Essential Trace Elements Status in Portuguese Pregnant Women and Their Association with Maternal and Neonatal Outcomes

• Autor(a) principal: Bracchi, Isabella
• Data de Publicação: 2023
• Outros Autores: Guimarães, Juliana, Rodrigues, Catarina, Azevedo, Rui, Coelho, Cláudia Matta, Pinheiro, Cátia, Morais, Juliana, Barreiros-Mota, Inês, Fernandes, Virgínia Cruz, Delerue-Matos, Cristina, Pinto, Edgar, Moreira-Rosário, André, de Azevedo, Luís Filipe Ribeiro, Dias, Cláudia Camila, Lima, Jorge, Sapinho, Inês, Ramalho, Carla, Calhau, Conceição, Leite, João Costa, Almeida, Agostinho, Pestana, Diogo, Keating, Elisa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10362/160681
• topic: essential trace elements; neonatal anthropometry; neonatal outcomes; pre-eclampsia; pregnancy; pregnancy complications; SDG 3 - Good Health and Well-being

Cobalt (Co), copper (Cu), manganese (Mn), molybdenum (Mo), and zinc (Zn) are essential trace elements (ETEs) and important cofactors for intermediary metabolism or redox balance. These ETEs are crucial during pregnancy, their role on specific pregnancy outcomes is largely unknown. This prospective study (#NCT04010708) aimed to assess urinary levels of these ETEs in pregnancy and to evaluate their association with pregnancy outcomes. First trimester pregnant women of Porto and Lisbon provided a random spot urine sample, and sociodemographic and lifestyle data. Clinical data were obtained from clinical records. Urinary ETEs were quantified by inductively coupled plasma mass spectrometry (ICP-MS). A total of 635 mother:child pairs were included. Having urinary Zn levels above the 50th percentile (P50) was an independent risk factor for pre-eclampsia (PE) (aOR [95% CI]: 5.350 [1.044-27.423], p = 0.044). Urinary Zn levels above the P50 decreased the risk of small for gestational age (SGA) birth head circumference (aOR [95% CI]: 0.315 [0.113-0.883], p = 0.028), but it increased the risk SGA length (aOR [95% CI]: 2.531 [1.057-6.062], p = 0.037). This study may provide valuable information for public health policies related to prenatal nutrition, while informing future efforts to de-fine urinary reference intervals for ETEs in pregnant women.