Micro-RNA Analysis in Pulmonary Arterial Hypertension: Current Knowledge and Challenges

• Autor(a) principal: Santos-Ferreira, Cátia A.
• Data de Publicação: 2020
• Outros Autores: Abreu, Mónica T., Marques, Carla I., Gonçalves, Lino M., Baptista, Rui, Girão, Henrique M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/101257; https://doi.org/10.1016/j.jacbts.2020.07.008
• topic: animal model; micro-RNA; microarray; pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a rare, chronic disease of the pulmonary vasculature that is associated with poor outcomes. Its pathogenesis is multifactorial and includes micro-RNA (miRNA) deregulation. The understanding of the role of miRNAs in PAH is expanding quickly, and it is increasingly difficult to identify which miRNAs have the highest translational potential. This review summarizes the current knowledge of miRNA expression in PAH, discusses the challenges in miRNA analysis and interpretation, and highlights 4 promising miRNAs in this field (miR-29, miR-124, miR-140, and miR-204).