |
title_full_unstemmed |
Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados |
title_sort |
Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados |
author |
Cabral, L |
author_facet |
Cabral, L Diogo, C Riobom, F Teles, L Cruzeiro, C |
author_role |
author |
author2 |
Diogo, C Riobom, F Teles, L Cruzeiro, C |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
RIHUC |
dc.contributor.author.fl_str_mv |
Cabral, L Diogo, C Riobom, F Teles, L Cruzeiro, C |
dc.subject.por.fl_str_mv |
Necrólise Epidérmica Tóxica Unidades de Queimados |
topic |
Necrólise Epidérmica Tóxica Unidades de Queimados |
description |
Toxic Epidermal Necrolysis (Lyell's syndrome) is a rare but very serious dermatological lesion, characterized by the sudden onset of high fever, signs of systemic toxicity and intense mucocutaneous exfoliation. Its pathophysiology is not yet well determined, although it is almost consensual the presence of an immunological basis. It appears usually as an answer to the taking of a given drug, and, in spite of being self-limited in the absence of complications, if not well managed it is associated with great morbidity and a high mortality, due, in most cases, to the developing of sepsis. Treatment includes mainly the immediate suspension of the inducing drug and the precocious admission of the patient in a hospital facility with the capacity to provide intensive support care and to minimize the infectious risk, having also the conditions for the execution of surgical debridement and covering of the affected areas, that is to say in Burn Units. There are in study several therapeutical measures designed to lower the morbidity and mortality of this syndrome, namely the use of plasmapheresis; the administration of high doses of N-acetylcysteine; immunosuppression; hyperbaric oxygen, etc. The authors present the treatment protocol in use at the Coimbra Burns Unit, in Portugal, illustrated with a clinical case from that Unit |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004 2004-01-01T00:00:00Z 2008-11-28T12:57:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.4/226 |
url |
http://hdl.handle.net/10400.4/226 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Acta Med Port. 2004 Mar-Apr;17(2):129-40 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Centro Editor Livreiro da Ordem dos Médicos |
publisher.none.fl_str_mv |
Centro Editor Livreiro da Ordem dos Médicos |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799131695575728128 |