Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical Application

Detalhes bibliográficos
Autor(a) principal: Canberk, S
Data de Publicação: 2021
Outros Autores: Lima, AR, Pinto, M, Soares, P, Máximo, V
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/152521
Resumo: It has been widely described that cancer genomes have frequent alterations to the epigenome, including epigenetic silencing of various tumor suppressor genes with functions in almost all cancer-relevant signalling pathways, such as apoptosis, cell proliferation, cell migration and DNA repair. Epigenetic alterations comprise DNA methylation, histone modification, and microRNAs dysregulated expression and they play a significant role in the differentiation and proliferation properties of TC. In this review, our group assessed the published evidence on the tumorigenic role of epigenomics in Hurthle cell neoplasms (HCN), highlighting the yet limited, heteregeneous and non-validated data preventing its current use in clinical practice, despite the well developed assessment techniques available. The identified evidence gaps call for a joint endeavour by the medical community towards a deeper and more systematic study of HCN, aiming at defining epigenetic markers in early diagnose, allowing for accurate stratification of maligancy and disease risk and for effective systemic treatment.
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spelling Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical ApplicationEpigenetics analysisEpigenomicsHürthle cell carcinomaHürthle cell tumorsHürthle cellsMitochondriaOncocytic cellsThyroid tumorsIt has been widely described that cancer genomes have frequent alterations to the epigenome, including epigenetic silencing of various tumor suppressor genes with functions in almost all cancer-relevant signalling pathways, such as apoptosis, cell proliferation, cell migration and DNA repair. Epigenetic alterations comprise DNA methylation, histone modification, and microRNAs dysregulated expression and they play a significant role in the differentiation and proliferation properties of TC. In this review, our group assessed the published evidence on the tumorigenic role of epigenomics in Hurthle cell neoplasms (HCN), highlighting the yet limited, heteregeneous and non-validated data preventing its current use in clinical practice, despite the well developed assessment techniques available. The identified evidence gaps call for a joint endeavour by the medical community towards a deeper and more systematic study of HCN, aiming at defining epigenetic markers in early diagnose, allowing for accurate stratification of maligancy and disease risk and for effective systemic treatment.Frontiers Media20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/152521eng1664-239210.3389/fendo.2021.674666Canberk, SLima, ARPinto, MSoares, PMáximo, Vinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:16:06Zoai:repositorio-aberto.up.pt:10216/152521Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:19:22.917192Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical Application
title Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical Application
spellingShingle Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical Application
Canberk, S
Epigenetics analysis
Epigenomics
Hürthle cell carcinoma
Hürthle cell tumors
Hürthle cells
Mitochondria
Oncocytic cells
Thyroid tumors
title_short Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical Application
title_full Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical Application
title_fullStr Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical Application
title_full_unstemmed Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical Application
title_sort Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical Application
author Canberk, S
author_facet Canberk, S
Lima, AR
Pinto, M
Soares, P
Máximo, V
author_role author
author2 Lima, AR
Pinto, M
Soares, P
Máximo, V
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Canberk, S
Lima, AR
Pinto, M
Soares, P
Máximo, V
dc.subject.por.fl_str_mv Epigenetics analysis
Epigenomics
Hürthle cell carcinoma
Hürthle cell tumors
Hürthle cells
Mitochondria
Oncocytic cells
Thyroid tumors
topic Epigenetics analysis
Epigenomics
Hürthle cell carcinoma
Hürthle cell tumors
Hürthle cells
Mitochondria
Oncocytic cells
Thyroid tumors
description It has been widely described that cancer genomes have frequent alterations to the epigenome, including epigenetic silencing of various tumor suppressor genes with functions in almost all cancer-relevant signalling pathways, such as apoptosis, cell proliferation, cell migration and DNA repair. Epigenetic alterations comprise DNA methylation, histone modification, and microRNAs dysregulated expression and they play a significant role in the differentiation and proliferation properties of TC. In this review, our group assessed the published evidence on the tumorigenic role of epigenomics in Hurthle cell neoplasms (HCN), highlighting the yet limited, heteregeneous and non-validated data preventing its current use in clinical practice, despite the well developed assessment techniques available. The identified evidence gaps call for a joint endeavour by the medical community towards a deeper and more systematic study of HCN, aiming at defining epigenetic markers in early diagnose, allowing for accurate stratification of maligancy and disease risk and for effective systemic treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/152521
url https://hdl.handle.net/10216/152521
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1664-2392
10.3389/fendo.2021.674666
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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