Immune response: the Achilles’ heel of the stem cell-based regenerative therapies

Detalhes bibliográficos
Autor(a) principal: Oliveira, Cláudia S.
Data de Publicação: 2023
Outros Autores: Tavaria, Freni K.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.14/41799
Resumo: Besides trauma, several pathological conditions which directly affect the normal functioning of organs, require new therapeutic strategies to repair damaged or diseased tissues. Tissue regeneration is a complex and spatiotemporal process involving a plethora of cell types, including various immune cells and stem cells in a synchronized relationship. However, individual parameters, namely ageing, obesity, diabetes, and chronic conditions, have been intrinsically correlated with poor regenerative properties of adult tissues. While vast progress has been made regarding stem cell-based therapy to direct self-healing, the immune response is still the Achilles’ heel of such strategies. Whereas the role of effector immune cells has been well defined along the regenerative process, an understanding of the behavior of the main adult stem cells, namely mesenchymal stem cells (MSCs) and hematopoietic stem and progenitor cells (HSPCs), along the different phases of the regenerative process could clarify how these stem cells can be used to positively influence the immune response. In this scope, this review highlights the main interactions between these stem cells and immune cells during tissue repair, exploring the most important regenerative properties of stem cells and correlating them with the modulation of the immune response during tissue regeneration. Furthermore, the utmost strategies used to explore how the behavior and stem cell fate are affected by specific microenvironments and/or stimuli usually found during a regenerative process, are emphasized. This clarification may provide critical insight into the molecular mechanisms by which stem cells modulate the immune response in a positive feedback loop toward tissue repair.
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spelling Immune response: the Achilles’ heel of the stem cell-based regenerative therapiesMesenchymal stem cellsHematopoietic stem cellsTissue regenerationImmune responseImmunomodulationStem cell-based therapiesRegenerative propertiesBesides trauma, several pathological conditions which directly affect the normal functioning of organs, require new therapeutic strategies to repair damaged or diseased tissues. Tissue regeneration is a complex and spatiotemporal process involving a plethora of cell types, including various immune cells and stem cells in a synchronized relationship. However, individual parameters, namely ageing, obesity, diabetes, and chronic conditions, have been intrinsically correlated with poor regenerative properties of adult tissues. While vast progress has been made regarding stem cell-based therapy to direct self-healing, the immune response is still the Achilles’ heel of such strategies. Whereas the role of effector immune cells has been well defined along the regenerative process, an understanding of the behavior of the main adult stem cells, namely mesenchymal stem cells (MSCs) and hematopoietic stem and progenitor cells (HSPCs), along the different phases of the regenerative process could clarify how these stem cells can be used to positively influence the immune response. In this scope, this review highlights the main interactions between these stem cells and immune cells during tissue repair, exploring the most important regenerative properties of stem cells and correlating them with the modulation of the immune response during tissue regeneration. Furthermore, the utmost strategies used to explore how the behavior and stem cell fate are affected by specific microenvironments and/or stimuli usually found during a regenerative process, are emphasized. This clarification may provide critical insight into the molecular mechanisms by which stem cells modulate the immune response in a positive feedback loop toward tissue repair.Veritati - Repositório Institucional da Universidade Católica PortuguesaOliveira, Cláudia S.Tavaria, Freni K.2023-07-19T15:57:37Z2023-06-302023-06-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/41799eng2768-665510.37349/ei.2023.0010085170046064info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-19T01:41:51Zoai:repositorio.ucp.pt:10400.14/41799Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:09:27.183617Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Immune response: the Achilles’ heel of the stem cell-based regenerative therapies
title Immune response: the Achilles’ heel of the stem cell-based regenerative therapies
spellingShingle Immune response: the Achilles’ heel of the stem cell-based regenerative therapies
Oliveira, Cláudia S.
Mesenchymal stem cells
Hematopoietic stem cells
Tissue regeneration
Immune response
Immunomodulation
Stem cell-based therapies
Regenerative properties
title_short Immune response: the Achilles’ heel of the stem cell-based regenerative therapies
title_full Immune response: the Achilles’ heel of the stem cell-based regenerative therapies
title_fullStr Immune response: the Achilles’ heel of the stem cell-based regenerative therapies
title_full_unstemmed Immune response: the Achilles’ heel of the stem cell-based regenerative therapies
title_sort Immune response: the Achilles’ heel of the stem cell-based regenerative therapies
author Oliveira, Cláudia S.
author_facet Oliveira, Cláudia S.
Tavaria, Freni K.
author_role author
author2 Tavaria, Freni K.
author2_role author
dc.contributor.none.fl_str_mv Veritati - Repositório Institucional da Universidade Católica Portuguesa
dc.contributor.author.fl_str_mv Oliveira, Cláudia S.
Tavaria, Freni K.
dc.subject.por.fl_str_mv Mesenchymal stem cells
Hematopoietic stem cells
Tissue regeneration
Immune response
Immunomodulation
Stem cell-based therapies
Regenerative properties
topic Mesenchymal stem cells
Hematopoietic stem cells
Tissue regeneration
Immune response
Immunomodulation
Stem cell-based therapies
Regenerative properties
description Besides trauma, several pathological conditions which directly affect the normal functioning of organs, require new therapeutic strategies to repair damaged or diseased tissues. Tissue regeneration is a complex and spatiotemporal process involving a plethora of cell types, including various immune cells and stem cells in a synchronized relationship. However, individual parameters, namely ageing, obesity, diabetes, and chronic conditions, have been intrinsically correlated with poor regenerative properties of adult tissues. While vast progress has been made regarding stem cell-based therapy to direct self-healing, the immune response is still the Achilles’ heel of such strategies. Whereas the role of effector immune cells has been well defined along the regenerative process, an understanding of the behavior of the main adult stem cells, namely mesenchymal stem cells (MSCs) and hematopoietic stem and progenitor cells (HSPCs), along the different phases of the regenerative process could clarify how these stem cells can be used to positively influence the immune response. In this scope, this review highlights the main interactions between these stem cells and immune cells during tissue repair, exploring the most important regenerative properties of stem cells and correlating them with the modulation of the immune response during tissue regeneration. Furthermore, the utmost strategies used to explore how the behavior and stem cell fate are affected by specific microenvironments and/or stimuli usually found during a regenerative process, are emphasized. This clarification may provide critical insight into the molecular mechanisms by which stem cells modulate the immune response in a positive feedback loop toward tissue repair.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-19T15:57:37Z
2023-06-30
2023-06-30T00:00:00Z
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dc.language.iso.fl_str_mv eng
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10.37349/ei.2023.00100
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