Schiff bases complexed with iron and their relation with the life cycle and infection by Schistosoma mansoni
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/147861 |
Resumo: | Funding Information: This work was supported by the Support Foundation of São Paulo (FAPESP) [No. 2014/12568-4] and National Counsel of Technological and Scientific Development (CNPq) [No. 100763/2015-4] received by JV da Silva. Acknowledgments Publisher Copyright: Copyright © 2022 da Silva, Moreira, Montija, Feitosa, Correia, Domingues, Soares, Allegretti, Afonso and Anibal. |
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Schiff bases complexed with iron and their relation with the life cycle and infection by Schistosoma mansoniBALB/cBiomphalaria glabratain vivo – in vitroinflammationschistosomicidal activityRM Therapeutics. PharmacologyQ ScienceRA0421 Public health. Hygiene. Preventive MedicineImmunology and AllergyImmunologySDG 3 - Good Health and Well-beingSDG 6 - Clean Water and SanitationSDG 14 - Life Below WaterFunding Information: This work was supported by the Support Foundation of São Paulo (FAPESP) [No. 2014/12568-4] and National Counsel of Technological and Scientific Development (CNPq) [No. 100763/2015-4] received by JV da Silva. Acknowledgments Publisher Copyright: Copyright © 2022 da Silva, Moreira, Montija, Feitosa, Correia, Domingues, Soares, Allegretti, Afonso and Anibal.Introduction: The trematode Schistosoma mansoni causes schistosomiasis, and this parasite’s life cycle depends on the mollusk Biomphalaria glabrata. The most effective treatment for infected people is administering a single dose of Praziquantel. However, there are naturally resistant to treatment. This work has developed, considering this parasite’s complex life cycle. Methods: The synthetics compound were evaluated: i) during the infection of B. glabrata, ii) during the infection of BALB/c mice, and iii) during the treatment of mice infected with S. mansoni. Results and Discussion: For the first objective, snails infected with miracidia treated with compounds C1 and C3 at concentrations of 25% IC50 and 50% IC50, after 80 days of infection, released fewer cercariae than the infected group without treatment. For the second objective, compounds C1 and C3 did not show significant results in the infected group without treatment. For the third objective, the mice treated with C3 and C1 reduced the global and differential cell count. The results suggest that although the evaluated compounds do not present schistosomicidal properties when placed in cercariae suspension, they can stimulate an immune reaction in snails and decrease mice’s inflammatory response. In general, we can conclude that compound C1 and C3 has an anti-schistosomicidal effect both in the larval phase (miracidia) and in the adult form of the parasite.Instituto de Higiene e Medicina Tropical (IHMT)Vector borne diseases and pathogens (VBD)Global Health and Tropical Medicine (GHTM)Universidade NOVA de LisboaRUNda Silva, Juliana VirginioMoreira, Carla CristinaMontija, Elisandra de AlmeidaFeitosa, Karina AlvesCorreia, Ricardo de OliveiraDomingues, Nelson Luis de CamposSoares, Edson GarciaAllegretti, Silmara MarquesAfonso, AnaAnibal, Fernanda de Freitas2023-01-19T22:18:55Z2022-12-212022-12-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/147861eng1664-3224PURE: 50457721https://doi.org/10.3389/fimmu.2022.1021768info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:08:20Zoai:run.unl.pt:10362/147861Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:08:20Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Schiff bases complexed with iron and their relation with the life cycle and infection by Schistosoma mansoni |
| title |
Schiff bases complexed with iron and their relation with the life cycle and infection by Schistosoma mansoni |
| spellingShingle |
Schiff bases complexed with iron and their relation with the life cycle and infection by Schistosoma mansoni da Silva, Juliana Virginio BALB/c Biomphalaria glabrata in vivo – in vitro inflammation schistosomicidal activity RM Therapeutics. Pharmacology Q Science RA0421 Public health. Hygiene. Preventive Medicine Immunology and Allergy Immunology SDG 3 - Good Health and Well-being SDG 6 - Clean Water and Sanitation SDG 14 - Life Below Water |
| title_short |
Schiff bases complexed with iron and their relation with the life cycle and infection by Schistosoma mansoni |
| title_full |
Schiff bases complexed with iron and their relation with the life cycle and infection by Schistosoma mansoni |
| title_fullStr |
Schiff bases complexed with iron and their relation with the life cycle and infection by Schistosoma mansoni |
| title_full_unstemmed |
Schiff bases complexed with iron and their relation with the life cycle and infection by Schistosoma mansoni |
| title_sort |
Schiff bases complexed with iron and their relation with the life cycle and infection by Schistosoma mansoni |
| author |
da Silva, Juliana Virginio |
| author_facet |
da Silva, Juliana Virginio Moreira, Carla Cristina Montija, Elisandra de Almeida Feitosa, Karina Alves Correia, Ricardo de Oliveira Domingues, Nelson Luis de Campos Soares, Edson Garcia Allegretti, Silmara Marques Afonso, Ana Anibal, Fernanda de Freitas |
| author_role |
author |
| author2 |
Moreira, Carla Cristina Montija, Elisandra de Almeida Feitosa, Karina Alves Correia, Ricardo de Oliveira Domingues, Nelson Luis de Campos Soares, Edson Garcia Allegretti, Silmara Marques Afonso, Ana Anibal, Fernanda de Freitas |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Vector borne diseases and pathogens (VBD) Global Health and Tropical Medicine (GHTM) Universidade NOVA de Lisboa RUN |
| dc.contributor.author.fl_str_mv |
da Silva, Juliana Virginio Moreira, Carla Cristina Montija, Elisandra de Almeida Feitosa, Karina Alves Correia, Ricardo de Oliveira Domingues, Nelson Luis de Campos Soares, Edson Garcia Allegretti, Silmara Marques Afonso, Ana Anibal, Fernanda de Freitas |
| dc.subject.por.fl_str_mv |
BALB/c Biomphalaria glabrata in vivo – in vitro inflammation schistosomicidal activity RM Therapeutics. Pharmacology Q Science RA0421 Public health. Hygiene. Preventive Medicine Immunology and Allergy Immunology SDG 3 - Good Health and Well-being SDG 6 - Clean Water and Sanitation SDG 14 - Life Below Water |
| topic |
BALB/c Biomphalaria glabrata in vivo – in vitro inflammation schistosomicidal activity RM Therapeutics. Pharmacology Q Science RA0421 Public health. Hygiene. Preventive Medicine Immunology and Allergy Immunology SDG 3 - Good Health and Well-being SDG 6 - Clean Water and Sanitation SDG 14 - Life Below Water |
| description |
Funding Information: This work was supported by the Support Foundation of São Paulo (FAPESP) [No. 2014/12568-4] and National Counsel of Technological and Scientific Development (CNPq) [No. 100763/2015-4] received by JV da Silva. Acknowledgments Publisher Copyright: Copyright © 2022 da Silva, Moreira, Montija, Feitosa, Correia, Domingues, Soares, Allegretti, Afonso and Anibal. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-12-21 2022-12-21T00:00:00Z 2023-01-19T22:18:55Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/147861 |
| url |
http://hdl.handle.net/10362/147861 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1664-3224 PURE: 50457721 https://doi.org/10.3389/fimmu.2022.1021768 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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mluisa.alvim@gmail.com |
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