Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/11396 |
Resumo: | The pivotal mechanisms that govern the correct patterning and regionalization of the distinct areas of the mammalian CNS are driven by key molecules that emanate from the so-called secondary organizers at neural plate and tube stages. FGF8 is the candidate morphogenetic molecule to pattern the mesencephalon and rhombencephalon in the isthmic organizer (IsO). Recognizable relevance has been given to the intracellular pathways by which Fgf8 is regulated and modulated. In chick limb bud development, a dual mitogen-activated protein kinase phosphatase-3 (Mkp3) plays a role as a negative feedback modulator of Fgf8 signaling. We have investigated the role of Mkp3 and its functional relationship with the Fgf8 signaling pathway in the mouse IsO using gene transfer microelectroporation assays and protein-soaked bead experiments. Here, we demonstrate that MKP3 has a negative feedback action on the MAPK/ERK-mediated FGF8 pathway in the mouse neuroepithelium. (C) 2004 Elsevier Inc. All rights reserved. |
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Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizerMap-kinase phosphataseFibroblast growth-factorsMid-hindbrain organizerTyrosine kinasePhosphatidylinositol 3-kinaseMid/Hindbrain organizerMouse embryogenesisInt-1 ProtooncogeneFactor receptorRetinoic acidThe pivotal mechanisms that govern the correct patterning and regionalization of the distinct areas of the mammalian CNS are driven by key molecules that emanate from the so-called secondary organizers at neural plate and tube stages. FGF8 is the candidate morphogenetic molecule to pattern the mesencephalon and rhombencephalon in the isthmic organizer (IsO). Recognizable relevance has been given to the intracellular pathways by which Fgf8 is regulated and modulated. In chick limb bud development, a dual mitogen-activated protein kinase phosphatase-3 (Mkp3) plays a role as a negative feedback modulator of Fgf8 signaling. We have investigated the role of Mkp3 and its functional relationship with the Fgf8 signaling pathway in the mouse IsO using gene transfer microelectroporation assays and protein-soaked bead experiments. Here, we demonstrate that MKP3 has a negative feedback action on the MAPK/ERK-mediated FGF8 pathway in the mouse neuroepithelium. (C) 2004 Elsevier Inc. All rights reserved.Academic Press Inc Elsevier ScienceSapientiaEchevarria, DMartinez, SMarques, SLucas-Teixeira, VBelo, JA2018-12-07T14:53:12Z2005-012005-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/11396eng0012-160610.1016/j.ydbio.2004.09.011info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:23:12Zoai:sapientia.ualg.pt:10400.1/11396Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:02:54.809770Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer |
title |
Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer |
spellingShingle |
Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer Echevarria, D Map-kinase phosphatase Fibroblast growth-factors Mid-hindbrain organizer Tyrosine kinase Phosphatidylinositol 3-kinase Mid/Hindbrain organizer Mouse embryogenesis Int-1 Protooncogene Factor receptor Retinoic acid |
title_short |
Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer |
title_full |
Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer |
title_fullStr |
Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer |
title_full_unstemmed |
Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer |
title_sort |
Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer |
author |
Echevarria, D |
author_facet |
Echevarria, D Martinez, S Marques, S Lucas-Teixeira, V Belo, JA |
author_role |
author |
author2 |
Martinez, S Marques, S Lucas-Teixeira, V Belo, JA |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Echevarria, D Martinez, S Marques, S Lucas-Teixeira, V Belo, JA |
dc.subject.por.fl_str_mv |
Map-kinase phosphatase Fibroblast growth-factors Mid-hindbrain organizer Tyrosine kinase Phosphatidylinositol 3-kinase Mid/Hindbrain organizer Mouse embryogenesis Int-1 Protooncogene Factor receptor Retinoic acid |
topic |
Map-kinase phosphatase Fibroblast growth-factors Mid-hindbrain organizer Tyrosine kinase Phosphatidylinositol 3-kinase Mid/Hindbrain organizer Mouse embryogenesis Int-1 Protooncogene Factor receptor Retinoic acid |
description |
The pivotal mechanisms that govern the correct patterning and regionalization of the distinct areas of the mammalian CNS are driven by key molecules that emanate from the so-called secondary organizers at neural plate and tube stages. FGF8 is the candidate morphogenetic molecule to pattern the mesencephalon and rhombencephalon in the isthmic organizer (IsO). Recognizable relevance has been given to the intracellular pathways by which Fgf8 is regulated and modulated. In chick limb bud development, a dual mitogen-activated protein kinase phosphatase-3 (Mkp3) plays a role as a negative feedback modulator of Fgf8 signaling. We have investigated the role of Mkp3 and its functional relationship with the Fgf8 signaling pathway in the mouse IsO using gene transfer microelectroporation assays and protein-soaked bead experiments. Here, we demonstrate that MKP3 has a negative feedback action on the MAPK/ERK-mediated FGF8 pathway in the mouse neuroepithelium. (C) 2004 Elsevier Inc. All rights reserved. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-01 2005-01-01T00:00:00Z 2018-12-07T14:53:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/11396 |
url |
http://hdl.handle.net/10400.1/11396 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0012-1606 10.1016/j.ydbio.2004.09.011 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Academic Press Inc Elsevier Science |
publisher.none.fl_str_mv |
Academic Press Inc Elsevier Science |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133263428583424 |