P-cadherin expression in glandular lesions of the uterine cervix detected by liquid-based cytology

• Autor(a) principal: Longatto Filho, Adhemar
• Data de Publicação: 2005
• Outros Autores: Albergaria, André, Paredes, Joana, Moreira, M. A. R., Milanezi, Fernanda, Schmitt, Fernando C.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/1822/2933
• topic: P-cadherin; Uterine cervix; Glandular lesions; Liquid-based cytology; Science & Technology

Objective: To study P-cadherin aberrant expression as a possible marker for cervical adenocarcinomas in cytological samples. Methods: We studied P-cadherin immunoexpression in liquid-based cervical cytology samples of biopsy-proven cervical lesions. Results: We found a statistically significant correlation between P-cadherin expression and a cytological diagnosis of malignancy, either glandular or squamous (P < 0.0001). Twenty-two of 33 malignant cases showed P-cadherin membrane staining. None of the 30 benign cases tested showed membrane staining, but three of them displayed an aberrant nuclear P-cadherin expression. Conclusions: We concluded that P-cadherin can be used to discriminate between malignant and benign cervical cytological specimens, but not to discriminate glandular from squamous lesions.