Human immunodeficiency virus and carotid artery disease – single center experience and literature review

Detalhes bibliográficos
Autor(a) principal: Pereira-Neves, António
Data de Publicação: 2022
Outros Autores: Pereira-Macedo, Juliana, Soares, Tiago, Duarte-Gamas, Luís, Jácome, Filipa, Nóbrega, Leandro, Dias-Neto, Marina, Rocha-Neves, João, Cerqueira, Alfredo, Teixeira, José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.48750/acv.408
Resumo: INTRODUCTION: People infected with the human immunodeficiency virus (HIV) - People living with HIV/AIDS (PLWHA) - seem to have an increased risk of incidence and prevalence of cardiovascular diseases, namely stroke of ischemic nature. Additional etiological mechanisms, in addition to aging, appear to lie in chronic virus-mediated inflammation as well as in antiretroviral therapy (ART). The aim of this study was to carry out a retrospective review with descriptive analysis of cases of PLWHA and with a diagnosis of carotid atherosclerotic disease in a tertiary referral center as well as a non-systematic review of the literature. METHODS: All patients diagnosed with HIV infection and concomitantly diagnosed with carotid atherosclerotic disease, in a tertiary center, between October 2007 and December 2019, were selected. A descriptive analysis of the sample and additionally a non-systematic review of the literature using the MEDLINE database, were performed. RESULTS: Nine patients who met the inclusion criteria were selected, 7 (78%) being male. The mean age at diagnosis of carotid disease was 59 years. The diagnosis of HIV infection preceded, on average, 12 years before the diagnosis of carotid disease, while the start of ART preceded this diagnosis by about 11 years. The most common cardiovascular risk factors are dyslipidemia (89%), high blood pressure (56%) and smoking (56%). Approximately 33% had peripheral arterial disease and 22% had coronary artery disease. Only two (22%) patients underwent carotid endarterectomy over a median follow-up of 5 years, both for asymptomatic stenosis. Since the diagnosis of carotid disease, there have been no major cardiovascular events (stroke or acute myocardial infarction). During follow-up there were two deaths. CONCLUSION: PLWHA have a high prevalence of multisite artery disease, manifesting it at a relatively earlier age compared to the general population. These patients benefit from multidisciplinary follow-up for therapeutic optimization in order to obtain better results. However, larger prospective studies are needed to clarify the results in these patients and to improve the therapeutic approach, particularly in those with concomitant carotid disease.
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spelling Human immunodeficiency virus and carotid artery disease – single center experience and literature reviewHIVAIDScarotid artery diseasecarotid endarterectomyINTRODUCTION: People infected with the human immunodeficiency virus (HIV) - People living with HIV/AIDS (PLWHA) - seem to have an increased risk of incidence and prevalence of cardiovascular diseases, namely stroke of ischemic nature. Additional etiological mechanisms, in addition to aging, appear to lie in chronic virus-mediated inflammation as well as in antiretroviral therapy (ART). The aim of this study was to carry out a retrospective review with descriptive analysis of cases of PLWHA and with a diagnosis of carotid atherosclerotic disease in a tertiary referral center as well as a non-systematic review of the literature. METHODS: All patients diagnosed with HIV infection and concomitantly diagnosed with carotid atherosclerotic disease, in a tertiary center, between October 2007 and December 2019, were selected. A descriptive analysis of the sample and additionally a non-systematic review of the literature using the MEDLINE database, were performed. RESULTS: Nine patients who met the inclusion criteria were selected, 7 (78%) being male. The mean age at diagnosis of carotid disease was 59 years. The diagnosis of HIV infection preceded, on average, 12 years before the diagnosis of carotid disease, while the start of ART preceded this diagnosis by about 11 years. The most common cardiovascular risk factors are dyslipidemia (89%), high blood pressure (56%) and smoking (56%). Approximately 33% had peripheral arterial disease and 22% had coronary artery disease. Only two (22%) patients underwent carotid endarterectomy over a median follow-up of 5 years, both for asymptomatic stenosis. Since the diagnosis of carotid disease, there have been no major cardiovascular events (stroke or acute myocardial infarction). During follow-up there were two deaths. CONCLUSION: PLWHA have a high prevalence of multisite artery disease, manifesting it at a relatively earlier age compared to the general population. These patients benefit from multidisciplinary follow-up for therapeutic optimization in order to obtain better results. However, larger prospective studies are needed to clarify the results in these patients and to improve the therapeutic approach, particularly in those with concomitant carotid disease.Sociedade Portuguesa de Angiologia e Cirurgia Vascular2022-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.48750/acv.408oai:ojs.acvjournal.com:article/408Angiologia e Cirurgia Vascular; Vol. 18 No. 1 (2022): March; 17-29Angiologia e Cirurgia Vascular; Vol. 18 N.º 1 (2022): Março; 17-292183-00961646-706Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://acvjournal.com/index.php/acv/article/view/408https://doi.org/10.48750/acv.408http://acvjournal.com/index.php/acv/article/view/408/283Copyright (c) 2022 Angiologia e Cirurgia Vascularinfo:eu-repo/semantics/openAccessPereira-Neves, AntónioPereira-Macedo, JulianaSoares, TiagoDuarte-Gamas, LuísJácome, FilipaNóbrega, LeandroDias-Neto, MarinaRocha-Neves, JoãoCerqueira, AlfredoTeixeira, José2022-07-08T10:30:20Zoai:ojs.acvjournal.com:article/408Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T14:59:49.498005Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Human immunodeficiency virus and carotid artery disease – single center experience and literature review
title Human immunodeficiency virus and carotid artery disease – single center experience and literature review
spellingShingle Human immunodeficiency virus and carotid artery disease – single center experience and literature review
Pereira-Neves, António
HIV
AIDS
carotid artery disease
carotid endarterectomy
title_short Human immunodeficiency virus and carotid artery disease – single center experience and literature review
title_full Human immunodeficiency virus and carotid artery disease – single center experience and literature review
title_fullStr Human immunodeficiency virus and carotid artery disease – single center experience and literature review
title_full_unstemmed Human immunodeficiency virus and carotid artery disease – single center experience and literature review
title_sort Human immunodeficiency virus and carotid artery disease – single center experience and literature review
author Pereira-Neves, António
author_facet Pereira-Neves, António
Pereira-Macedo, Juliana
Soares, Tiago
Duarte-Gamas, Luís
Jácome, Filipa
Nóbrega, Leandro
Dias-Neto, Marina
Rocha-Neves, João
Cerqueira, Alfredo
Teixeira, José
author_role author
author2 Pereira-Macedo, Juliana
Soares, Tiago
Duarte-Gamas, Luís
Jácome, Filipa
Nóbrega, Leandro
Dias-Neto, Marina
Rocha-Neves, João
Cerqueira, Alfredo
Teixeira, José
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira-Neves, António
Pereira-Macedo, Juliana
Soares, Tiago
Duarte-Gamas, Luís
Jácome, Filipa
Nóbrega, Leandro
Dias-Neto, Marina
Rocha-Neves, João
Cerqueira, Alfredo
Teixeira, José
dc.subject.por.fl_str_mv HIV
AIDS
carotid artery disease
carotid endarterectomy
topic HIV
AIDS
carotid artery disease
carotid endarterectomy
description INTRODUCTION: People infected with the human immunodeficiency virus (HIV) - People living with HIV/AIDS (PLWHA) - seem to have an increased risk of incidence and prevalence of cardiovascular diseases, namely stroke of ischemic nature. Additional etiological mechanisms, in addition to aging, appear to lie in chronic virus-mediated inflammation as well as in antiretroviral therapy (ART). The aim of this study was to carry out a retrospective review with descriptive analysis of cases of PLWHA and with a diagnosis of carotid atherosclerotic disease in a tertiary referral center as well as a non-systematic review of the literature. METHODS: All patients diagnosed with HIV infection and concomitantly diagnosed with carotid atherosclerotic disease, in a tertiary center, between October 2007 and December 2019, were selected. A descriptive analysis of the sample and additionally a non-systematic review of the literature using the MEDLINE database, were performed. RESULTS: Nine patients who met the inclusion criteria were selected, 7 (78%) being male. The mean age at diagnosis of carotid disease was 59 years. The diagnosis of HIV infection preceded, on average, 12 years before the diagnosis of carotid disease, while the start of ART preceded this diagnosis by about 11 years. The most common cardiovascular risk factors are dyslipidemia (89%), high blood pressure (56%) and smoking (56%). Approximately 33% had peripheral arterial disease and 22% had coronary artery disease. Only two (22%) patients underwent carotid endarterectomy over a median follow-up of 5 years, both for asymptomatic stenosis. Since the diagnosis of carotid disease, there have been no major cardiovascular events (stroke or acute myocardial infarction). During follow-up there were two deaths. CONCLUSION: PLWHA have a high prevalence of multisite artery disease, manifesting it at a relatively earlier age compared to the general population. These patients benefit from multidisciplinary follow-up for therapeutic optimization in order to obtain better results. However, larger prospective studies are needed to clarify the results in these patients and to improve the therapeutic approach, particularly in those with concomitant carotid disease.
publishDate 2022
dc.date.none.fl_str_mv 2022-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.48750/acv.408
oai:ojs.acvjournal.com:article/408
url https://doi.org/10.48750/acv.408
identifier_str_mv oai:ojs.acvjournal.com:article/408
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://acvjournal.com/index.php/acv/article/view/408
https://doi.org/10.48750/acv.408
http://acvjournal.com/index.php/acv/article/view/408/283
dc.rights.driver.fl_str_mv Copyright (c) 2022 Angiologia e Cirurgia Vascular
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Angiologia e Cirurgia Vascular
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Angiologia e Cirurgia Vascular
publisher.none.fl_str_mv Sociedade Portuguesa de Angiologia e Cirurgia Vascular
dc.source.none.fl_str_mv Angiologia e Cirurgia Vascular; Vol. 18 No. 1 (2022): March; 17-29
Angiologia e Cirurgia Vascular; Vol. 18 N.º 1 (2022): Março; 17-29
2183-0096
1646-706X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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