Pseudoboehmite as a drug delivery system for acyclovir

• Autor(a) principal: Peres, RM
• Data de Publicação: 2021
• Outros Autores: Sousa, JML, Oliveira, MO, Rossi, MV, Oliveira, RR, Lima, NB, Bernussi, A, Warzywoda, J, Sarmento, B, Munhoz, AH
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://hdl.handle.net/10216/153741
• topic: Acyclovir / administration & dosage; Acyclovir / blood; Acyclovir / pharmacokinetics; Administration, Oral; Aluminum Hydroxide / chemistry; Aluminum Hydroxide / pharmacology; Aluminum Oxide / chemistry; Aluminum Oxide / pharmacology; Animals; Antiviral Agents / administration & dosage; Antiviral Agents / blood; Antiviral Agents / pharmacokinetics; Biological Availability; Caco-2 Cells; Cell Survival / drug effects; Drug Delivery Systems / methods; Drug Liberation; Herpes Simplex / drug therapy; Herpes Simplex / virology; Humans; Models, Animal; Nanogels / chemistry; Rats; Rats, Wistar; Simplexvirus / drug effects

Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem of the oral bioavailability of acyclovir is limited because of the low permeability across the gastrointestinal membrane. The use of nanoparticles of pseudoboehmite as a drug delivery system in vitro assays is a promising approach to further the permeability of acyclovir release. Here we report the synthesis of high purity pseudoboehmite from aluminium nitrate and ammonium hydroxide containing nanoparticles, using the sol–gel method, as a drug delivery system to improve the systemic bioavailability of acyclovir. The presence of pseudoboehmite nanoparticles were verified by infrared spectroscopy, transmission electron microscopy, and X-ray diffraction techniques. In vivo tests were performed with Wistar rats to compare the release of acyclovir, with and without the addition of pseudoboehmite. The administration of acyclovir with the addition of pseudoboehmite increased the drug content by 4.6 times in the plasma of Wistar rats after 4 h administration. We determined that the toxicity of pseudoboehmite is low up to 10 mg/mL, in gel and the dried pseudoboehmite nanoparticles.