Massive introgression drives species radiation at the range limit of Anopheles gambiae

• Autor(a) principal: Vicente, José L.
• Data de Publicação: 2017
• Outros Autores: Clarkson, Christopher S., Caputo, Beniamino, Gomes, Bruno, Pombi, Marco, Sousa, Carla A., Antao, Tiago, DInis, Joaõ, Bottà, Giordano, Mancini, Emiliano, Petrarca, Vincenzo, Mead, Daniel, Drury, Eleanor, Stalker, James, Miles, Alistair, Kwiatkowski, Dominic P., Donnelly, Martin J., Rodrigues, Amabélia, Torre, Alessandra Della, Weetman, David, Pinto, João
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://doi.org/10.1038/srep46451
• topic: MALARIA VECTOR MOSQUITOS; MOLECULAR-FORMS; GENE-FLOW; INCIPIENT SPECIATION; POPULATION-STRUCTURE; S FORMS; ASYMMETRIC INTROGRESSION;; ADAPTIVE INTROGRESSION;; INSECTICIDE RESISTANCE; GENOMIC DIVERGENCE; Ecology, Evolution, Behavior and Systematics; Insect Science; Infectious Diseases; SDG 15 - Life on Land; SDG 3 - Good Health and Well-being

Impacts of introgressive hybridisation may range from genomic erosion and species collapse to rapid adaptation and speciation but opportunities to study these dynamics are rare. We investigated the extent, causes and consequences of a hybrid zone between Anopheles coluzzii and Anopheles gambiae in Guinea-Bissau, where high hybridisation rates appear to be stable at least since the 1990s. Anopheles gambiae was genetically partitioned into inland and coastal subpopulations, separated by a central region dominated by A. coluzzii. Surprisingly, whole genome sequencing revealed that the coastal region harbours a hybrid form characterised by an A. gambiae-like sex chromosome and massive introgression of A. coluzzii autosomal alleles. Local selection on chromosomal inversions may play a role in this process, suggesting potential for spatiotemporal stability of the coastal hybrid form and providing resilience against introgression of medically-important loci and traits, found to be more prevalent in inland A. gambiae.