Current insights into the effects of cationic biocides exposure on Enterococcus spp.

Detalhes bibliográficos
Autor(a) principal: Pereira, A.P.
Data de Publicação: 2024
Outros Autores: Antunes, Patrícia, Peixe, L., Freitas, A.R., Novais, Carla
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/159423
Resumo: <jats:p>Cationic biocides (CBs), such as quaternary ammonium compounds and biguanides, are critical for controlling the spread of bacterial pathogens like <jats:italic>Enterococcus</jats:italic> spp., a leading cause of multidrug-resistant healthcare-associated infections. The widespread use of CBs in recent decades has prompted concerns about the potential emergence of <jats:italic>Enterococcus</jats:italic> spp. populations exhibiting resistance to both biocides and antibiotics. Such concerns arise from their frequent exposure to subinhibitory concentrations of CBs in clinical, food chain and diverse environmental settings. This comprehensive narrative review aimed to explore the complexity of the <jats:italic>Enterococcus</jats:italic> response to CBs and of their possible evolution toward resistance. To that end, CBs activity against diverse <jats:italic>Enterococcus</jats:italic> spp. collections, the prevalence and roles of genes associated with decreased susceptibility to CBs, and the potential for co- and cross-resistance between CBs and antibiotics are reviewed. Significant methodological and knowledge gaps are identified, highlighting areas that future studies should address to enhance our comprehension of the impact of exposure to CBs on <jats:italic>Enterococcus</jats:italic> spp. populations epidemiology. This knowledge is essential for developing effective One Health strategies that ensure the continued efficacy of these critical agents in safeguarding Public Health.</jats:p>
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spelling Current insights into the effects of cationic biocides exposure on Enterococcus spp.Ciências da Saúde, Ciências médicas e da saúdeHealth sciences, Medical and Health sciences<jats:p>Cationic biocides (CBs), such as quaternary ammonium compounds and biguanides, are critical for controlling the spread of bacterial pathogens like <jats:italic>Enterococcus</jats:italic> spp., a leading cause of multidrug-resistant healthcare-associated infections. The widespread use of CBs in recent decades has prompted concerns about the potential emergence of <jats:italic>Enterococcus</jats:italic> spp. populations exhibiting resistance to both biocides and antibiotics. Such concerns arise from their frequent exposure to subinhibitory concentrations of CBs in clinical, food chain and diverse environmental settings. This comprehensive narrative review aimed to explore the complexity of the <jats:italic>Enterococcus</jats:italic> response to CBs and of their possible evolution toward resistance. To that end, CBs activity against diverse <jats:italic>Enterococcus</jats:italic> spp. collections, the prevalence and roles of genes associated with decreased susceptibility to CBs, and the potential for co- and cross-resistance between CBs and antibiotics are reviewed. Significant methodological and knowledge gaps are identified, highlighting areas that future studies should address to enhance our comprehension of the impact of exposure to CBs on <jats:italic>Enterococcus</jats:italic> spp. populations epidemiology. This knowledge is essential for developing effective One Health strategies that ensure the continued efficacy of these critical agents in safeguarding Public Health.</jats:p>20242024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/159423eng1664-302X10.3389/fmicb.2024.1392018Pereira, A.P.Antunes, PatríciaPeixe, L.Freitas, A.R.Novais, Carlainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-27T08:47:36Zoai:repositorio-aberto.up.pt:10216/159423Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-27T08:47:36Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Current insights into the effects of cationic biocides exposure on Enterococcus spp.
title Current insights into the effects of cationic biocides exposure on Enterococcus spp.
spellingShingle Current insights into the effects of cationic biocides exposure on Enterococcus spp.
Pereira, A.P.
Ciências da Saúde, Ciências médicas e da saúde
Health sciences, Medical and Health sciences
title_short Current insights into the effects of cationic biocides exposure on Enterococcus spp.
title_full Current insights into the effects of cationic biocides exposure on Enterococcus spp.
title_fullStr Current insights into the effects of cationic biocides exposure on Enterococcus spp.
title_full_unstemmed Current insights into the effects of cationic biocides exposure on Enterococcus spp.
title_sort Current insights into the effects of cationic biocides exposure on Enterococcus spp.
author Pereira, A.P.
author_facet Pereira, A.P.
Antunes, Patrícia
Peixe, L.
Freitas, A.R.
Novais, Carla
author_role author
author2 Antunes, Patrícia
Peixe, L.
Freitas, A.R.
Novais, Carla
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pereira, A.P.
Antunes, Patrícia
Peixe, L.
Freitas, A.R.
Novais, Carla
dc.subject.por.fl_str_mv Ciências da Saúde, Ciências médicas e da saúde
Health sciences, Medical and Health sciences
topic Ciências da Saúde, Ciências médicas e da saúde
Health sciences, Medical and Health sciences
description <jats:p>Cationic biocides (CBs), such as quaternary ammonium compounds and biguanides, are critical for controlling the spread of bacterial pathogens like <jats:italic>Enterococcus</jats:italic> spp., a leading cause of multidrug-resistant healthcare-associated infections. The widespread use of CBs in recent decades has prompted concerns about the potential emergence of <jats:italic>Enterococcus</jats:italic> spp. populations exhibiting resistance to both biocides and antibiotics. Such concerns arise from their frequent exposure to subinhibitory concentrations of CBs in clinical, food chain and diverse environmental settings. This comprehensive narrative review aimed to explore the complexity of the <jats:italic>Enterococcus</jats:italic> response to CBs and of their possible evolution toward resistance. To that end, CBs activity against diverse <jats:italic>Enterococcus</jats:italic> spp. collections, the prevalence and roles of genes associated with decreased susceptibility to CBs, and the potential for co- and cross-resistance between CBs and antibiotics are reviewed. Significant methodological and knowledge gaps are identified, highlighting areas that future studies should address to enhance our comprehension of the impact of exposure to CBs on <jats:italic>Enterococcus</jats:italic> spp. populations epidemiology. This knowledge is essential for developing effective One Health strategies that ensure the continued efficacy of these critical agents in safeguarding Public Health.</jats:p>
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/159423
url https://hdl.handle.net/10216/159423
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1664-302X
10.3389/fmicb.2024.1392018
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dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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