Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados

Detalhes bibliográficos
Autor(a) principal: Cabral, L
Data de Publicação: 2004
Outros Autores: Diogo, C, Riobom, F, Teles, L, Cruzeiro, C
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.4/226
Resumo: Toxic Epidermal Necrolysis (Lyell's syndrome) is a rare but very serious dermatological lesion, characterized by the sudden onset of high fever, signs of systemic toxicity and intense mucocutaneous exfoliation. Its pathophysiology is not yet well determined, although it is almost consensual the presence of an immunological basis. It appears usually as an answer to the taking of a given drug, and, in spite of being self-limited in the absence of complications, if not well managed it is associated with great morbidity and a high mortality, due, in most cases, to the developing of sepsis. Treatment includes mainly the immediate suspension of the inducing drug and the precocious admission of the patient in a hospital facility with the capacity to provide intensive support care and to minimize the infectious risk, having also the conditions for the execution of surgical debridement and covering of the affected areas, that is to say in Burn Units. There are in study several therapeutical measures designed to lower the morbidity and mortality of this syndrome, namely the use of plasmapheresis; the administration of high doses of N-acetylcysteine; immunosuppression; hyperbaric oxygen, etc. The authors present the treatment protocol in use at the Coimbra Burns Unit, in Portugal, illustrated with a clinical case from that Unit
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spelling Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de QueimadosToxic Epidermal Necrolysis (Lyell syndrome): a pathology for burn unitsNecrólise Epidérmica TóxicaUnidades de QueimadosToxic Epidermal Necrolysis (Lyell's syndrome) is a rare but very serious dermatological lesion, characterized by the sudden onset of high fever, signs of systemic toxicity and intense mucocutaneous exfoliation. Its pathophysiology is not yet well determined, although it is almost consensual the presence of an immunological basis. It appears usually as an answer to the taking of a given drug, and, in spite of being self-limited in the absence of complications, if not well managed it is associated with great morbidity and a high mortality, due, in most cases, to the developing of sepsis. Treatment includes mainly the immediate suspension of the inducing drug and the precocious admission of the patient in a hospital facility with the capacity to provide intensive support care and to minimize the infectious risk, having also the conditions for the execution of surgical debridement and covering of the affected areas, that is to say in Burn Units. There are in study several therapeutical measures designed to lower the morbidity and mortality of this syndrome, namely the use of plasmapheresis; the administration of high doses of N-acetylcysteine; immunosuppression; hyperbaric oxygen, etc. The authors present the treatment protocol in use at the Coimbra Burns Unit, in Portugal, illustrated with a clinical case from that UnitCentro Editor Livreiro da Ordem dos MédicosRIHUCCabral, LDiogo, CRiobom, FTeles, LCruzeiro, C2008-11-28T12:57:32Z20042004-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.4/226porActa Med Port. 2004 Mar-Apr;17(2):129-40info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-11T14:21:22Zoai:rihuc.huc.min-saude.pt:10400.4/226Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:03:03.868578Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados
Toxic Epidermal Necrolysis (Lyell syndrome): a pathology for burn units
title Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados
spellingShingle Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados
Cabral, L
Necrólise Epidérmica Tóxica
Unidades de Queimados
title_short Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados
title_full Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados
title_fullStr Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados
title_full_unstemmed Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados
title_sort Necrólise Epidérmica Tóxica (Síndrome de Lyell): uma patologia para as Unidades de Queimados
author Cabral, L
author_facet Cabral, L
Diogo, C
Riobom, F
Teles, L
Cruzeiro, C
author_role author
author2 Diogo, C
Riobom, F
Teles, L
Cruzeiro, C
author2_role author
author
author
author
dc.contributor.none.fl_str_mv RIHUC
dc.contributor.author.fl_str_mv Cabral, L
Diogo, C
Riobom, F
Teles, L
Cruzeiro, C
dc.subject.por.fl_str_mv Necrólise Epidérmica Tóxica
Unidades de Queimados
topic Necrólise Epidérmica Tóxica
Unidades de Queimados
description Toxic Epidermal Necrolysis (Lyell's syndrome) is a rare but very serious dermatological lesion, characterized by the sudden onset of high fever, signs of systemic toxicity and intense mucocutaneous exfoliation. Its pathophysiology is not yet well determined, although it is almost consensual the presence of an immunological basis. It appears usually as an answer to the taking of a given drug, and, in spite of being self-limited in the absence of complications, if not well managed it is associated with great morbidity and a high mortality, due, in most cases, to the developing of sepsis. Treatment includes mainly the immediate suspension of the inducing drug and the precocious admission of the patient in a hospital facility with the capacity to provide intensive support care and to minimize the infectious risk, having also the conditions for the execution of surgical debridement and covering of the affected areas, that is to say in Burn Units. There are in study several therapeutical measures designed to lower the morbidity and mortality of this syndrome, namely the use of plasmapheresis; the administration of high doses of N-acetylcysteine; immunosuppression; hyperbaric oxygen, etc. The authors present the treatment protocol in use at the Coimbra Burns Unit, in Portugal, illustrated with a clinical case from that Unit
publishDate 2004
dc.date.none.fl_str_mv 2004
2004-01-01T00:00:00Z
2008-11-28T12:57:32Z
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dc.relation.none.fl_str_mv Acta Med Port. 2004 Mar-Apr;17(2):129-40
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