Ventilatory defects and treatable traits in very elderly patients

Detalhes bibliográficos
Autor(a) principal: Gaspar-Marques, João
Data de Publicação: 2021
Outros Autores: Palmeiro, Teresa, Caires, Iolanda, Leiria Pinto, Paula, Neuparth, N, Carreiro-Martins, Pedro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/120530
Resumo: Funding: The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This study was supported by AstraZeneca – Projecto OLDER (CEDOC/2015/59) and Finnee Project (PTDC/CCI-BIO/29702/2017).
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spelling Ventilatory defects and treatable traits in very elderly patientsAgedcomorbiditylung diseasesobstructiverespiratory disordersSDG 3 - Good Health and Well-beingFunding: The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This study was supported by AstraZeneca – Projecto OLDER (CEDOC/2015/59) and Finnee Project (PTDC/CCI-BIO/29702/2017).Though the approach used to classify chronic respiratory diseases is changing to a treatable-traits (TT) approach, data regarding very elderly patients is lacking. The objectives of this study were to assess TT frequency in very elderly patients and to study the link between extrapulmonary TT and ventilatory defects. Individuals (≥75 years) residing in elderly care centres answered a standardised questionnaire, underwent spirometry, atopy and fractional exhaled nitric oxide assessments and had their blood pressure and peripheral pulse oximetry measured. Pulmonary, extrapulmonary and behavioural TT were evaluated. Outcome variables were an airflow limitation (post-bronchodilator z-score FEV1/FVC<-1.64) and a restrictive spirometry pattern (z-score FEV1/FVC ≥ +1.64 and z-score FVC<-1.64). Seventy-two percent of the individuals who took part in the study (n = 234) were women, and the median age of participants was 86 (IQR: 7.4). At least one pulmonary TT was identified in 105 (44.9%) individuals. The most frequent extrapulmonary TTs were: persistent systemic inflammation (47.0%), anaemia (34.4%), depression (32.5%) and obesity (27.4). Airflow limitation was exclusively associated with smoking (OR 5.03; 95% CI 1.56-16.22). A restrictive spirometry pattern was associated with cognitive impairment (OR: 3.89; 95% CI: 1.55-9.79). A high frequency of various TTs was found. The novel association between a restrictive spirometry pattern and cognitive impairment highlights the urgency of clinical research on this vulnerable age group.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNGaspar-Marques, JoãoPalmeiro, TeresaCaires, IolandaLeiria Pinto, PaulaNeuparth, NCarreiro-Martins, Pedro2021-07-05T22:17:55Z2021-05-012021-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/120530eng0036-8504PURE: 29567433https://doi.org/10.1177/00368504211013171info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:54:23Zoai:run.unl.pt:10362/120530Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:54:23Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Ventilatory defects and treatable traits in very elderly patients
title Ventilatory defects and treatable traits in very elderly patients
spellingShingle Ventilatory defects and treatable traits in very elderly patients
Gaspar-Marques, João
Aged
comorbidity
lung diseases
obstructive
respiratory disorders
SDG 3 - Good Health and Well-being
title_short Ventilatory defects and treatable traits in very elderly patients
title_full Ventilatory defects and treatable traits in very elderly patients
title_fullStr Ventilatory defects and treatable traits in very elderly patients
title_full_unstemmed Ventilatory defects and treatable traits in very elderly patients
title_sort Ventilatory defects and treatable traits in very elderly patients
author Gaspar-Marques, João
author_facet Gaspar-Marques, João
Palmeiro, Teresa
Caires, Iolanda
Leiria Pinto, Paula
Neuparth, N
Carreiro-Martins, Pedro
author_role author
author2 Palmeiro, Teresa
Caires, Iolanda
Leiria Pinto, Paula
Neuparth, N
Carreiro-Martins, Pedro
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
RUN
dc.contributor.author.fl_str_mv Gaspar-Marques, João
Palmeiro, Teresa
Caires, Iolanda
Leiria Pinto, Paula
Neuparth, N
Carreiro-Martins, Pedro
dc.subject.por.fl_str_mv Aged
comorbidity
lung diseases
obstructive
respiratory disorders
SDG 3 - Good Health and Well-being
topic Aged
comorbidity
lung diseases
obstructive
respiratory disorders
SDG 3 - Good Health and Well-being
description Funding: The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This study was supported by AstraZeneca – Projecto OLDER (CEDOC/2015/59) and Finnee Project (PTDC/CCI-BIO/29702/2017).
publishDate 2021
dc.date.none.fl_str_mv 2021-07-05T22:17:55Z
2021-05-01
2021-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/120530
url http://hdl.handle.net/10362/120530
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0036-8504
PURE: 29567433
https://doi.org/10.1177/00368504211013171
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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