Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation

Detalhes bibliográficos
Autor(a) principal: Jennifer Noro
Data de Publicação: 2017
Outros Autores: Loureiro, Ana Isabel Sá, Gonçalves, Filipa D., Azóia, Nuno G., Jung, Seunho, Silva, Carla, Cavaco-Paulo, Artur
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/47808
Resumo: New encapsulation nanodevices were synthesized by emulsification of cyclo-oligosaccharides fully substituted by hydrophobic palmitic chains. These highly hydrophobic compounds, acquire oily-like behaviour at moderate temperatures (50 °C) and when submitted to ultrasounds (US) can undergo emulsification. The improved emulsifying properties of modified cyclo-oligosaccharides are suitable to produce small and narrow sized nanoemulsions with ability to encapsulate amphiphilic molecules. Both encapsulation and delivery of a therapeutic drug, methotrexate (MTX), with amphiphilic character was assessed. The physicochemical properties of the cyclo-oligosaccharide nanoemulsions containing MTX were investigated by nuclear magnetic resonance (NMR), scanning transmission electron microscopy (STEM) and dynamic light scattering (DLS). The results revealed that the modified cyclo-oligosaccharides are potential platforms for the encapsulation of bio compounds for cosmetic and pharmaceutical purposes.
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spelling Oil-based cyclo-oligosaccharide nanodevices for drug encapsulationCyclo-oligosaccharidescyclosophoraosepalmitoyl chloridephase-changenanoemulsionsultrasoundScience & TechnologyNew encapsulation nanodevices were synthesized by emulsification of cyclo-oligosaccharides fully substituted by hydrophobic palmitic chains. These highly hydrophobic compounds, acquire oily-like behaviour at moderate temperatures (50 °C) and when submitted to ultrasounds (US) can undergo emulsification. The improved emulsifying properties of modified cyclo-oligosaccharides are suitable to produce small and narrow sized nanoemulsions with ability to encapsulate amphiphilic molecules. Both encapsulation and delivery of a therapeutic drug, methotrexate (MTX), with amphiphilic character was assessed. The physicochemical properties of the cyclo-oligosaccharide nanoemulsions containing MTX were investigated by nuclear magnetic resonance (NMR), scanning transmission electron microscopy (STEM) and dynamic light scattering (DLS). The results revealed that the modified cyclo-oligosaccharides are potential platforms for the encapsulation of bio compounds for cosmetic and pharmaceutical purposes.ERDF -European Regional Development Fundinfo:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoJennifer NoroLoureiro, Ana Isabel SáGonçalves, Filipa D.Azóia, Nuno G.Jung, SeunhoSilva, CarlaCavaco-Paulo, Artur2017-112017-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/47808engJennifer Noro; Loureiro, Ana; Gonçalves, Filipa D.; Azoia, Nuno G.; Jung, Seunho; Silva, Carla; Cavaco-Paulo, Artur, Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation. Colloids and Surfaces B: Biointerfaces, 159, 259-267, 2017092777650927-776510.1016/j.colsurfb.2017.07.05528800465http://www.journals.elsevier.com/colloids-and-surfaces-b-biointerfaces/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T04:18:37Zoai:repositorium.sdum.uminho.pt:1822/47808Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T04:18:37Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
title Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
spellingShingle Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
Jennifer Noro
Cyclo-oligosaccharides
cyclosophoraose
palmitoyl chloride
phase-change
nanoemulsions
ultrasound
Science & Technology
title_short Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
title_full Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
title_fullStr Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
title_full_unstemmed Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
title_sort Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
author Jennifer Noro
author_facet Jennifer Noro
Loureiro, Ana Isabel Sá
Gonçalves, Filipa D.
Azóia, Nuno G.
Jung, Seunho
Silva, Carla
Cavaco-Paulo, Artur
author_role author
author2 Loureiro, Ana Isabel Sá
Gonçalves, Filipa D.
Azóia, Nuno G.
Jung, Seunho
Silva, Carla
Cavaco-Paulo, Artur
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Jennifer Noro
Loureiro, Ana Isabel Sá
Gonçalves, Filipa D.
Azóia, Nuno G.
Jung, Seunho
Silva, Carla
Cavaco-Paulo, Artur
dc.subject.por.fl_str_mv Cyclo-oligosaccharides
cyclosophoraose
palmitoyl chloride
phase-change
nanoemulsions
ultrasound
Science & Technology
topic Cyclo-oligosaccharides
cyclosophoraose
palmitoyl chloride
phase-change
nanoemulsions
ultrasound
Science & Technology
description New encapsulation nanodevices were synthesized by emulsification of cyclo-oligosaccharides fully substituted by hydrophobic palmitic chains. These highly hydrophobic compounds, acquire oily-like behaviour at moderate temperatures (50 °C) and when submitted to ultrasounds (US) can undergo emulsification. The improved emulsifying properties of modified cyclo-oligosaccharides are suitable to produce small and narrow sized nanoemulsions with ability to encapsulate amphiphilic molecules. Both encapsulation and delivery of a therapeutic drug, methotrexate (MTX), with amphiphilic character was assessed. The physicochemical properties of the cyclo-oligosaccharide nanoemulsions containing MTX were investigated by nuclear magnetic resonance (NMR), scanning transmission electron microscopy (STEM) and dynamic light scattering (DLS). The results revealed that the modified cyclo-oligosaccharides are potential platforms for the encapsulation of bio compounds for cosmetic and pharmaceutical purposes.
publishDate 2017
dc.date.none.fl_str_mv 2017-11
2017-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/47808
url http://hdl.handle.net/1822/47808
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Jennifer Noro; Loureiro, Ana; Gonçalves, Filipa D.; Azoia, Nuno G.; Jung, Seunho; Silva, Carla; Cavaco-Paulo, Artur, Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation. Colloids and Surfaces B: Biointerfaces, 159, 259-267, 2017
09277765
0927-7765
10.1016/j.colsurfb.2017.07.055
28800465
http://www.journals.elsevier.com/colloids-and-surfaces-b-biointerfaces/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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