Halogen atom effect on photophysical and photodynamic characteristics of derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin

Detalhes bibliográficos
Autor(a) principal: Serra, A. C.
Data de Publicação: 2008
Outros Autores: Pineiro, M., Gonsalves, A. M. d'A. Rocha, Abrantes, M., Laranjo, M., Santos, A. C., Botelho, M. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/5000
https://doi.org/10.1016/j.jphotobiol.2008.04.006
Resumo: Brominated and iodinated derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin were synthesised directly from the corresponding aldehydes. Photophysical and photochemical properties, singlet oxygen formation quantum yields, photobleaching and log P were measured. Cellular uptake measurements and cytotoxicity assays on WiDr and A375 tumour cell lines were performed. 5,10,15,20-Tetrakis(2-bromo-5-hydroxyphenyl)porphyrin showed the best cytotoxicity with values of IC50 of 113 nM over WiDr cells and 52 nM over A375 cells.
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spelling Halogen atom effect on photophysical and photodynamic characteristics of derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrinHalogenated porphyrinsPhotodynamic therapyHeavy atom effectBrominated and iodinated derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin were synthesised directly from the corresponding aldehydes. Photophysical and photochemical properties, singlet oxygen formation quantum yields, photobleaching and log P were measured. Cellular uptake measurements and cytotoxicity assays on WiDr and A375 tumour cell lines were performed. 5,10,15,20-Tetrakis(2-bromo-5-hydroxyphenyl)porphyrin showed the best cytotoxicity with values of IC50 of 113 nM over WiDr cells and 52 nM over A375 cells.http://www.sciencedirect.com/science/article/B6TH0-4SCKRV7-2/1/f341bf72f1ad4338d46c1c71eadc64e32008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/5000http://hdl.handle.net/10316/5000https://doi.org/10.1016/j.jphotobiol.2008.04.006engJournal of Photochemistry and Photobiology B: Biology. 92:1 (2008) 59-65Serra, A. C.Pineiro, M.Gonsalves, A. M. d'A. RochaAbrantes, M.Laranjo, M.Santos, A. C.Botelho, M. F.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-11-06T16:49:11Zoai:estudogeral.uc.pt:10316/5000Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:01:35.429770Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Halogen atom effect on photophysical and photodynamic characteristics of derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin
title Halogen atom effect on photophysical and photodynamic characteristics of derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin
spellingShingle Halogen atom effect on photophysical and photodynamic characteristics of derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin
Serra, A. C.
Halogenated porphyrins
Photodynamic therapy
Heavy atom effect
title_short Halogen atom effect on photophysical and photodynamic characteristics of derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin
title_full Halogen atom effect on photophysical and photodynamic characteristics of derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin
title_fullStr Halogen atom effect on photophysical and photodynamic characteristics of derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin
title_full_unstemmed Halogen atom effect on photophysical and photodynamic characteristics of derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin
title_sort Halogen atom effect on photophysical and photodynamic characteristics of derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin
author Serra, A. C.
author_facet Serra, A. C.
Pineiro, M.
Gonsalves, A. M. d'A. Rocha
Abrantes, M.
Laranjo, M.
Santos, A. C.
Botelho, M. F.
author_role author
author2 Pineiro, M.
Gonsalves, A. M. d'A. Rocha
Abrantes, M.
Laranjo, M.
Santos, A. C.
Botelho, M. F.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Serra, A. C.
Pineiro, M.
Gonsalves, A. M. d'A. Rocha
Abrantes, M.
Laranjo, M.
Santos, A. C.
Botelho, M. F.
dc.subject.por.fl_str_mv Halogenated porphyrins
Photodynamic therapy
Heavy atom effect
topic Halogenated porphyrins
Photodynamic therapy
Heavy atom effect
description Brominated and iodinated derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin were synthesised directly from the corresponding aldehydes. Photophysical and photochemical properties, singlet oxygen formation quantum yields, photobleaching and log P were measured. Cellular uptake measurements and cytotoxicity assays on WiDr and A375 tumour cell lines were performed. 5,10,15,20-Tetrakis(2-bromo-5-hydroxyphenyl)porphyrin showed the best cytotoxicity with values of IC50 of 113 nM over WiDr cells and 52 nM over A375 cells.
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/5000
http://hdl.handle.net/10316/5000
https://doi.org/10.1016/j.jphotobiol.2008.04.006
url http://hdl.handle.net/10316/5000
https://doi.org/10.1016/j.jphotobiol.2008.04.006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Photochemistry and Photobiology B: Biology. 92:1 (2008) 59-65
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eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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