Gliomas and the vascular fragility of the blood brain barrier
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/109424 https://doi.org/10.3389/fncel.2014.00418 |
Resumo: | Astrocytes, members of the glial family, interact through the exchange of soluble factors or by directly contacting neurons and other brain cells, such as microglia and endothelial cells. Astrocytic projections interact with vessels and act as additional elements of the Blood Brain Barrier (BBB). By mechanisms not fully understood, astrocytes can undergo oncogenic transformation and give rise to gliomas. The tumors take advantage of the BBB to ensure survival and continuous growth. A glioma can develop into a very aggressive tumor, the glioblastoma (GBM), characterized by a highly heterogeneous cell population (including tumor stem cells), extensive proliferation and migration. Nevertheless, gliomas can also give rise to slow growing tumors and in both cases, the afflux of blood, via BBB is crucial. Glioma cells migrate to different regions of the brain guided by the extension of blood vessels, colonizing the healthy adjacent tissue. In the clinical context, GBM can lead to tumor-derived seizures, which represent a challenge to patients and clinicians, since drugs used for its treatment must be able to cross the BBB. Uncontrolled and fast growth also leads to the disruption of the chimeric and fragile vessels in the tumor mass resulting in peritumoral edema. Although hormonal therapy is currently used to control the edema, it is not always efficient. In this review we comment the points cited above, considering the importance of the BBB and the concerns that arise when this barrier is affected. |
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Gliomas and the vascular fragility of the blood brain barrierglioblastomablood-brain barriermiRNAexosomesneural stem cellstumor-related epileptic seizuresbrain tumor related edemaAstrocytes, members of the glial family, interact through the exchange of soluble factors or by directly contacting neurons and other brain cells, such as microglia and endothelial cells. Astrocytic projections interact with vessels and act as additional elements of the Blood Brain Barrier (BBB). By mechanisms not fully understood, astrocytes can undergo oncogenic transformation and give rise to gliomas. The tumors take advantage of the BBB to ensure survival and continuous growth. A glioma can develop into a very aggressive tumor, the glioblastoma (GBM), characterized by a highly heterogeneous cell population (including tumor stem cells), extensive proliferation and migration. Nevertheless, gliomas can also give rise to slow growing tumors and in both cases, the afflux of blood, via BBB is crucial. Glioma cells migrate to different regions of the brain guided by the extension of blood vessels, colonizing the healthy adjacent tissue. In the clinical context, GBM can lead to tumor-derived seizures, which represent a challenge to patients and clinicians, since drugs used for its treatment must be able to cross the BBB. Uncontrolled and fast growth also leads to the disruption of the chimeric and fragile vessels in the tumor mass resulting in peritumoral edema. Although hormonal therapy is currently used to control the edema, it is not always efficient. In this review we comment the points cited above, considering the importance of the BBB and the concerns that arise when this barrier is affected.Frontiers Media S.A.2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109424http://hdl.handle.net/10316/109424https://doi.org/10.3389/fncel.2014.00418eng1662-5102Dubois, Luiz GustavoCampanati, LoraineRighy, CassiaD'Andrea-Meira, IsabellaSpohr, Tania Cristina Leite de Sampaio EPorto-Carreiro, IsabelPereira, Claudia MariaBalça-Silva, JoanaKahn, Suzana AssadDosSantos, Marcos F.Oliveira, Marcela de Almeida RabelloXimenes-da-Silva, AdrianaLopes, Maria CelesteFaveret, EduardoGasparetto, Emerson LeandroMoura-Neto, Vivaldoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-13T10:40:56Zoai:estudogeral.uc.pt:10316/109424Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:37.370550Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Gliomas and the vascular fragility of the blood brain barrier |
title |
Gliomas and the vascular fragility of the blood brain barrier |
spellingShingle |
Gliomas and the vascular fragility of the blood brain barrier Dubois, Luiz Gustavo glioblastoma blood-brain barrier miRNA exosomes neural stem cells tumor-related epileptic seizures brain tumor related edema |
title_short |
Gliomas and the vascular fragility of the blood brain barrier |
title_full |
Gliomas and the vascular fragility of the blood brain barrier |
title_fullStr |
Gliomas and the vascular fragility of the blood brain barrier |
title_full_unstemmed |
Gliomas and the vascular fragility of the blood brain barrier |
title_sort |
Gliomas and the vascular fragility of the blood brain barrier |
author |
Dubois, Luiz Gustavo |
author_facet |
Dubois, Luiz Gustavo Campanati, Loraine Righy, Cassia D'Andrea-Meira, Isabella Spohr, Tania Cristina Leite de Sampaio E Porto-Carreiro, Isabel Pereira, Claudia Maria Balça-Silva, Joana Kahn, Suzana Assad DosSantos, Marcos F. Oliveira, Marcela de Almeida Rabello Ximenes-da-Silva, Adriana Lopes, Maria Celeste Faveret, Eduardo Gasparetto, Emerson Leandro Moura-Neto, Vivaldo |
author_role |
author |
author2 |
Campanati, Loraine Righy, Cassia D'Andrea-Meira, Isabella Spohr, Tania Cristina Leite de Sampaio E Porto-Carreiro, Isabel Pereira, Claudia Maria Balça-Silva, Joana Kahn, Suzana Assad DosSantos, Marcos F. Oliveira, Marcela de Almeida Rabello Ximenes-da-Silva, Adriana Lopes, Maria Celeste Faveret, Eduardo Gasparetto, Emerson Leandro Moura-Neto, Vivaldo |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Dubois, Luiz Gustavo Campanati, Loraine Righy, Cassia D'Andrea-Meira, Isabella Spohr, Tania Cristina Leite de Sampaio E Porto-Carreiro, Isabel Pereira, Claudia Maria Balça-Silva, Joana Kahn, Suzana Assad DosSantos, Marcos F. Oliveira, Marcela de Almeida Rabello Ximenes-da-Silva, Adriana Lopes, Maria Celeste Faveret, Eduardo Gasparetto, Emerson Leandro Moura-Neto, Vivaldo |
dc.subject.por.fl_str_mv |
glioblastoma blood-brain barrier miRNA exosomes neural stem cells tumor-related epileptic seizures brain tumor related edema |
topic |
glioblastoma blood-brain barrier miRNA exosomes neural stem cells tumor-related epileptic seizures brain tumor related edema |
description |
Astrocytes, members of the glial family, interact through the exchange of soluble factors or by directly contacting neurons and other brain cells, such as microglia and endothelial cells. Astrocytic projections interact with vessels and act as additional elements of the Blood Brain Barrier (BBB). By mechanisms not fully understood, astrocytes can undergo oncogenic transformation and give rise to gliomas. The tumors take advantage of the BBB to ensure survival and continuous growth. A glioma can develop into a very aggressive tumor, the glioblastoma (GBM), characterized by a highly heterogeneous cell population (including tumor stem cells), extensive proliferation and migration. Nevertheless, gliomas can also give rise to slow growing tumors and in both cases, the afflux of blood, via BBB is crucial. Glioma cells migrate to different regions of the brain guided by the extension of blood vessels, colonizing the healthy adjacent tissue. In the clinical context, GBM can lead to tumor-derived seizures, which represent a challenge to patients and clinicians, since drugs used for its treatment must be able to cross the BBB. Uncontrolled and fast growth also leads to the disruption of the chimeric and fragile vessels in the tumor mass resulting in peritumoral edema. Although hormonal therapy is currently used to control the edema, it is not always efficient. In this review we comment the points cited above, considering the importance of the BBB and the concerns that arise when this barrier is affected. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/109424 http://hdl.handle.net/10316/109424 https://doi.org/10.3389/fncel.2014.00418 |
url |
http://hdl.handle.net/10316/109424 https://doi.org/10.3389/fncel.2014.00418 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1662-5102 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Frontiers Media S.A. |
publisher.none.fl_str_mv |
Frontiers Media S.A. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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