Toxoplasma gondii seroprevalence in the Portuguese population: comparison of three cross-sectional studies spanning three decades
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/4190 |
Resumo: | Background: Toxoplasma gondii is an obligate intracellular protozoan infecting up to one-third of the world's population, constituting a life threat if transmitted from mother to child during pregnancy. In Portugal, there is a lack of knowledge of the current epidemiological situation, as the unique toxoplasmosis National Serological Survey was performed in 1979/1980. Methods: We studied the seroprevalence trends in the Portuguese general population over the past 3 decades, by assessing chronological spread cross-sectional studies, with special focus on women of childbearing age, by age group, region and gender. Results: The T. gondii overall seroprevalence decreased from 47% in 1979/1980 to 22% (95% CI 20% to 24%) in 2013. Generally, we observed that the prevalence of T. gondii IgG increased significantly with age and it decreased over time, both in the general population and in the childbearing women (18% prevalence in 2013). Conclusions: The scenario observed for the latter indicates that more than 80% of childbearing women are susceptible to primary infection yielding a risk of congenital toxoplasmosis and respective sequelae. Since there is no vaccine to prevent human toxoplasmosis, the improvement of primary prevention constitutes a major tool to avoid infection in such susceptible groups. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Toxoplasma gondii seroprevalence in the Portuguese population: comparison of three cross-sectional studies spanning three decadesToxoplasma gondiiSeroprevalencePortugalEpidemiologyParasitologyInfectious DiseasesInfecções Sistémicas e ZoonosesBackground: Toxoplasma gondii is an obligate intracellular protozoan infecting up to one-third of the world's population, constituting a life threat if transmitted from mother to child during pregnancy. In Portugal, there is a lack of knowledge of the current epidemiological situation, as the unique toxoplasmosis National Serological Survey was performed in 1979/1980. Methods: We studied the seroprevalence trends in the Portuguese general population over the past 3 decades, by assessing chronological spread cross-sectional studies, with special focus on women of childbearing age, by age group, region and gender. Results: The T. gondii overall seroprevalence decreased from 47% in 1979/1980 to 22% (95% CI 20% to 24%) in 2013. Generally, we observed that the prevalence of T. gondii IgG increased significantly with age and it decreased over time, both in the general population and in the childbearing women (18% prevalence in 2013). Conclusions: The scenario observed for the latter indicates that more than 80% of childbearing women are susceptible to primary infection yielding a risk of congenital toxoplasmosis and respective sequelae. Since there is no vaccine to prevent human toxoplasmosis, the improvement of primary prevention constitutes a major tool to avoid infection in such susceptible groups.The Portuguese National Institute of Health funded this study.BMJ Publishing GroupRepositório Científico do Instituto Nacional de SaúdeGargaté, Maria JoãoFerreira, IdalinaVilares, AnabelaMartins, SusanaCardoso, CarlosSilva, SusanaNunes, BaltazarGomes, João Paulo2017-02-15T18:08:28Z2016-10-052016-10-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4190engBMJ Open. 2016 Oct 5;6(10):e011648. doi: 10.1136/bmjopen-2016-011648.2044-605510.1136/bmjopen-2016-011648info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:20Zoai:repositorio.insa.pt:10400.18/4190Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:13.361170Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Toxoplasma gondii seroprevalence in the Portuguese population: comparison of three cross-sectional studies spanning three decades |
title |
Toxoplasma gondii seroprevalence in the Portuguese population: comparison of three cross-sectional studies spanning three decades |
spellingShingle |
Toxoplasma gondii seroprevalence in the Portuguese population: comparison of three cross-sectional studies spanning three decades Gargaté, Maria João Toxoplasma gondii Seroprevalence Portugal Epidemiology Parasitology Infectious Diseases Infecções Sistémicas e Zoonoses |
title_short |
Toxoplasma gondii seroprevalence in the Portuguese population: comparison of three cross-sectional studies spanning three decades |
title_full |
Toxoplasma gondii seroprevalence in the Portuguese population: comparison of three cross-sectional studies spanning three decades |
title_fullStr |
Toxoplasma gondii seroprevalence in the Portuguese population: comparison of three cross-sectional studies spanning three decades |
title_full_unstemmed |
Toxoplasma gondii seroprevalence in the Portuguese population: comparison of three cross-sectional studies spanning three decades |
title_sort |
Toxoplasma gondii seroprevalence in the Portuguese population: comparison of three cross-sectional studies spanning three decades |
author |
Gargaté, Maria João |
author_facet |
Gargaté, Maria João Ferreira, Idalina Vilares, Anabela Martins, Susana Cardoso, Carlos Silva, Susana Nunes, Baltazar Gomes, João Paulo |
author_role |
author |
author2 |
Ferreira, Idalina Vilares, Anabela Martins, Susana Cardoso, Carlos Silva, Susana Nunes, Baltazar Gomes, João Paulo |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Gargaté, Maria João Ferreira, Idalina Vilares, Anabela Martins, Susana Cardoso, Carlos Silva, Susana Nunes, Baltazar Gomes, João Paulo |
dc.subject.por.fl_str_mv |
Toxoplasma gondii Seroprevalence Portugal Epidemiology Parasitology Infectious Diseases Infecções Sistémicas e Zoonoses |
topic |
Toxoplasma gondii Seroprevalence Portugal Epidemiology Parasitology Infectious Diseases Infecções Sistémicas e Zoonoses |
description |
Background: Toxoplasma gondii is an obligate intracellular protozoan infecting up to one-third of the world's population, constituting a life threat if transmitted from mother to child during pregnancy. In Portugal, there is a lack of knowledge of the current epidemiological situation, as the unique toxoplasmosis National Serological Survey was performed in 1979/1980. Methods: We studied the seroprevalence trends in the Portuguese general population over the past 3 decades, by assessing chronological spread cross-sectional studies, with special focus on women of childbearing age, by age group, region and gender. Results: The T. gondii overall seroprevalence decreased from 47% in 1979/1980 to 22% (95% CI 20% to 24%) in 2013. Generally, we observed that the prevalence of T. gondii IgG increased significantly with age and it decreased over time, both in the general population and in the childbearing women (18% prevalence in 2013). Conclusions: The scenario observed for the latter indicates that more than 80% of childbearing women are susceptible to primary infection yielding a risk of congenital toxoplasmosis and respective sequelae. Since there is no vaccine to prevent human toxoplasmosis, the improvement of primary prevention constitutes a major tool to avoid infection in such susceptible groups. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-10-05 2016-10-05T00:00:00Z 2017-02-15T18:08:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/4190 |
url |
http://hdl.handle.net/10400.18/4190 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BMJ Open. 2016 Oct 5;6(10):e011648. doi: 10.1136/bmjopen-2016-011648. 2044-6055 10.1136/bmjopen-2016-011648 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
BMJ Publishing Group |
publisher.none.fl_str_mv |
BMJ Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132130840674304 |