Photodynamic therapy review: principles, photosensitizers, applications, and future directions

Detalhes bibliográficos
Autor(a) principal: Correia, J. H.
Data de Publicação: 2021
Outros Autores: Rodrigues, José Artur Oliveira, Pimenta, Sara Filomena Ribeiro, Dong, Tao, Yang, Zhaochu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/74805
Resumo: "This article belongs to the Special Issue: Special Issue in Honor of Dr. Michael Weber’s 70th Birthday: Photodynamic Therapy: Rising Star in Pharmaceutical Applications"
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spelling Photodynamic therapy review: principles, photosensitizers, applications, and future directionsPDT mechanismsNew photosensitizersPDT tumor treatmentAntimicrobial PDTNon-oncologic applications of PDTPDT in medical devicesScience & Technology"This article belongs to the Special Issue: Special Issue in Honor of Dr. Michael Weber’s 70th Birthday: Photodynamic Therapy: Rising Star in Pharmaceutical Applications"Photodynamic therapy (PDT) is a minimally invasive therapeutic modality that has gained great attention in the past years as a new therapy for cancer treatment. PDT uses photosensitizers that, after being excited by light at a specific wavelength, react with the molecular oxygen to create reactive oxygen species in the target tissue, resulting in cell death. Compared to conventional therapeutic modalities, PDT presents greater selectivity against tumor cells, due to the use of photosensitizers that are preferably localized in tumor lesions, and the precise light irradiation of these lesions. This paper presents a review of the principles, mechanisms, photosensitizers, and current applications of PDT. Moreover, the future path on the research of new photosensitizers with enhanced tumor selectivity, featuring the improvement of PDT effectiveness, has also been addressed. Finally, new applications of PDT have been covered.This work was supported by FCT with project OpticalBrain reference PTDC/CTMREF/28406/2017, operation code POCI-01-0145-FEDER-028406, through the COMPETE 2020; CMEMSUMinho Strategic Project UIDB/04436/2020; Infrastructures Micro&NanoFabs@PT, operation code NORTE 01-0145-FEDER-022090, POR Norte, Portugal 2020; and MPhotonBiopsy, PTDC/FIS-OTI/1259/2020. The authors thank Biolitec research GmbH (Jena, Germany) for providing the photosensitizer Foscan®.The APC was funded by Chongqing Technology and Business University (CTBU).Multidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoCorreia, J. H.Rodrigues, José Artur OliveiraPimenta, Sara Filomena RibeiroDong, TaoYang, Zhaochu2021-08-252021-08-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/74805engCorreia, J.H.; Rodrigues, J.A.; Pimenta, S.; Dong, T.; Yang, Z. Photodynamic Therapy Review: Principles, Photosensitizers, Applications, and Future Directions. Pharmaceutics 2021, 13, 1332. https://doi.org/10.3390/pharmaceutics130913321999-492310.3390/pharmaceutics13091332https://www.mdpi.com/1999-4923/13/9/1332info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-16T01:19:45Zoai:repositorium.sdum.uminho.pt:1822/74805Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:19:17.253108Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Photodynamic therapy review: principles, photosensitizers, applications, and future directions
title Photodynamic therapy review: principles, photosensitizers, applications, and future directions
spellingShingle Photodynamic therapy review: principles, photosensitizers, applications, and future directions
Correia, J. H.
PDT mechanisms
New photosensitizers
PDT tumor treatment
Antimicrobial PDT
Non-oncologic applications of PDT
PDT in medical devices
Science & Technology
title_short Photodynamic therapy review: principles, photosensitizers, applications, and future directions
title_full Photodynamic therapy review: principles, photosensitizers, applications, and future directions
title_fullStr Photodynamic therapy review: principles, photosensitizers, applications, and future directions
title_full_unstemmed Photodynamic therapy review: principles, photosensitizers, applications, and future directions
title_sort Photodynamic therapy review: principles, photosensitizers, applications, and future directions
author Correia, J. H.
author_facet Correia, J. H.
Rodrigues, José Artur Oliveira
Pimenta, Sara Filomena Ribeiro
Dong, Tao
Yang, Zhaochu
author_role author
author2 Rodrigues, José Artur Oliveira
Pimenta, Sara Filomena Ribeiro
Dong, Tao
Yang, Zhaochu
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Correia, J. H.
Rodrigues, José Artur Oliveira
Pimenta, Sara Filomena Ribeiro
Dong, Tao
Yang, Zhaochu
dc.subject.por.fl_str_mv PDT mechanisms
New photosensitizers
PDT tumor treatment
Antimicrobial PDT
Non-oncologic applications of PDT
PDT in medical devices
Science & Technology
topic PDT mechanisms
New photosensitizers
PDT tumor treatment
Antimicrobial PDT
Non-oncologic applications of PDT
PDT in medical devices
Science & Technology
description "This article belongs to the Special Issue: Special Issue in Honor of Dr. Michael Weber’s 70th Birthday: Photodynamic Therapy: Rising Star in Pharmaceutical Applications"
publishDate 2021
dc.date.none.fl_str_mv 2021-08-25
2021-08-25T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/74805
url https://hdl.handle.net/1822/74805
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Correia, J.H.; Rodrigues, J.A.; Pimenta, S.; Dong, T.; Yang, Z. Photodynamic Therapy Review: Principles, Photosensitizers, Applications, and Future Directions. Pharmaceutics 2021, 13, 1332. https://doi.org/10.3390/pharmaceutics13091332
1999-4923
10.3390/pharmaceutics13091332
https://www.mdpi.com/1999-4923/13/9/1332
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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