Current insights into the effects of cationic biocides exposure on Enterococcus spp.
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/159423 |
Resumo: | <jats:p>Cationic biocides (CBs), such as quaternary ammonium compounds and biguanides, are critical for controlling the spread of bacterial pathogens like <jats:italic>Enterococcus</jats:italic> spp., a leading cause of multidrug-resistant healthcare-associated infections. The widespread use of CBs in recent decades has prompted concerns about the potential emergence of <jats:italic>Enterococcus</jats:italic> spp. populations exhibiting resistance to both biocides and antibiotics. Such concerns arise from their frequent exposure to subinhibitory concentrations of CBs in clinical, food chain and diverse environmental settings. This comprehensive narrative review aimed to explore the complexity of the <jats:italic>Enterococcus</jats:italic> response to CBs and of their possible evolution toward resistance. To that end, CBs activity against diverse <jats:italic>Enterococcus</jats:italic> spp. collections, the prevalence and roles of genes associated with decreased susceptibility to CBs, and the potential for co- and cross-resistance between CBs and antibiotics are reviewed. Significant methodological and knowledge gaps are identified, highlighting areas that future studies should address to enhance our comprehension of the impact of exposure to CBs on <jats:italic>Enterococcus</jats:italic> spp. populations epidemiology. This knowledge is essential for developing effective One Health strategies that ensure the continued efficacy of these critical agents in safeguarding Public Health.</jats:p> |
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Current insights into the effects of cationic biocides exposure on Enterococcus spp.Ciências da Saúde, Ciências médicas e da saúdeHealth sciences, Medical and Health sciences<jats:p>Cationic biocides (CBs), such as quaternary ammonium compounds and biguanides, are critical for controlling the spread of bacterial pathogens like <jats:italic>Enterococcus</jats:italic> spp., a leading cause of multidrug-resistant healthcare-associated infections. The widespread use of CBs in recent decades has prompted concerns about the potential emergence of <jats:italic>Enterococcus</jats:italic> spp. populations exhibiting resistance to both biocides and antibiotics. Such concerns arise from their frequent exposure to subinhibitory concentrations of CBs in clinical, food chain and diverse environmental settings. This comprehensive narrative review aimed to explore the complexity of the <jats:italic>Enterococcus</jats:italic> response to CBs and of their possible evolution toward resistance. To that end, CBs activity against diverse <jats:italic>Enterococcus</jats:italic> spp. collections, the prevalence and roles of genes associated with decreased susceptibility to CBs, and the potential for co- and cross-resistance between CBs and antibiotics are reviewed. Significant methodological and knowledge gaps are identified, highlighting areas that future studies should address to enhance our comprehension of the impact of exposure to CBs on <jats:italic>Enterococcus</jats:italic> spp. populations epidemiology. This knowledge is essential for developing effective One Health strategies that ensure the continued efficacy of these critical agents in safeguarding Public Health.</jats:p>20242024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/159423eng1664-302X10.3389/fmicb.2024.1392018Pereira, A.P.Antunes, PatríciaPeixe, L.Freitas, A.R.Novais, Carlainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-27T08:47:36Zoai:repositorio-aberto.up.pt:10216/159423Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-27T08:47:36Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Current insights into the effects of cationic biocides exposure on Enterococcus spp. |
title |
Current insights into the effects of cationic biocides exposure on Enterococcus spp. |
spellingShingle |
Current insights into the effects of cationic biocides exposure on Enterococcus spp. Pereira, A.P. Ciências da Saúde, Ciências médicas e da saúde Health sciences, Medical and Health sciences |
title_short |
Current insights into the effects of cationic biocides exposure on Enterococcus spp. |
title_full |
Current insights into the effects of cationic biocides exposure on Enterococcus spp. |
title_fullStr |
Current insights into the effects of cationic biocides exposure on Enterococcus spp. |
title_full_unstemmed |
Current insights into the effects of cationic biocides exposure on Enterococcus spp. |
title_sort |
Current insights into the effects of cationic biocides exposure on Enterococcus spp. |
author |
Pereira, A.P. |
author_facet |
Pereira, A.P. Antunes, Patrícia Peixe, L. Freitas, A.R. Novais, Carla |
author_role |
author |
author2 |
Antunes, Patrícia Peixe, L. Freitas, A.R. Novais, Carla |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Pereira, A.P. Antunes, Patrícia Peixe, L. Freitas, A.R. Novais, Carla |
dc.subject.por.fl_str_mv |
Ciências da Saúde, Ciências médicas e da saúde Health sciences, Medical and Health sciences |
topic |
Ciências da Saúde, Ciências médicas e da saúde Health sciences, Medical and Health sciences |
description |
<jats:p>Cationic biocides (CBs), such as quaternary ammonium compounds and biguanides, are critical for controlling the spread of bacterial pathogens like <jats:italic>Enterococcus</jats:italic> spp., a leading cause of multidrug-resistant healthcare-associated infections. The widespread use of CBs in recent decades has prompted concerns about the potential emergence of <jats:italic>Enterococcus</jats:italic> spp. populations exhibiting resistance to both biocides and antibiotics. Such concerns arise from their frequent exposure to subinhibitory concentrations of CBs in clinical, food chain and diverse environmental settings. This comprehensive narrative review aimed to explore the complexity of the <jats:italic>Enterococcus</jats:italic> response to CBs and of their possible evolution toward resistance. To that end, CBs activity against diverse <jats:italic>Enterococcus</jats:italic> spp. collections, the prevalence and roles of genes associated with decreased susceptibility to CBs, and the potential for co- and cross-resistance between CBs and antibiotics are reviewed. Significant methodological and knowledge gaps are identified, highlighting areas that future studies should address to enhance our comprehension of the impact of exposure to CBs on <jats:italic>Enterococcus</jats:italic> spp. populations epidemiology. This knowledge is essential for developing effective One Health strategies that ensure the continued efficacy of these critical agents in safeguarding Public Health.</jats:p> |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024 2024-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/159423 |
url |
https://hdl.handle.net/10216/159423 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1664-302X 10.3389/fmicb.2024.1392018 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817548031144230912 |