A transcriptomic approach to the metabolism of tetrapyrrolic photosensitizers in a marine annelid

Detalhes bibliográficos
Autor(a) principal: Santos, Maria Leonor
Data de Publicação: 2021
Outros Autores: D’ambrosio, Mariaelena, Rodrigo, Ana P., Parola, A. Jorge, Costa, Pedro M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/136324
Resumo: FA_05_2017_007 UID/Multi/04378/2020 UID/QUI/50006/2020
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spelling A transcriptomic approach to the metabolism of tetrapyrrolic photosensitizers in a marine annelidAnnelidaBile pigmentsBioinformaticsHemePhotodynamicPorphyrin metabolismAnalytical ChemistryChemistry (miscellaneous)Molecular MedicinePharmaceutical ScienceDrug DiscoveryPhysical and Theoretical ChemistryOrganic ChemistrySDG 14 - Life Below WaterFA_05_2017_007 UID/Multi/04378/2020 UID/QUI/50006/2020The past decade has seen growing interest in marine natural pigments for biotechnological applications. One of the most abundant classes of biological pigments is the tetrapyrroles, which are prized targets due their photodynamic properties; porphyrins are the best known examples of this group. Many animal porphyrinoids and other tetrapyrroles are produced through heme metabolic pathways, the best known of which are the bile pigments biliverdin and bilirubin. Eulalia is a marine Polychaeta characterized by its bright green coloration resulting from a remarkably wide range of greenish and yellowish tetrapyrroles, some of which have promising photodynamic properties. The present study combined metabolomics based on HPLC-DAD with RNA-seq transcriptomics to investigate the molecular pathways of porphyrinoid metabolism by comparing the worm’s proboscis and epidermis, which display distinct pigmentation patterns. The results showed that pigments are endogenous and seemingly heme-derived. The worm possesses homologs in both organs for genes encoding enzymes involved in heme metabolism such as ALAD, FECH, UROS, and PPOX. However, the findings also indicate that variants of the canonical enzymes of the heme biosynthesis pathway can be species-and organ-specific. These differences between molecular networks contribute to explain not only the differential pigmentation patterns between organs, but also the worm’s variety of novel endogenous tetrapyrrolic compounds.DCV - Departamento de Ciências da VidaUCIBIO - Applied Molecular Biosciences UnitLAQV@REQUIMTEDQ - Departamento de QuímicaRUNSantos, Maria LeonorD’ambrosio, MariaelenaRodrigo, Ana P.Parola, A. JorgeCosta, Pedro M.2022-04-12T22:47:48Z2021-06-272021-06-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/136324eng1420-3049PURE: 42843059https://doi.org/10.3390/molecules26133924info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:14:28Zoai:run.unl.pt:10362/136324Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:41.081414Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A transcriptomic approach to the metabolism of tetrapyrrolic photosensitizers in a marine annelid
title A transcriptomic approach to the metabolism of tetrapyrrolic photosensitizers in a marine annelid
spellingShingle A transcriptomic approach to the metabolism of tetrapyrrolic photosensitizers in a marine annelid
Santos, Maria Leonor
Annelida
Bile pigments
Bioinformatics
Heme
Photodynamic
Porphyrin metabolism
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
SDG 14 - Life Below Water
title_short A transcriptomic approach to the metabolism of tetrapyrrolic photosensitizers in a marine annelid
title_full A transcriptomic approach to the metabolism of tetrapyrrolic photosensitizers in a marine annelid
title_fullStr A transcriptomic approach to the metabolism of tetrapyrrolic photosensitizers in a marine annelid
title_full_unstemmed A transcriptomic approach to the metabolism of tetrapyrrolic photosensitizers in a marine annelid
title_sort A transcriptomic approach to the metabolism of tetrapyrrolic photosensitizers in a marine annelid
author Santos, Maria Leonor
author_facet Santos, Maria Leonor
D’ambrosio, Mariaelena
Rodrigo, Ana P.
Parola, A. Jorge
Costa, Pedro M.
author_role author
author2 D’ambrosio, Mariaelena
Rodrigo, Ana P.
Parola, A. Jorge
Costa, Pedro M.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv DCV - Departamento de Ciências da Vida
UCIBIO - Applied Molecular Biosciences Unit
LAQV@REQUIMTE
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Santos, Maria Leonor
D’ambrosio, Mariaelena
Rodrigo, Ana P.
Parola, A. Jorge
Costa, Pedro M.
dc.subject.por.fl_str_mv Annelida
Bile pigments
Bioinformatics
Heme
Photodynamic
Porphyrin metabolism
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
SDG 14 - Life Below Water
topic Annelida
Bile pigments
Bioinformatics
Heme
Photodynamic
Porphyrin metabolism
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
SDG 14 - Life Below Water
description FA_05_2017_007 UID/Multi/04378/2020 UID/QUI/50006/2020
publishDate 2021
dc.date.none.fl_str_mv 2021-06-27
2021-06-27T00:00:00Z
2022-04-12T22:47:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/136324
url http://hdl.handle.net/10362/136324
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1420-3049
PURE: 42843059
https://doi.org/10.3390/molecules26133924
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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