The effect of angiography with disodium fluorescein on the hemorheologic parameters of diabetics.
Autor(a) principal: | |
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Data de Publicação: | 1996 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2628 |
Resumo: | Chorioretinal angiography with fluorescein is an auxiliary method widely used in Ophthalmology which enables us to study the blood/humour and blood/retina/choroid interface. The presence of a strange compound in circulation may interfere with blood flow homeostasis. With the aim of studying fluorescein influence in blood rheology, blood samples were drawn before, immediately after and 30 minutes after fluorescein bolus injection; from 10 patients with diabetes mellitus, with or without retinopathy, blood fluidity (hematocrit, erythrocyte aggregation and whole blood viscosity) and erythrocyte membrane functional properties were determined. After fluorescein injection there was erythrocyte hyperaggregation (37.7%, p = 0.004), was detected, hemoglobin concentration (p = 0.039) and hematocrit (p = 0.013) decrease, and a double time increase of methemoglobin concentration (p < 0.001) the erythrocyte membrane hydrophobic region became more rigid (p = 0.016). All these abnormalities normalized after 30 minutes. In conclusion, fluorescein angiography interferes acutely with the hemorheological parameters of patients with diabetes mellitus, with erythrocyte hyperaggregation which could interfere with the microcirculation of these patients. |
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The effect of angiography with disodium fluorescein on the hemorheologic parameters of diabetics.Estudo da influência da angiografia com fluoresceína bissódica nos parâmetros hemorreológicos de doentes com diabetes mellitus.Chorioretinal angiography with fluorescein is an auxiliary method widely used in Ophthalmology which enables us to study the blood/humour and blood/retina/choroid interface. The presence of a strange compound in circulation may interfere with blood flow homeostasis. With the aim of studying fluorescein influence in blood rheology, blood samples were drawn before, immediately after and 30 minutes after fluorescein bolus injection; from 10 patients with diabetes mellitus, with or without retinopathy, blood fluidity (hematocrit, erythrocyte aggregation and whole blood viscosity) and erythrocyte membrane functional properties were determined. After fluorescein injection there was erythrocyte hyperaggregation (37.7%, p = 0.004), was detected, hemoglobin concentration (p = 0.039) and hematocrit (p = 0.013) decrease, and a double time increase of methemoglobin concentration (p < 0.001) the erythrocyte membrane hydrophobic region became more rigid (p = 0.016). All these abnormalities normalized after 30 minutes. In conclusion, fluorescein angiography interferes acutely with the hemorheological parameters of patients with diabetes mellitus, with erythrocyte hyperaggregation which could interfere with the microcirculation of these patients.Chorioretinal angiography with fluorescein is an auxiliary method widely used in Ophthalmology which enables us to study the blood/humour and blood/retina/choroid interface. The presence of a strange compound in circulation may interfere with blood flow homeostasis. With the aim of studying fluorescein influence in blood rheology, blood samples were drawn before, immediately after and 30 minutes after fluorescein bolus injection; from 10 patients with diabetes mellitus, with or without retinopathy, blood fluidity (hematocrit, erythrocyte aggregation and whole blood viscosity) and erythrocyte membrane functional properties were determined. After fluorescein injection there was erythrocyte hyperaggregation (37.7%, p = 0.004), was detected, hemoglobin concentration (p = 0.039) and hematocrit (p = 0.013) decrease, and a double time increase of methemoglobin concentration (p < 0.001) the erythrocyte membrane hydrophobic region became more rigid (p = 0.016). All these abnormalities normalized after 30 minutes. In conclusion, fluorescein angiography interferes acutely with the hemorheological parameters of patients with diabetes mellitus, with erythrocyte hyperaggregation which could interfere with the microcirculation of these patients.Ordem dos Médicos1996-12-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2628oai:ojs.www.actamedicaportuguesa.com:article/2628Acta Médica Portuguesa; Vol. 9 No. 10-12 (1996): Outubro-Dezembro; 303-7Acta Médica Portuguesa; Vol. 9 N.º 10-12 (1996): Outubro-Dezembro; 303-71646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2628https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2628/2040Sargento, LZabala, LGomes, TSaldanha, CMartins-Silva, JSouza-Ramalho, Pinfo:eu-repo/semantics/openAccess2022-12-20T11:00:53Zoai:ojs.www.actamedicaportuguesa.com:article/2628Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:17:52.238863Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The effect of angiography with disodium fluorescein on the hemorheologic parameters of diabetics. Estudo da influência da angiografia com fluoresceína bissódica nos parâmetros hemorreológicos de doentes com diabetes mellitus. |
title |
The effect of angiography with disodium fluorescein on the hemorheologic parameters of diabetics. |
spellingShingle |
The effect of angiography with disodium fluorescein on the hemorheologic parameters of diabetics. Sargento, L |
title_short |
The effect of angiography with disodium fluorescein on the hemorheologic parameters of diabetics. |
title_full |
The effect of angiography with disodium fluorescein on the hemorheologic parameters of diabetics. |
title_fullStr |
The effect of angiography with disodium fluorescein on the hemorheologic parameters of diabetics. |
title_full_unstemmed |
The effect of angiography with disodium fluorescein on the hemorheologic parameters of diabetics. |
title_sort |
The effect of angiography with disodium fluorescein on the hemorheologic parameters of diabetics. |
author |
Sargento, L |
author_facet |
Sargento, L Zabala, L Gomes, T Saldanha, C Martins-Silva, J Souza-Ramalho, P |
author_role |
author |
author2 |
Zabala, L Gomes, T Saldanha, C Martins-Silva, J Souza-Ramalho, P |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Sargento, L Zabala, L Gomes, T Saldanha, C Martins-Silva, J Souza-Ramalho, P |
description |
Chorioretinal angiography with fluorescein is an auxiliary method widely used in Ophthalmology which enables us to study the blood/humour and blood/retina/choroid interface. The presence of a strange compound in circulation may interfere with blood flow homeostasis. With the aim of studying fluorescein influence in blood rheology, blood samples were drawn before, immediately after and 30 minutes after fluorescein bolus injection; from 10 patients with diabetes mellitus, with or without retinopathy, blood fluidity (hematocrit, erythrocyte aggregation and whole blood viscosity) and erythrocyte membrane functional properties were determined. After fluorescein injection there was erythrocyte hyperaggregation (37.7%, p = 0.004), was detected, hemoglobin concentration (p = 0.039) and hematocrit (p = 0.013) decrease, and a double time increase of methemoglobin concentration (p < 0.001) the erythrocyte membrane hydrophobic region became more rigid (p = 0.016). All these abnormalities normalized after 30 minutes. In conclusion, fluorescein angiography interferes acutely with the hemorheological parameters of patients with diabetes mellitus, with erythrocyte hyperaggregation which could interfere with the microcirculation of these patients. |
publishDate |
1996 |
dc.date.none.fl_str_mv |
1996-12-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2628 oai:ojs.www.actamedicaportuguesa.com:article/2628 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2628 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/2628 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2628 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2628/2040 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 9 No. 10-12 (1996): Outubro-Dezembro; 303-7 Acta Médica Portuguesa; Vol. 9 N.º 10-12 (1996): Outubro-Dezembro; 303-7 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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