Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery

Detalhes bibliográficos
Autor(a) principal: Miranda, Margarida Silva
Data de Publicação: 2018
Outros Autores: Rodrigues, Márcia T., Domingues, Rui Miguel Andrade, Torrado, Egídio, Reis, R. L., Pedrosa, Jorge, Gomes, Manuela E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/56675
Resumo: The growing interest on polymeric delivery systems for pulmonary administration of drugs anticipates a more direct and efficient treatment of diseases such as tuberculosis (TB) that uses the pulmonary route as the natural route of infection. Polymeric microparticles or nano-in-microparticles offer target delivery of drugs to the lungs and the potential to control and sustain drug release within TB infected macrophages improving the efficiency of the anti-TB treatment and reducing side effects. In a dry powder form these inhalable delivery systems have increased stability and prolonged storage time without requiring refrigeration, besides being cost-effective and patient convenient. Thus, this review aims to compile the recent innovations of inhalable polymeric dry powder systems for the delivery of anti-TB drugs exploring the methods of production, aerodynamic characterization and the efficacy of targeted drug delivery systems using in vitro and in vivo models of the disease. Advanced knowledge and promising outcomes of these systems are anticipated to simplify and revolutionize the pulmonary drug delivery and to contribute towards more effective anti-TB treatments.
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spelling Exploring inhalable polymeric dry powders for anti-tuberculosis drug deliveryPolymeric materialDry powdersMicroparticulate systemsDrug targetingAlveolar macrophagesTuberculosisPolymeric materialsScience & TechnologyThe growing interest on polymeric delivery systems for pulmonary administration of drugs anticipates a more direct and efficient treatment of diseases such as tuberculosis (TB) that uses the pulmonary route as the natural route of infection. Polymeric microparticles or nano-in-microparticles offer target delivery of drugs to the lungs and the potential to control and sustain drug release within TB infected macrophages improving the efficiency of the anti-TB treatment and reducing side effects. In a dry powder form these inhalable delivery systems have increased stability and prolonged storage time without requiring refrigeration, besides being cost-effective and patient convenient. Thus, this review aims to compile the recent innovations of inhalable polymeric dry powder systems for the delivery of anti-TB drugs exploring the methods of production, aerodynamic characterization and the efficacy of targeted drug delivery systems using in vitro and in vivo models of the disease. Advanced knowledge and promising outcomes of these systems are anticipated to simplify and revolutionize the pulmonary drug delivery and to contribute towards more effective anti-TB treatments.The authors wish to acknowledge the financial support from the Portuguese Foundation for Science and Technology (FCT) for the postdoctoral grant of M.S.M (SFRH/BPD/110868/2015), M.T.R (SFRH/BPD/111729/2015) and R.M.A.D (SFRH/BPD/112459/2015), FCT grant of E.T. (IF/01390/2014) and Recognize project (UTAP-ICDT/ CTM-BIO/0023/2014). This article is also a result of the project “Accelerating tissue engineering and personalized medicine discoveries by the integration of key enabling nanotechonologies, marine-derived biomaterials and stem cells”, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). The authors acknowledge the financial support from the European Union Framework Programme for Research and Innovation HORIZON 2020, under the TEAMING Grant agreement No 739572 - The Discoveries CTR.info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoMiranda, Margarida SilvaRodrigues, Márcia T.Domingues, Rui Miguel AndradeTorrado, EgídioReis, R. L.Pedrosa, JorgeGomes, Manuela E.2018-092018-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/56675engMiranda M. S., Rodrigues M. T., Domingues R. M. A., Torrado E., Reis R. L., Pedrosa J., Gomes M. E. Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery, Materials Science and Engineering: C, Vol. 93, Issue 1, pp. 1090-1103, doi:10.1016/j.msec.2018.09.004, 20180928-493110.1016/j.msec.2018.09.00430274040https://www.sciencedirect.com/science/article/pii/S0928493118307070info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:27:03Zoai:repositorium.sdum.uminho.pt:1822/56675Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:21:36.302994Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery
title Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery
spellingShingle Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery
Miranda, Margarida Silva
Polymeric material
Dry powders
Microparticulate systems
Drug targeting
Alveolar macrophages
Tuberculosis
Polymeric materials
Science & Technology
title_short Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery
title_full Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery
title_fullStr Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery
title_full_unstemmed Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery
title_sort Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery
author Miranda, Margarida Silva
author_facet Miranda, Margarida Silva
Rodrigues, Márcia T.
Domingues, Rui Miguel Andrade
Torrado, Egídio
Reis, R. L.
Pedrosa, Jorge
Gomes, Manuela E.
author_role author
author2 Rodrigues, Márcia T.
Domingues, Rui Miguel Andrade
Torrado, Egídio
Reis, R. L.
Pedrosa, Jorge
Gomes, Manuela E.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Miranda, Margarida Silva
Rodrigues, Márcia T.
Domingues, Rui Miguel Andrade
Torrado, Egídio
Reis, R. L.
Pedrosa, Jorge
Gomes, Manuela E.
dc.subject.por.fl_str_mv Polymeric material
Dry powders
Microparticulate systems
Drug targeting
Alveolar macrophages
Tuberculosis
Polymeric materials
Science & Technology
topic Polymeric material
Dry powders
Microparticulate systems
Drug targeting
Alveolar macrophages
Tuberculosis
Polymeric materials
Science & Technology
description The growing interest on polymeric delivery systems for pulmonary administration of drugs anticipates a more direct and efficient treatment of diseases such as tuberculosis (TB) that uses the pulmonary route as the natural route of infection. Polymeric microparticles or nano-in-microparticles offer target delivery of drugs to the lungs and the potential to control and sustain drug release within TB infected macrophages improving the efficiency of the anti-TB treatment and reducing side effects. In a dry powder form these inhalable delivery systems have increased stability and prolonged storage time without requiring refrigeration, besides being cost-effective and patient convenient. Thus, this review aims to compile the recent innovations of inhalable polymeric dry powder systems for the delivery of anti-TB drugs exploring the methods of production, aerodynamic characterization and the efficacy of targeted drug delivery systems using in vitro and in vivo models of the disease. Advanced knowledge and promising outcomes of these systems are anticipated to simplify and revolutionize the pulmonary drug delivery and to contribute towards more effective anti-TB treatments.
publishDate 2018
dc.date.none.fl_str_mv 2018-09
2018-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/56675
url http://hdl.handle.net/1822/56675
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Miranda M. S., Rodrigues M. T., Domingues R. M. A., Torrado E., Reis R. L., Pedrosa J., Gomes M. E. Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery, Materials Science and Engineering: C, Vol. 93, Issue 1, pp. 1090-1103, doi:10.1016/j.msec.2018.09.004, 2018
0928-4931
10.1016/j.msec.2018.09.004
30274040
https://www.sciencedirect.com/science/article/pii/S0928493118307070
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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