Gliomas and the vascular fragility of the blood brain barrier

Detalhes bibliográficos
Autor(a) principal: Dubois, Luiz Gustavo
Data de Publicação: 2014
Outros Autores: Campanati, Loraine, Righy, Cassia, D'Andrea-Meira, Isabella, Spohr, Tania Cristina Leite de Sampaio E, Porto-Carreiro, Isabel, Pereira, Claudia Maria, Balça-Silva, Joana, Kahn, Suzana Assad, DosSantos, Marcos F., Oliveira, Marcela de Almeida Rabello, Ximenes-da-Silva, Adriana, Lopes, Maria Celeste, Faveret, Eduardo, Gasparetto, Emerson Leandro, Moura-Neto, Vivaldo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/109424
https://doi.org/10.3389/fncel.2014.00418
Resumo: Astrocytes, members of the glial family, interact through the exchange of soluble factors or by directly contacting neurons and other brain cells, such as microglia and endothelial cells. Astrocytic projections interact with vessels and act as additional elements of the Blood Brain Barrier (BBB). By mechanisms not fully understood, astrocytes can undergo oncogenic transformation and give rise to gliomas. The tumors take advantage of the BBB to ensure survival and continuous growth. A glioma can develop into a very aggressive tumor, the glioblastoma (GBM), characterized by a highly heterogeneous cell population (including tumor stem cells), extensive proliferation and migration. Nevertheless, gliomas can also give rise to slow growing tumors and in both cases, the afflux of blood, via BBB is crucial. Glioma cells migrate to different regions of the brain guided by the extension of blood vessels, colonizing the healthy adjacent tissue. In the clinical context, GBM can lead to tumor-derived seizures, which represent a challenge to patients and clinicians, since drugs used for its treatment must be able to cross the BBB. Uncontrolled and fast growth also leads to the disruption of the chimeric and fragile vessels in the tumor mass resulting in peritumoral edema. Although hormonal therapy is currently used to control the edema, it is not always efficient. In this review we comment the points cited above, considering the importance of the BBB and the concerns that arise when this barrier is affected.
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spelling Gliomas and the vascular fragility of the blood brain barrierglioblastomablood-brain barriermiRNAexosomesneural stem cellstumor-related epileptic seizuresbrain tumor related edemaAstrocytes, members of the glial family, interact through the exchange of soluble factors or by directly contacting neurons and other brain cells, such as microglia and endothelial cells. Astrocytic projections interact with vessels and act as additional elements of the Blood Brain Barrier (BBB). By mechanisms not fully understood, astrocytes can undergo oncogenic transformation and give rise to gliomas. The tumors take advantage of the BBB to ensure survival and continuous growth. A glioma can develop into a very aggressive tumor, the glioblastoma (GBM), characterized by a highly heterogeneous cell population (including tumor stem cells), extensive proliferation and migration. Nevertheless, gliomas can also give rise to slow growing tumors and in both cases, the afflux of blood, via BBB is crucial. Glioma cells migrate to different regions of the brain guided by the extension of blood vessels, colonizing the healthy adjacent tissue. In the clinical context, GBM can lead to tumor-derived seizures, which represent a challenge to patients and clinicians, since drugs used for its treatment must be able to cross the BBB. Uncontrolled and fast growth also leads to the disruption of the chimeric and fragile vessels in the tumor mass resulting in peritumoral edema. Although hormonal therapy is currently used to control the edema, it is not always efficient. In this review we comment the points cited above, considering the importance of the BBB and the concerns that arise when this barrier is affected.Frontiers Media S.A.2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109424http://hdl.handle.net/10316/109424https://doi.org/10.3389/fncel.2014.00418eng1662-5102Dubois, Luiz GustavoCampanati, LoraineRighy, CassiaD'Andrea-Meira, IsabellaSpohr, Tania Cristina Leite de Sampaio EPorto-Carreiro, IsabelPereira, Claudia MariaBalça-Silva, JoanaKahn, Suzana AssadDosSantos, Marcos F.Oliveira, Marcela de Almeida RabelloXimenes-da-Silva, AdrianaLopes, Maria CelesteFaveret, EduardoGasparetto, Emerson LeandroMoura-Neto, Vivaldoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-13T10:40:56Zoai:estudogeral.uc.pt:10316/109424Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:37.370550Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Gliomas and the vascular fragility of the blood brain barrier
title Gliomas and the vascular fragility of the blood brain barrier
spellingShingle Gliomas and the vascular fragility of the blood brain barrier
Dubois, Luiz Gustavo
glioblastoma
blood-brain barrier
miRNA
exosomes
neural stem cells
tumor-related epileptic seizures
brain tumor related edema
title_short Gliomas and the vascular fragility of the blood brain barrier
title_full Gliomas and the vascular fragility of the blood brain barrier
title_fullStr Gliomas and the vascular fragility of the blood brain barrier
title_full_unstemmed Gliomas and the vascular fragility of the blood brain barrier
title_sort Gliomas and the vascular fragility of the blood brain barrier
author Dubois, Luiz Gustavo
author_facet Dubois, Luiz Gustavo
Campanati, Loraine
Righy, Cassia
D'Andrea-Meira, Isabella
Spohr, Tania Cristina Leite de Sampaio E
Porto-Carreiro, Isabel
Pereira, Claudia Maria
Balça-Silva, Joana
Kahn, Suzana Assad
DosSantos, Marcos F.
Oliveira, Marcela de Almeida Rabello
Ximenes-da-Silva, Adriana
Lopes, Maria Celeste
Faveret, Eduardo
Gasparetto, Emerson Leandro
Moura-Neto, Vivaldo
author_role author
author2 Campanati, Loraine
Righy, Cassia
D'Andrea-Meira, Isabella
Spohr, Tania Cristina Leite de Sampaio E
Porto-Carreiro, Isabel
Pereira, Claudia Maria
Balça-Silva, Joana
Kahn, Suzana Assad
DosSantos, Marcos F.
Oliveira, Marcela de Almeida Rabello
Ximenes-da-Silva, Adriana
Lopes, Maria Celeste
Faveret, Eduardo
Gasparetto, Emerson Leandro
Moura-Neto, Vivaldo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dubois, Luiz Gustavo
Campanati, Loraine
Righy, Cassia
D'Andrea-Meira, Isabella
Spohr, Tania Cristina Leite de Sampaio E
Porto-Carreiro, Isabel
Pereira, Claudia Maria
Balça-Silva, Joana
Kahn, Suzana Assad
DosSantos, Marcos F.
Oliveira, Marcela de Almeida Rabello
Ximenes-da-Silva, Adriana
Lopes, Maria Celeste
Faveret, Eduardo
Gasparetto, Emerson Leandro
Moura-Neto, Vivaldo
dc.subject.por.fl_str_mv glioblastoma
blood-brain barrier
miRNA
exosomes
neural stem cells
tumor-related epileptic seizures
brain tumor related edema
topic glioblastoma
blood-brain barrier
miRNA
exosomes
neural stem cells
tumor-related epileptic seizures
brain tumor related edema
description Astrocytes, members of the glial family, interact through the exchange of soluble factors or by directly contacting neurons and other brain cells, such as microglia and endothelial cells. Astrocytic projections interact with vessels and act as additional elements of the Blood Brain Barrier (BBB). By mechanisms not fully understood, astrocytes can undergo oncogenic transformation and give rise to gliomas. The tumors take advantage of the BBB to ensure survival and continuous growth. A glioma can develop into a very aggressive tumor, the glioblastoma (GBM), characterized by a highly heterogeneous cell population (including tumor stem cells), extensive proliferation and migration. Nevertheless, gliomas can also give rise to slow growing tumors and in both cases, the afflux of blood, via BBB is crucial. Glioma cells migrate to different regions of the brain guided by the extension of blood vessels, colonizing the healthy adjacent tissue. In the clinical context, GBM can lead to tumor-derived seizures, which represent a challenge to patients and clinicians, since drugs used for its treatment must be able to cross the BBB. Uncontrolled and fast growth also leads to the disruption of the chimeric and fragile vessels in the tumor mass resulting in peritumoral edema. Although hormonal therapy is currently used to control the edema, it is not always efficient. In this review we comment the points cited above, considering the importance of the BBB and the concerns that arise when this barrier is affected.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/109424
http://hdl.handle.net/10316/109424
https://doi.org/10.3389/fncel.2014.00418
url http://hdl.handle.net/10316/109424
https://doi.org/10.3389/fncel.2014.00418
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1662-5102
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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