Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors

Detalhes bibliográficos
Autor(a) principal: Temido Ferreira, Mariana
Data de Publicação: 2018
Outros Autores: Ferreira, Diana, Batalha, Vânia, Marques-Morgado, Inês, Coelho, Joana E, Pereira, Pedro, Gomes, Rui, Pinto, Andreia, Carvalho, Sara, Canas, Paula M., Cuvelier, Laetitia, Buée-Scherrer, Valerie, Faivre, Emilie, Baqi, Younis, Müller, Christa E., Pimentel, José, Schiffmann, Serge N., Buée, Luc, Bader, Michael, Outeiro, Tiago F., Blum, David, Cunha, Rodrigo A., Marie, Hélène, Pousinha, Paula, Lopes, Luísa V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/55389
Resumo: © The Author(s) 2018. This article is published with open access. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
id RCAP_d651a0b30906704a6f8a2f192d42d2da
oai_identifier_str oai:repositorio.ul.pt:10451/55389
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors© The Author(s) 2018. This article is published with open access. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Synaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drives the cognitive decline. An association between a polymorphism of the adenosine A2A receptor (A2AR) encoding gene-ADORA2A, and hippocampal volume in AD patients was recently described. In this study, we explore the synaptic function of A2AR in age-related conditions. We report, for the first time, a significant overexpression of A2AR in hippocampal neurons of aged humans, which is aggravated in AD patients. A similar profile of A2AR overexpression in rats was sufficient to drive age-like memory impairments in young animals and to uncover a hippocampal LTD-to-LTP shift. This was accompanied by increased NMDA receptor gating, dependent on mGluR5 and linked to enhanced Ca2+ influx. We confirmed the same plasticity shift in memory-impaired aged rats and APP/PS1 mice modeling AD, which was rescued upon A2AR blockade. This A2AR/mGluR5/NMDAR interaction might prove a suitable alternative for regulating aberrant mGluR5/NMDAR signaling in AD without disrupting their constitutive activity.MT-F is an FCT/PhD Fellow (IMM Lisbon BioMed PhD program; SFRH/BD/52228/2013); VLB, DGF and JEC were supported by a fellowship from Fundação para a Ciência e Tecnologia (FCT, Portugal); LVL is an Investigator FCT. TFO is supported by the DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain, Goettingen, Germany. RAC is supported by Maratona da Saúde, Santa Casa da Misericórdia and ERDF, through Centro 2020 (project CENTRO-01-0145-FEDER-000008:BrainHealth 2020), and through FCT (projects POCI-01-0145-FEDER-007440 and PTDC/NEU-NMC/4154/2016). DB, VBS, EF, and LB are supported by Région Hauts de France (PARTNAIRR COGNADORA), ANR (ADORATAU and SPREADTAU), LECMA/Alzheimer Forschung Initiative, Programs d’Investissements d’Avenir LabEx (excellence laboratory) DISTALZ (Development of Innovative Strategies for a Transdisciplinary approach to AD), France Alzheimer/Fondation de France, the FHU VasCog research network (Lille, France), Fondation pour la Recherche Médicale, Fondation Plan Alzheimer, INSERM, CNRS, Université Lille 2, Lille Métropole Communauté Urbaine, FEDER, DN2M, LICEND, and CoEN. LVL and DB are supported by AAP Internationalization, Université de Lille. EF is supported by ANR and Université de Lille. We would like to thank the Lille Neurobank for providing human brain tissues. HM and PAP supported by ATIP/AVENIR program (Center National de la Recherche Scientifique—CNRS), by the Foundation Plan Alzheimer (Senior Innovative Grant 2010) and PP by the Fondation pour la Recherche Médicale (FRM post-doctoral fellowship). Funded by LISBOA-01-0145-FEDER-007391, project co-financed by FEDER, POR Lisboa 2020—Programa Operacional Regional de Lisboa, from PORTUGAL 2020 and by Fundação para a Ciência e a Tecnologia (PTDC/BIM-MEC/47778/2014).Springer NatureRepositório da Universidade de LisboaTemido Ferreira, MarianaFerreira, DianaBatalha, VâniaMarques-Morgado, InêsCoelho, Joana EPereira, PedroGomes, RuiPinto, AndreiaCarvalho, SaraCanas, Paula M.Cuvelier, LaetitiaBuée-Scherrer, ValerieFaivre, EmilieBaqi, YounisMüller, Christa E.Pimentel, JoséSchiffmann, Serge N.Buée, LucBader, MichaelOuteiro, Tiago F.Blum, DavidCunha, Rodrigo A.Marie, HélènePousinha, PaulaLopes, Luísa V.2022-12-14T12:22:25Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/55389engMol Psychiatry. 2020 Aug;25(8):1876-19001359-418410.1038/s41380-018-0110-91476-5578info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:02:18Zoai:repositorio.ul.pt:10451/55389Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:06:02.406790Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors
title Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors
spellingShingle Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors
Temido Ferreira, Mariana
title_short Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors
title_full Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors
title_fullStr Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors
title_full_unstemmed Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors
title_sort Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors
author Temido Ferreira, Mariana
author_facet Temido Ferreira, Mariana
Ferreira, Diana
Batalha, Vânia
Marques-Morgado, Inês
Coelho, Joana E
Pereira, Pedro
Gomes, Rui
Pinto, Andreia
Carvalho, Sara
Canas, Paula M.
Cuvelier, Laetitia
Buée-Scherrer, Valerie
Faivre, Emilie
Baqi, Younis
Müller, Christa E.
Pimentel, José
Schiffmann, Serge N.
Buée, Luc
Bader, Michael
Outeiro, Tiago F.
Blum, David
Cunha, Rodrigo A.
Marie, Hélène
Pousinha, Paula
Lopes, Luísa V.
author_role author
author2 Ferreira, Diana
Batalha, Vânia
Marques-Morgado, Inês
Coelho, Joana E
Pereira, Pedro
Gomes, Rui
Pinto, Andreia
Carvalho, Sara
Canas, Paula M.
Cuvelier, Laetitia
Buée-Scherrer, Valerie
Faivre, Emilie
Baqi, Younis
Müller, Christa E.
Pimentel, José
Schiffmann, Serge N.
Buée, Luc
Bader, Michael
Outeiro, Tiago F.
Blum, David
Cunha, Rodrigo A.
Marie, Hélène
Pousinha, Paula
Lopes, Luísa V.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Temido Ferreira, Mariana
Ferreira, Diana
Batalha, Vânia
Marques-Morgado, Inês
Coelho, Joana E
Pereira, Pedro
Gomes, Rui
Pinto, Andreia
Carvalho, Sara
Canas, Paula M.
Cuvelier, Laetitia
Buée-Scherrer, Valerie
Faivre, Emilie
Baqi, Younis
Müller, Christa E.
Pimentel, José
Schiffmann, Serge N.
Buée, Luc
Bader, Michael
Outeiro, Tiago F.
Blum, David
Cunha, Rodrigo A.
Marie, Hélène
Pousinha, Paula
Lopes, Luísa V.
description © The Author(s) 2018. This article is published with open access. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2022-12-14T12:22:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/55389
url http://hdl.handle.net/10451/55389
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mol Psychiatry. 2020 Aug;25(8):1876-1900
1359-4184
10.1038/s41380-018-0110-9
1476-5578
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134612884029440