Congenital Cytomegalovirus Infection in Twin Pregnancy
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/4695 |
Resumo: | Cytomegalovirus (CMV) infection is one of the preeminent congenital viral infections, and despite its potential morbidity, uncertainty about its physiopathology, prevention and treatment remains until now. We report a case of a dichorionic and diamniotic twin pregnancy in which only one of the fetus had signs of being affected. The first twin had prenatal diagnosis of intrauterine growth restriction and hyperechogenic bowel, attributable to CMV infection, while there was no evidence of infection of the second one. Prenatal treatment was done with maternal administration of valacyclovir and postnatal treatment of the infected newborn with oral valganciclovir with normal neurodevelopment assessment at 12 months corrected age. In this case, maternal CMV infection was not equally transmitted to both fetuses, suggesting that there may be intrinsic fetal and placental factors influencing both transmission and the clinical features of the infection. |
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Congenital Cytomegalovirus Infection in Twin PregnancyCytomegalovirus Infections* / diagnosisCytomegalovirus Infections* / drug therapyFemaleInfant, NewbornInfectious Disease Transmission, VerticalPlacentaPregnancyPregnancy Complications, Infectious* / diagnosisPregnancy Complications, Infectious* / drug therapyPregnancy, TwinHDE PEDMAC OBSMAC UCI NEOCytomegalovirus (CMV) infection is one of the preeminent congenital viral infections, and despite its potential morbidity, uncertainty about its physiopathology, prevention and treatment remains until now. We report a case of a dichorionic and diamniotic twin pregnancy in which only one of the fetus had signs of being affected. The first twin had prenatal diagnosis of intrauterine growth restriction and hyperechogenic bowel, attributable to CMV infection, while there was no evidence of infection of the second one. Prenatal treatment was done with maternal administration of valacyclovir and postnatal treatment of the infected newborn with oral valganciclovir with normal neurodevelopment assessment at 12 months corrected age. In this case, maternal CMV infection was not equally transmitted to both fetuses, suggesting that there may be intrinsic fetal and placental factors influencing both transmission and the clinical features of the infection.BMJRepositório do Centro Hospitalar Universitário de Lisboa Central, EPECarvalho, AASilva, CBMartins, MLCassiano Santos, GCassiano2023-09-11T12:31:35Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4695engBMJ Case Rep . 2021 Jul 12;14(7):e24271210.1136/bcr-2021-242712info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-17T06:26:51Zoai:repositorio.chlc.min-saude.pt:10400.17/4695Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:29:29.474355Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Congenital Cytomegalovirus Infection in Twin Pregnancy |
title |
Congenital Cytomegalovirus Infection in Twin Pregnancy |
spellingShingle |
Congenital Cytomegalovirus Infection in Twin Pregnancy Carvalho, AA Cytomegalovirus Infections* / diagnosis Cytomegalovirus Infections* / drug therapy Female Infant, Newborn Infectious Disease Transmission, Vertical Placenta Pregnancy Pregnancy Complications, Infectious* / diagnosis Pregnancy Complications, Infectious* / drug therapy Pregnancy, Twin HDE PED MAC OBS MAC UCI NEO |
title_short |
Congenital Cytomegalovirus Infection in Twin Pregnancy |
title_full |
Congenital Cytomegalovirus Infection in Twin Pregnancy |
title_fullStr |
Congenital Cytomegalovirus Infection in Twin Pregnancy |
title_full_unstemmed |
Congenital Cytomegalovirus Infection in Twin Pregnancy |
title_sort |
Congenital Cytomegalovirus Infection in Twin Pregnancy |
author |
Carvalho, AA |
author_facet |
Carvalho, AA Silva, CB Martins, ML Cassiano Santos, GCassiano |
author_role |
author |
author2 |
Silva, CB Martins, ML Cassiano Santos, GCassiano |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Carvalho, AA Silva, CB Martins, ML Cassiano Santos, GCassiano |
dc.subject.por.fl_str_mv |
Cytomegalovirus Infections* / diagnosis Cytomegalovirus Infections* / drug therapy Female Infant, Newborn Infectious Disease Transmission, Vertical Placenta Pregnancy Pregnancy Complications, Infectious* / diagnosis Pregnancy Complications, Infectious* / drug therapy Pregnancy, Twin HDE PED MAC OBS MAC UCI NEO |
topic |
Cytomegalovirus Infections* / diagnosis Cytomegalovirus Infections* / drug therapy Female Infant, Newborn Infectious Disease Transmission, Vertical Placenta Pregnancy Pregnancy Complications, Infectious* / diagnosis Pregnancy Complications, Infectious* / drug therapy Pregnancy, Twin HDE PED MAC OBS MAC UCI NEO |
description |
Cytomegalovirus (CMV) infection is one of the preeminent congenital viral infections, and despite its potential morbidity, uncertainty about its physiopathology, prevention and treatment remains until now. We report a case of a dichorionic and diamniotic twin pregnancy in which only one of the fetus had signs of being affected. The first twin had prenatal diagnosis of intrauterine growth restriction and hyperechogenic bowel, attributable to CMV infection, while there was no evidence of infection of the second one. Prenatal treatment was done with maternal administration of valacyclovir and postnatal treatment of the infected newborn with oral valganciclovir with normal neurodevelopment assessment at 12 months corrected age. In this case, maternal CMV infection was not equally transmitted to both fetuses, suggesting that there may be intrinsic fetal and placental factors influencing both transmission and the clinical features of the infection. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2023-09-11T12:31:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/4695 |
url |
http://hdl.handle.net/10400.17/4695 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BMJ Case Rep . 2021 Jul 12;14(7):e242712 10.1136/bcr-2021-242712 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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BMJ |
publisher.none.fl_str_mv |
BMJ |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133562591510528 |