Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences

Detalhes bibliográficos
Autor(a) principal: Coll, Francesc
Data de Publicação: 2015
Outros Autores: McNerney, Ruth, Preston, Mark D., Guerra-Assunção, José Afonso, Warry, Andrew, Hill-Cawthorne, Grant, Mallard, Kim, Nair, Mridul, Miranda, Anabela, Alves, Adriana, Perdigão, João, Viveiros, Miguel, Portugal, Isabel, Hasan, Zahra, Hasan, Rumina, Glynn, Judith R., Martin, Nigel, Pain, Arnab, Clark, Taane G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.1186/s13073-015-0164-0
Resumo: PMID: 26019726 WOS:000355073700001
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spelling Rapid determination of anti-tuberculosis drug resistance from whole-genome sequencesGenetics(clinical)GeneticsMolecular BiologyMolecular MedicineSDG 3 - Good Health and Well-beingPMID: 26019726 WOS:000355073700001Mycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease control. Current molecular tests examine limited numbers of mutations, and although whole genome sequencing approaches could fully characterise DR, data complexity has restricted their clinical application. A library (1,325 mutations) predictive of DR for 15 anti-tuberculosis drugs was compiled and validated for 11 of them using genomic-phenotypic data from 792 strains. A rapid online 'TB-Profiler' tool was developed to report DR and strain-type profiles directly from raw sequences. Using our DR mutation library, in silico diagnostic accuracy was superior to some commercial diagnostics and alternative databases. The library will facilitate sequence-based drug-susceptibility testing.Instituto de Higiene e Medicina Tropical (IHMT)TB, HIV and opportunistic diseases and pathogens (THOP)Global Health and Tropical Medicine (GHTM)RUNColl, FrancescMcNerney, RuthPreston, Mark D.Guerra-Assunção, José AfonsoWarry, AndrewHill-Cawthorne, GrantMallard, KimNair, MridulMiranda, AnabelaAlves, AdrianaPerdigão, JoãoViveiros, MiguelPortugal, IsabelHasan, ZahraHasan, RuminaGlynn, Judith R.Martin, NigelPain, ArnabClark, Taane G.2018-05-14T22:01:34Z2015-05-272015-05-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1186/s13073-015-0164-0eng1756-994XPURE: 1645018http://www.scopus.com/inward/record.url?scp=84939257684&partnerID=8YFLogxKhttps://doi.org/10.1186/s13073-015-0164-0info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:20:27Zoai:run.unl.pt:10362/36926Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:30:42.155031Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
title Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
spellingShingle Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
Coll, Francesc
Genetics(clinical)
Genetics
Molecular Biology
Molecular Medicine
SDG 3 - Good Health and Well-being
title_short Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
title_full Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
title_fullStr Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
title_full_unstemmed Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
title_sort Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
author Coll, Francesc
author_facet Coll, Francesc
McNerney, Ruth
Preston, Mark D.
Guerra-Assunção, José Afonso
Warry, Andrew
Hill-Cawthorne, Grant
Mallard, Kim
Nair, Mridul
Miranda, Anabela
Alves, Adriana
Perdigão, João
Viveiros, Miguel
Portugal, Isabel
Hasan, Zahra
Hasan, Rumina
Glynn, Judith R.
Martin, Nigel
Pain, Arnab
Clark, Taane G.
author_role author
author2 McNerney, Ruth
Preston, Mark D.
Guerra-Assunção, José Afonso
Warry, Andrew
Hill-Cawthorne, Grant
Mallard, Kim
Nair, Mridul
Miranda, Anabela
Alves, Adriana
Perdigão, João
Viveiros, Miguel
Portugal, Isabel
Hasan, Zahra
Hasan, Rumina
Glynn, Judith R.
Martin, Nigel
Pain, Arnab
Clark, Taane G.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Higiene e Medicina Tropical (IHMT)
TB, HIV and opportunistic diseases and pathogens (THOP)
Global Health and Tropical Medicine (GHTM)
RUN
dc.contributor.author.fl_str_mv Coll, Francesc
McNerney, Ruth
Preston, Mark D.
Guerra-Assunção, José Afonso
Warry, Andrew
Hill-Cawthorne, Grant
Mallard, Kim
Nair, Mridul
Miranda, Anabela
Alves, Adriana
Perdigão, João
Viveiros, Miguel
Portugal, Isabel
Hasan, Zahra
Hasan, Rumina
Glynn, Judith R.
Martin, Nigel
Pain, Arnab
Clark, Taane G.
dc.subject.por.fl_str_mv Genetics(clinical)
Genetics
Molecular Biology
Molecular Medicine
SDG 3 - Good Health and Well-being
topic Genetics(clinical)
Genetics
Molecular Biology
Molecular Medicine
SDG 3 - Good Health and Well-being
description PMID: 26019726 WOS:000355073700001
publishDate 2015
dc.date.none.fl_str_mv 2015-05-27
2015-05-27T00:00:00Z
2018-05-14T22:01:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1186/s13073-015-0164-0
url https://doi.org/10.1186/s13073-015-0164-0
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1756-994X
PURE: 1645018
http://www.scopus.com/inward/record.url?scp=84939257684&partnerID=8YFLogxK
https://doi.org/10.1186/s13073-015-0164-0
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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