Reninoma: A Rare Cause of Endocrine Hypertension
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660 |
Resumo: | Juxtaglomerular tumours are rare causes of secondary hypertension. They typically present with difficult-to-manage hypertension, hypokalemia, hyperreninemia and secondary hyperaldosteronism. The authors describe a clinical case of a 45 years old female patient, with personal history of difficult-to-manage hypertension and hypokalemia since age 35, medicated with four types of anti-hypertensive agents. An analytical study was performed, which revealed secondary hyperaldosteronism [aldosterone 44.3 ng/dL (4 – 28 ng/dL), renin > 1000 mIU/mL (4.4 – 46.2 mIU/mL)]. Abdominal computed tomography scan identified a heterogeneous nodule located in the middle third of the right kidney, with 3.7 cm. Partial nephrectomy was performed and histological analysis confirmed the diagnosis of reninoma. After surgery, the patient had normal levels of aldosterone (9.2 ng/dL) and renin (1.20 mIU/mL), as well as normal blood pressure. The authors want to highlight this potentially curable cause of endocrine hypertension. Surgical resection is the treatment of choice and leads to normalization of blood pressure. |
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Reninoma: A Rare Cause of Endocrine HypertensionReninoma: Uma Causa Rara de Hipertensão EndócrinaAldosteroneHypertension/etiologyJuxtaglomerular ApparatusKidney NeoplasmsReninAldosteronaHipertensão/etiologiaNeoplasias do RimReninaSistema JustaglomerularJuxtaglomerular tumours are rare causes of secondary hypertension. They typically present with difficult-to-manage hypertension, hypokalemia, hyperreninemia and secondary hyperaldosteronism. The authors describe a clinical case of a 45 years old female patient, with personal history of difficult-to-manage hypertension and hypokalemia since age 35, medicated with four types of anti-hypertensive agents. An analytical study was performed, which revealed secondary hyperaldosteronism [aldosterone 44.3 ng/dL (4 – 28 ng/dL), renin > 1000 mIU/mL (4.4 – 46.2 mIU/mL)]. Abdominal computed tomography scan identified a heterogeneous nodule located in the middle third of the right kidney, with 3.7 cm. Partial nephrectomy was performed and histological analysis confirmed the diagnosis of reninoma. After surgery, the patient had normal levels of aldosterone (9.2 ng/dL) and renin (1.20 mIU/mL), as well as normal blood pressure. The authors want to highlight this potentially curable cause of endocrine hypertension. Surgical resection is the treatment of choice and leads to normalization of blood pressure.Os tumores justa-glomerulares são causas raras de hipertensão arterial de difícil controlo e cursam habitualmente com hipocaliémia, hiperreninémia e hiperaldosteronismo secundário. Descreve-se o caso de uma doente, de 45 anos, com história pessoal de hipertensão arterial de difícil controlo associada a hipocaliémia desde os 35 anos, medicada com quatro classes de anti-hipertensores. Do estudo realizado destaca-se hiperaldosteronismo secundário [aldosterona 44,3 ng/dL (4 - 28 ng/dL), renina > 1000 mUI/mL (4,4 - 46,16 mUI/mL)] e tomografia axial computorizada, que identificou formação nodular heterogénea localizada no terço médio do rim direito, com 3,7 cm de diâmetro. Foi realizada nefrectomia parcial, cuja análise histológica confirmou o diagnóstico de reninoma. Após a cirurgia, verificou-se normalização dos doseamentos hormonais (aldosterona 9,2 ng/dL; renina 1,20 mUI/mL) e da pressão arterial. Pretende-se chamar a atenção para esta causa potencialmente curável de hipertensão arterial endócrina. A ressecção cirúrgica é o tratamento de escolha e leva à normalização da pressão arterial.Ordem dos Médicos2020-12-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfimage/pngimage/pngapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfimage/jpegimage/jpegimage/jpegimage/jpegapplication/mswordapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660oai:ojs.www.actamedicaportuguesa.com:article/11660Acta Médica Portuguesa; Vol. 33 No. 12 (2020): December; 835-838Acta Médica Portuguesa; Vol. 33 N.º 12 (2020): Dezembro; 835-8381646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660/5705https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660/10982https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660/10983https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660/10984https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660/10985https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660/10986https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660/10987https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660/10988https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660/10989https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660/11012https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660/11013https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660/11014https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660/11231https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660/11407https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660/11422Direitos de Autor (c) 2019 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessMarques, BernardoCouto, JoanaLemos, Manuel C.Rodrigues, Fernando2022-12-20T11:06:18Zoai:ojs.www.actamedicaportuguesa.com:article/11660Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:20:04.217381Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Reninoma: A Rare Cause of Endocrine Hypertension Reninoma: Uma Causa Rara de Hipertensão Endócrina |
title |
Reninoma: A Rare Cause of Endocrine Hypertension |
spellingShingle |
Reninoma: A Rare Cause of Endocrine Hypertension Marques, Bernardo Aldosterone Hypertension/etiology Juxtaglomerular Apparatus Kidney Neoplasms Renin Aldosterona Hipertensão/etiologia Neoplasias do Rim Renina Sistema Justaglomerular |
title_short |
Reninoma: A Rare Cause of Endocrine Hypertension |
title_full |
Reninoma: A Rare Cause of Endocrine Hypertension |
title_fullStr |
Reninoma: A Rare Cause of Endocrine Hypertension |
title_full_unstemmed |
Reninoma: A Rare Cause of Endocrine Hypertension |
title_sort |
Reninoma: A Rare Cause of Endocrine Hypertension |
author |
Marques, Bernardo |
author_facet |
Marques, Bernardo Couto, Joana Lemos, Manuel C. Rodrigues, Fernando |
author_role |
author |
author2 |
Couto, Joana Lemos, Manuel C. Rodrigues, Fernando |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Marques, Bernardo Couto, Joana Lemos, Manuel C. Rodrigues, Fernando |
dc.subject.por.fl_str_mv |
Aldosterone Hypertension/etiology Juxtaglomerular Apparatus Kidney Neoplasms Renin Aldosterona Hipertensão/etiologia Neoplasias do Rim Renina Sistema Justaglomerular |
topic |
Aldosterone Hypertension/etiology Juxtaglomerular Apparatus Kidney Neoplasms Renin Aldosterona Hipertensão/etiologia Neoplasias do Rim Renina Sistema Justaglomerular |
description |
Juxtaglomerular tumours are rare causes of secondary hypertension. They typically present with difficult-to-manage hypertension, hypokalemia, hyperreninemia and secondary hyperaldosteronism. The authors describe a clinical case of a 45 years old female patient, with personal history of difficult-to-manage hypertension and hypokalemia since age 35, medicated with four types of anti-hypertensive agents. An analytical study was performed, which revealed secondary hyperaldosteronism [aldosterone 44.3 ng/dL (4 – 28 ng/dL), renin > 1000 mIU/mL (4.4 – 46.2 mIU/mL)]. Abdominal computed tomography scan identified a heterogeneous nodule located in the middle third of the right kidney, with 3.7 cm. Partial nephrectomy was performed and histological analysis confirmed the diagnosis of reninoma. After surgery, the patient had normal levels of aldosterone (9.2 ng/dL) and renin (1.20 mIU/mL), as well as normal blood pressure. The authors want to highlight this potentially curable cause of endocrine hypertension. Surgical resection is the treatment of choice and leads to normalization of blood pressure. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-02 |
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info:eu-repo/semantics/article |
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article |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660 oai:ojs.www.actamedicaportuguesa.com:article/11660 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660 |
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Direitos de Autor (c) 2019 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
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Acta Médica Portuguesa; Vol. 33 No. 12 (2020): December; 835-838 Acta Médica Portuguesa; Vol. 33 N.º 12 (2020): Dezembro; 835-838 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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