Lipocalin-2 is involved in emotional behaviors and cognitive function

Detalhes bibliográficos
Autor(a) principal: Ferreira, Ana Catarina
Data de Publicação: 2013
Outros Autores: Pinto, Vítor, Mesquita, Sandro, Novais, Ashley Cruz, Sousa, João Carlos, Neves, Margarida Correia, Sousa, Nuno, Palha, Joana Almeida, Marques, Fernanda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/27954
Resumo: Lipocalin-2 is involved in emotional behaviors and cognitive function
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spelling Lipocalin-2 is involved in emotional behaviors and cognitive functionLipocalin-2BehaviorAnxietyDepressionHippocampusScience & TechnologyLipocalin-2 is involved in emotional behaviors and cognitive functionLipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard housing conditions, LCN2-null mice display anxious and depressive-like behaviors, as well as cognitive impairment in spatial learning tasks. These behavioral alterations were associated with a hyperactivation of the hypothalamic-pituitary-adrenal axis and with an altered brain cytoarchitecture in the hippocampus. More specifically, we found that the granular and pyramidal neurons of the ventral hippocampus, a region described to be associated with emotion, were hypertrophic, while neurons from the dorsal hippocampus, a region implicated in memory and cognition, were atrophic. In addition, LCN2-null mice presented synaptic impairment in hippocampal long-term potentiation. Whether the LCN2 effects are mediated through modulation of the level of corticosteroids or through a novel mechanism, the present observations bring further into light this immune-related protein as a player in the fine-tuning of behavior and of synaptic activity.We are grateful to Professor Shizuo Akira and Professor Cevayir Coban for the LCN2-null mice in the BALB/c background and to Professor Trude Flo for the LCN2-null mice in C57BL/6J background. Ana C. Ferreira, Sandro D. Mesquita, and Ashley Novais are recipients of Ph.D. and Fernanda Marques and Vitor Pinto are recipients of postdoctoral fellowships from Fundacao para a Ciencia e Tecnologia (Portugal).Frontiers MediaUniversidade do MinhoFerreira, Ana CatarinaPinto, VítorMesquita, SandroNovais, Ashley CruzSousa, João CarlosNeves, Margarida CorreiaSousa, NunoPalha, Joana AlmeidaMarques, Fernanda20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/27954eng1662-510210.3389/fncel.2013.00122http://www.frontiersin.org/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:21:20Zoai:repositorium.sdum.uminho.pt:1822/27954Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:14:36.746338Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Lipocalin-2 is involved in emotional behaviors and cognitive function
title Lipocalin-2 is involved in emotional behaviors and cognitive function
spellingShingle Lipocalin-2 is involved in emotional behaviors and cognitive function
Ferreira, Ana Catarina
Lipocalin-2
Behavior
Anxiety
Depression
Hippocampus
Science & Technology
title_short Lipocalin-2 is involved in emotional behaviors and cognitive function
title_full Lipocalin-2 is involved in emotional behaviors and cognitive function
title_fullStr Lipocalin-2 is involved in emotional behaviors and cognitive function
title_full_unstemmed Lipocalin-2 is involved in emotional behaviors and cognitive function
title_sort Lipocalin-2 is involved in emotional behaviors and cognitive function
author Ferreira, Ana Catarina
author_facet Ferreira, Ana Catarina
Pinto, Vítor
Mesquita, Sandro
Novais, Ashley Cruz
Sousa, João Carlos
Neves, Margarida Correia
Sousa, Nuno
Palha, Joana Almeida
Marques, Fernanda
author_role author
author2 Pinto, Vítor
Mesquita, Sandro
Novais, Ashley Cruz
Sousa, João Carlos
Neves, Margarida Correia
Sousa, Nuno
Palha, Joana Almeida
Marques, Fernanda
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Ferreira, Ana Catarina
Pinto, Vítor
Mesquita, Sandro
Novais, Ashley Cruz
Sousa, João Carlos
Neves, Margarida Correia
Sousa, Nuno
Palha, Joana Almeida
Marques, Fernanda
dc.subject.por.fl_str_mv Lipocalin-2
Behavior
Anxiety
Depression
Hippocampus
Science & Technology
topic Lipocalin-2
Behavior
Anxiety
Depression
Hippocampus
Science & Technology
description Lipocalin-2 is involved in emotional behaviors and cognitive function
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/27954
url http://hdl.handle.net/1822/27954
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1662-5102
10.3389/fncel.2013.00122
http://www.frontiersin.org/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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