Uncovering the burden of Influenza in children in Portugal, 2008–2018
| Autor(a) principal: | |
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| Data de Publicação: | 2024 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/162977 |
Resumo: | Funding Information: The BARI study was funded by Sanofi. Publisher Copyright: © 2024, The Author(s). |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Uncovering the burden of Influenza in children in Portugal, 2008–2018BurdenChildrenExcessHealthyHospitalizationInfluenzaMortalityPortugalInfectious DiseasesSDG 3 - Good Health and Well-beingFunding Information: The BARI study was funded by Sanofi. Publisher Copyright: © 2024, The Author(s).Background: Despite their higher risk of developing severe disease, little is known about the burden of influenza in Portugal in children aged < 5 years old. This study aims to cover this gap by estimating the clinical and economic burden of severe influenza in children, in Portugal, during ten consecutive influenza seasons (2008/09-2017/18). Methods: We reviewed hospitalizations in children aged < 5 years old using anonymized administrative data covering all public hospitals discharges in mainland Portugal. The burden of hospitalization and in-hospital mortality directly coded as due to influenza was supplemented by the indirect burden calculated from excess hospitalization and mortality (influenza-associated), estimated for four groups of diagnoses (pneumonia or influenza, respiratory, respiratory or cardiovascular, and all-cause), through cyclic regression models integrating the incidence of influenza. Means were reported excluding the H1N1pdm09 pandemic (2009/10). Results: The mean annual number of hospitalizations coded as due to influenza was 189 (41.3 cases per 100,000 children aged < 5 years old). Hospitalization rates decreased with increasing age. Nine-in-ten children were previously healthy, but the presence of comorbidities increased with age. Children stayed, on average, 6.1 days at the hospital. Invasive mechanical ventilation was used in 2.4% of hospitalizations and non-invasive in 3.1%. Influenza-associated excess hospitalizations between 2008 and 2018 were estimated at 1,850 in pneumonia or influenza, 1,760 in respiratory, 1,787 in respiratory or cardiovascular, and 1,879 in all-cause models. A total of 95 influenza-associated excess deaths were estimated in all-cause, 14 in respiratory or cardiovascular, and 9 in respiratory models. Over ten years, influenza hospitalizations were estimated to have cost the National Health Service at least €2.9 million, of which 66.5% from healthy children. Conclusions: Influenza viruses led to a high number of hospitalizations in children. Most were previously healthy. Results should lead to a reflection on the adequate preventive measures to protect this age group.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Escola Nacional de Saúde Pública (ENSP)Centro de Investigação em Saúde Pública (CISP/PHRC)Comprehensive Health Research Centre (CHRC) - Pólo ENSPRUNCaldas Afonso, AlbertoGouveia, CatarinaJanuário, GustavoCarmo, MafaldaLopes, HugoBricout, HélèneGomes, CatarinaFroes, Filipe2024-01-31T23:35:56Z2024-01-182024-01-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/162977eng2374-4235PURE: 82425270https://doi.org/10.1186/s12879-023-08685-zinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:46:01Zoai:run.unl.pt:10362/162977Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:59:12.829770Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Uncovering the burden of Influenza in children in Portugal, 2008–2018 |
| title |
Uncovering the burden of Influenza in children in Portugal, 2008–2018 |
| spellingShingle |
Uncovering the burden of Influenza in children in Portugal, 2008–2018 Caldas Afonso, Alberto Burden Children Excess Healthy Hospitalization Influenza Mortality Portugal Infectious Diseases SDG 3 - Good Health and Well-being |
| title_short |
Uncovering the burden of Influenza in children in Portugal, 2008–2018 |
| title_full |
Uncovering the burden of Influenza in children in Portugal, 2008–2018 |
| title_fullStr |
Uncovering the burden of Influenza in children in Portugal, 2008–2018 |
| title_full_unstemmed |
Uncovering the burden of Influenza in children in Portugal, 2008–2018 |
| title_sort |
Uncovering the burden of Influenza in children in Portugal, 2008–2018 |
| author |
Caldas Afonso, Alberto |
| author_facet |
Caldas Afonso, Alberto Gouveia, Catarina Januário, Gustavo Carmo, Mafalda Lopes, Hugo Bricout, Hélène Gomes, Catarina Froes, Filipe |
| author_role |
author |
| author2 |
Gouveia, Catarina Januário, Gustavo Carmo, Mafalda Lopes, Hugo Bricout, Hélène Gomes, Catarina Froes, Filipe |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Escola Nacional de Saúde Pública (ENSP) Centro de Investigação em Saúde Pública (CISP/PHRC) Comprehensive Health Research Centre (CHRC) - Pólo ENSP RUN |
| dc.contributor.author.fl_str_mv |
Caldas Afonso, Alberto Gouveia, Catarina Januário, Gustavo Carmo, Mafalda Lopes, Hugo Bricout, Hélène Gomes, Catarina Froes, Filipe |
| dc.subject.por.fl_str_mv |
Burden Children Excess Healthy Hospitalization Influenza Mortality Portugal Infectious Diseases SDG 3 - Good Health and Well-being |
| topic |
Burden Children Excess Healthy Hospitalization Influenza Mortality Portugal Infectious Diseases SDG 3 - Good Health and Well-being |
| description |
Funding Information: The BARI study was funded by Sanofi. Publisher Copyright: © 2024, The Author(s). |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024-01-31T23:35:56Z 2024-01-18 2024-01-18T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/162977 |
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http://hdl.handle.net/10362/162977 |
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eng |
| language |
eng |
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2374-4235 PURE: 82425270 https://doi.org/10.1186/s12879-023-08685-z |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138172211298304 |