Alternative mechanisms of mRNA translationiInitiation in cellular stress response and cancer

Detalhes bibliográficos
Autor(a) principal: Lacerda, Rafaela
Data de Publicação: 2019
Outros Autores: Menezes, Juliane, Candeias, Marco M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/6468
Resumo: Throughout evolution, eukaryotic cells have devised different mechanisms to cope with stressful environments. When eukaryotic cells are exposed to stress stimuli, they activate adaptive pathways that allow them to restore cellular homeostasis. Most types of stress stimuli have been reported to induce a decrease in overall protein synthesis accompanied by induction of alternative mechanisms of mRNA translation initiation. Here, we present well-studied and recent examples of such stress responses and the alternative translation initiation mechanisms they induce, and discuss the consequences of such regulation for cell homeostasis and oncogenic transformation.
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spelling Alternative mechanisms of mRNA translationiInitiation in cellular stress response and cancerAlternative Translation InitiationCancerCellular StressIRESNon-AUGmRNA Translation.Doenças GenéticasGenómica Funcional e EstruturalThroughout evolution, eukaryotic cells have devised different mechanisms to cope with stressful environments. When eukaryotic cells are exposed to stress stimuli, they activate adaptive pathways that allow them to restore cellular homeostasis. Most types of stress stimuli have been reported to induce a decrease in overall protein synthesis accompanied by induction of alternative mechanisms of mRNA translation initiation. Here, we present well-studied and recent examples of such stress responses and the alternative translation initiation mechanisms they induce, and discuss the consequences of such regulation for cell homeostasis and oncogenic transformation.Marco M Candeias was partially supported by grants PTDC/MED-ONC/32048/2017 and PTDC/BIMONC/4890/2014 from Fundação para a Ciência e a Tecnologia (FCT), by Grants-in-Aid 16K21111 and 18K07229 from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan, by Takeda Foundation and Astellas Foundation. Juliane Menezes is a posdoc fellow (SFRH/BPD/98360/2013) from FCT.Springer VerlagRepositório Científico do Instituto Nacional de SaúdeLacerda, RafaelaMenezes, JulianeCandeias, Marco M.2020-04-21T15:32:40Z2019-08-072019-08-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6468engAdv Exp Med Biol. 2019;1157:117-132. doi: 10.1007/978-3-030-19966-1_60065-259810.1007/978-3-030-19966-1_6info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:35Zoai:repositorio.insa.pt:10400.18/6468Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:22.256639Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Alternative mechanisms of mRNA translationiInitiation in cellular stress response and cancer
title Alternative mechanisms of mRNA translationiInitiation in cellular stress response and cancer
spellingShingle Alternative mechanisms of mRNA translationiInitiation in cellular stress response and cancer
Lacerda, Rafaela
Alternative Translation Initiation
Cancer
Cellular Stress
IRES
Non-AUG
mRNA Translation.
Doenças Genéticas
Genómica Funcional e Estrutural
title_short Alternative mechanisms of mRNA translationiInitiation in cellular stress response and cancer
title_full Alternative mechanisms of mRNA translationiInitiation in cellular stress response and cancer
title_fullStr Alternative mechanisms of mRNA translationiInitiation in cellular stress response and cancer
title_full_unstemmed Alternative mechanisms of mRNA translationiInitiation in cellular stress response and cancer
title_sort Alternative mechanisms of mRNA translationiInitiation in cellular stress response and cancer
author Lacerda, Rafaela
author_facet Lacerda, Rafaela
Menezes, Juliane
Candeias, Marco M.
author_role author
author2 Menezes, Juliane
Candeias, Marco M.
author2_role author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Lacerda, Rafaela
Menezes, Juliane
Candeias, Marco M.
dc.subject.por.fl_str_mv Alternative Translation Initiation
Cancer
Cellular Stress
IRES
Non-AUG
mRNA Translation.
Doenças Genéticas
Genómica Funcional e Estrutural
topic Alternative Translation Initiation
Cancer
Cellular Stress
IRES
Non-AUG
mRNA Translation.
Doenças Genéticas
Genómica Funcional e Estrutural
description Throughout evolution, eukaryotic cells have devised different mechanisms to cope with stressful environments. When eukaryotic cells are exposed to stress stimuli, they activate adaptive pathways that allow them to restore cellular homeostasis. Most types of stress stimuli have been reported to induce a decrease in overall protein synthesis accompanied by induction of alternative mechanisms of mRNA translation initiation. Here, we present well-studied and recent examples of such stress responses and the alternative translation initiation mechanisms they induce, and discuss the consequences of such regulation for cell homeostasis and oncogenic transformation.
publishDate 2019
dc.date.none.fl_str_mv 2019-08-07
2019-08-07T00:00:00Z
2020-04-21T15:32:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/6468
url http://hdl.handle.net/10400.18/6468
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Adv Exp Med Biol. 2019;1157:117-132. doi: 10.1007/978-3-030-19966-1_6
0065-2598
10.1007/978-3-030-19966-1_6
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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