Breaking the classics: next-generation biosensors for the isolation, profiling and detection of extracellular vesicles
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/1822/75946 |
Resumo: | Available online 28 January 2022. |
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Breaking the classics: next-generation biosensors for the isolation, profiling and detection of extracellular vesiclesExtracellular vesiclesIntercellular communicationBiosensorsNanotechnologyHealth monitoringAvailable online 28 January 2022.Extracellular vesicles (EVs) contain biomarkers that may represent a paradigm shift in timely disease diagnosis and personalized therapeutic approaches. Despite tremendous progress in this field, the considerable complexity and heterogeneity of EVs, combined with hurdles in isolation and accurate characterization, have delayed their envisioned clinical translation. At the same time, emerging biosensor technologies are trying to overcome the limitations and provide new momentum to EVs research. In this review, the focus is given on the variety of novel approaches to improve the capture of EVs of interest from a myriad of sample types in terms of yield, purity, sensitivity, and specificity. These biosensing devices also contribute to the understanding of the content of EVs in correlation with their function. Given the pivotal role of EVs uncovered to date and the recent technological advances discussed herein, nanosensing platforms offer low-cost, fast, simple, and accurate methods that are likely to help gain more insight into the biology of EVs. Moreover, the prospect of identifying new roles and patterns will reinforce the importance of EVs and intercellular communication in health status.The authors gratefully acknowledge funding from the European Commission trough the project MindGAP (FET-Open/H2020/GA829040). The authors RV, YCG and ARC also acknowledge Fundação para a Ciência e Tecnologia their PhD grants (2020.09673.BD, SFRH/BD/145590/2019, and SFRH/BD/130107/2017, respectively).info:eu-repo/semantics/publishedVersionElsevier B.V.Universidade do MinhoVaz, RaquelSerrano, Verónica M.Castaño-Guerrero, YuselisCardoso, Ana R.Frasco, Manuela FariaSales, M. Goreti F.2022-052022-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/75946engVaz, Raquel; Serrano, Verónica; Guerrero, Yuselis; Cardoso, Rita; Frasco, Manuela; Sales, M. G. F., Breaking the classics: Next-generation biosensors for the isolation, profiling and detection of extracellular vesicles. Biosensors and Bioelectronics: X, 10(100115), 20222590-137010.1016/j.biosx.2022.100115https://www.sciencedirect.com/journal/biosensors-and-bioelectronics-xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:33:55Zoai:repositorium.sdum.uminho.pt:1822/75946Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:29:31.168550Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Breaking the classics: next-generation biosensors for the isolation, profiling and detection of extracellular vesicles |
| title |
Breaking the classics: next-generation biosensors for the isolation, profiling and detection of extracellular vesicles |
| spellingShingle |
Breaking the classics: next-generation biosensors for the isolation, profiling and detection of extracellular vesicles Vaz, Raquel Extracellular vesicles Intercellular communication Biosensors Nanotechnology Health monitoring |
| title_short |
Breaking the classics: next-generation biosensors for the isolation, profiling and detection of extracellular vesicles |
| title_full |
Breaking the classics: next-generation biosensors for the isolation, profiling and detection of extracellular vesicles |
| title_fullStr |
Breaking the classics: next-generation biosensors for the isolation, profiling and detection of extracellular vesicles |
| title_full_unstemmed |
Breaking the classics: next-generation biosensors for the isolation, profiling and detection of extracellular vesicles |
| title_sort |
Breaking the classics: next-generation biosensors for the isolation, profiling and detection of extracellular vesicles |
| author |
Vaz, Raquel |
| author_facet |
Vaz, Raquel Serrano, Verónica M. Castaño-Guerrero, Yuselis Cardoso, Ana R. Frasco, Manuela Faria Sales, M. Goreti F. |
| author_role |
author |
| author2 |
Serrano, Verónica M. Castaño-Guerrero, Yuselis Cardoso, Ana R. Frasco, Manuela Faria Sales, M. Goreti F. |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Vaz, Raquel Serrano, Verónica M. Castaño-Guerrero, Yuselis Cardoso, Ana R. Frasco, Manuela Faria Sales, M. Goreti F. |
| dc.subject.por.fl_str_mv |
Extracellular vesicles Intercellular communication Biosensors Nanotechnology Health monitoring |
| topic |
Extracellular vesicles Intercellular communication Biosensors Nanotechnology Health monitoring |
| description |
Available online 28 January 2022. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-05 2022-05-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/75946 |
| url |
http://hdl.handle.net/1822/75946 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Vaz, Raquel; Serrano, Verónica; Guerrero, Yuselis; Cardoso, Rita; Frasco, Manuela; Sales, M. G. F., Breaking the classics: Next-generation biosensors for the isolation, profiling and detection of extracellular vesicles. Biosensors and Bioelectronics: X, 10(100115), 2022 2590-1370 10.1016/j.biosx.2022.100115 https://www.sciencedirect.com/journal/biosensors-and-bioelectronics-x |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier B.V. |
| publisher.none.fl_str_mv |
Elsevier B.V. |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132795288682496 |