Biological activities of gedunin—A limonoid from the meliaceae family

Detalhes bibliográficos
Autor(a) principal: Braga, Teresa M.
Data de Publicação: 2020
Outros Autores: Rocha, Lídia, Chung, Tsz Yan, Ferraz Oliveira, Rita, Pinho, Cláudia, Oliveira, Ana Isabel, Morgado, Joaquim, Cruz, Agostinho
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/15363
Resumo: Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Several biological activities have been attributed to gedunin, including antibacterial, insecticidal, antimalarial, antiallergic, anti-inflammatory, anticancer, and neuroprotective effects. The discovery of gedunin as a heat shock protein (Hsp) inhibitor represented a very important landmark for its application as a biological therapeutic agent. The current study is a critical literature review based on the several biological activities so far described for gedunin, its therapeutic effect on some human diseases, and future directions of research for this natural compound.
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spelling Biological activities of gedunin—A limonoid from the meliaceae familyGeduninLimonoidMeliaceae familyBiological activityBioactive compoundGedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Several biological activities have been attributed to gedunin, including antibacterial, insecticidal, antimalarial, antiallergic, anti-inflammatory, anticancer, and neuroprotective effects. The discovery of gedunin as a heat shock protein (Hsp) inhibitor represented a very important landmark for its application as a biological therapeutic agent. The current study is a critical literature review based on the several biological activities so far described for gedunin, its therapeutic effect on some human diseases, and future directions of research for this natural compound.MDPIRepositório Científico do Instituto Politécnico do PortoBraga, Teresa M.Rocha, LídiaChung, Tsz YanFerraz Oliveira, RitaPinho, CláudiaOliveira, Ana IsabelMorgado, JoaquimCruz, Agostinho2020-01-23T17:20:57Z2020-012020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/15363porBraga, T. M., Rocha, L., Chung, T. Y., Oliveira, R. F., Pinho, C., Oliveira, A. I., Morgado, J., & Cruz, A. (2020). Biological activities of Gedunin—A limonoid from the Meliaceae family. Molecules, 25(3), Artigo 3. https://doi.org/10.3390/molecules2503049310.3390/molecules25030493info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-08-07T01:46:17Zoai:recipp.ipp.pt:10400.22/15363Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-08-07T01:46:17Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Biological activities of gedunin—A limonoid from the meliaceae family
title Biological activities of gedunin—A limonoid from the meliaceae family
spellingShingle Biological activities of gedunin—A limonoid from the meliaceae family
Braga, Teresa M.
Gedunin
Limonoid
Meliaceae family
Biological activity
Bioactive compound
title_short Biological activities of gedunin—A limonoid from the meliaceae family
title_full Biological activities of gedunin—A limonoid from the meliaceae family
title_fullStr Biological activities of gedunin—A limonoid from the meliaceae family
title_full_unstemmed Biological activities of gedunin—A limonoid from the meliaceae family
title_sort Biological activities of gedunin—A limonoid from the meliaceae family
author Braga, Teresa M.
author_facet Braga, Teresa M.
Rocha, Lídia
Chung, Tsz Yan
Ferraz Oliveira, Rita
Pinho, Cláudia
Oliveira, Ana Isabel
Morgado, Joaquim
Cruz, Agostinho
author_role author
author2 Rocha, Lídia
Chung, Tsz Yan
Ferraz Oliveira, Rita
Pinho, Cláudia
Oliveira, Ana Isabel
Morgado, Joaquim
Cruz, Agostinho
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Braga, Teresa M.
Rocha, Lídia
Chung, Tsz Yan
Ferraz Oliveira, Rita
Pinho, Cláudia
Oliveira, Ana Isabel
Morgado, Joaquim
Cruz, Agostinho
dc.subject.por.fl_str_mv Gedunin
Limonoid
Meliaceae family
Biological activity
Bioactive compound
topic Gedunin
Limonoid
Meliaceae family
Biological activity
Bioactive compound
description Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Several biological activities have been attributed to gedunin, including antibacterial, insecticidal, antimalarial, antiallergic, anti-inflammatory, anticancer, and neuroprotective effects. The discovery of gedunin as a heat shock protein (Hsp) inhibitor represented a very important landmark for its application as a biological therapeutic agent. The current study is a critical literature review based on the several biological activities so far described for gedunin, its therapeutic effect on some human diseases, and future directions of research for this natural compound.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-23T17:20:57Z
2020-01
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/15363
url http://hdl.handle.net/10400.22/15363
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Braga, T. M., Rocha, L., Chung, T. Y., Oliveira, R. F., Pinho, C., Oliveira, A. I., Morgado, J., & Cruz, A. (2020). Biological activities of Gedunin—A limonoid from the Meliaceae family. Molecules, 25(3), Artigo 3. https://doi.org/10.3390/molecules25030493
10.3390/molecules25030493
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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